Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Daniel J Jansen"'
Autor:
Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Externí odkaz:
https://doaj.org/article/b82bd2d7d5a04000a7a64e580355ce3f
Autor:
Qin Yan, Marcus W. Bosenberg, Daniel P. Kelly, Matthew D. Hall, Anton Simeonov, Stephen C. Kales, Daniel J. Jansen, Ling Lai, Irina Krykbaeva, Meaghan K. McGeary, Shang-Min Zhang, Xiaoni Liu
Tumor heterogeneity is a major challenge for cancer treatment, especially due to the presence of various subpopulations with stem cell or progenitor cell properties. In mouse melanomas, both CD34+p75− (CD34+) and CD34−p75− (CD34−) tumor subpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067c56d0d5b3eb34e6f9c5b1dfc605d1
https://doi.org/10.1158/1535-7163.c.6538539.v1
https://doi.org/10.1158/1535-7163.c.6538539.v1
Autor:
Qin Yan, Marcus W. Bosenberg, Daniel P. Kelly, Matthew D. Hall, Anton Simeonov, Stephen C. Kales, Daniel J. Jansen, Ling Lai, Irina Krykbaeva, Meaghan K. McGeary, Shang-Min Zhang, Xiaoni Liu
Figure S1. Responses of different YUMM cell lines to BRAFi treatment; Figure S2. Inhibition of KDM5 family members by shRNA knockdown and pan-KDM5 inhibitors; Figure S3. Subpopulation composition in tumors of different volumes; Figure S4. In vivo BRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29b44f79f8fe1852f77e511980e40fd
https://doi.org/10.1158/1535-7163.22506975
https://doi.org/10.1158/1535-7163.22506975
Autor:
Irina Krykbaeva, Shang-Min Zhang, Stephen C. Kales, Daniel J. Jansen, Meaghan K. McGeary, Matthew D. Hall, Ling Lai, Xiaoni Liu, Anton Simeonov, Qin Yan, Daniel P. Kelly, Marcus Bosenberg
Publikováno v:
Molecular Cancer Therapeutics. 18:706-717
Tumor heterogeneity is a major challenge for cancer treatment, especially due to the presence of various subpopulations with stem cell or progenitor cell properties. In mouse melanomas, both CD34+p75− (CD34+) and CD34−p75− (CD34−) tumor subpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad613cb2e202ff11c6758a11e30835d
https://doi.org/10.1158/1535-7163.mct-18-0395
https://doi.org/10.1158/1535-7163.mct-18-0395
Autor:
Daniel J. Crawford, Dorjbal Dorjsuren, Adam Yasgar, Amanda E. Rieffer, Anton Simeonov, Ganesha Rai, Daniel J. Jansen, Patricia J. Gearhart, Reuben S. Harris, Daniel J. Salamango, Robert W. Maul, Alexey V. Zakharov, Juan Alvarez-Gonzalez, Rahul M. Kohli, Juan J. Marugan
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Activation-induced deaminase (AID) not only mutates DNA within the immunoglobulin loci to generate antibody diversity, but it also promotes development of B cell lymphomas. To tame this mutagen, we performed a quantitative high-thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bc3dabb1d62a962a938d080f3431cf
https://pubmed.ncbi.nlm.nih.gov/34151211
https://pubmed.ncbi.nlm.nih.gov/34151211
Autor:
Paul M Will, Wenwei Huang, Stephan Meister, Dorjbal Dorjsuren, Anton Simeonov, Bryan T. Mott, Andrew T Girvin, Pranav Shah, David A. Fidock, Daniel C. Talley, Benjamin A Sigmon, Richard T. Eastman, Xin Xu, Sachel Mok, Leila S. Ross, Tomas Yeo, Daniel J. Jansen, Robert F. Campbell, Alexey V. Zakharov, Richard J. Sciotti, Carleen Klumpp-Thomas, Yevgeniya Antonova-Koch, Norman C. Waters, Juan J. Marugan, Norma Roncal, Elizabeth A. Winzeler, David J. Maloney, Kathryn J. Wicht, Ajit Jadhav, Hongmao Sun
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
The spread of Plasmodium falciparum parasites resistant to most first-line antimalarials creates an imperative to enrich the drug discovery pipeline, preferably with curative compounds that can also act prophylactically. We report a phenotypic quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ec2791ad529c747fa218cd7678c5fe
https://pubmed.ncbi.nlm.nih.gov/33483532
https://pubmed.ncbi.nlm.nih.gov/33483532
Autor:
Daniel J. Jansen, Ryan A. Shenvi, Matthew P. Mower, Norihiro Tada, Jeffrey C. Umotoy, Megan M. Blewett, Benjamin F. Cravatt, Dennis W. Wolan
Publikováno v:
ACS Central Science, Vol 2, Iss 6, Pp 401-408 (2016)
ACS Central Science
ACS Central Science
We describe a general method to synthesize the iminium tetrahydrothiophene embedded in the dimeric Nuphar alkaloids. In contrast to prior studies, the sulfur atom of the thiaspirane pharmacophore is shown to be electrophilic. This α-thioether reacts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7663b46d53a8e11975c05e9129714490
https://doi.org/10.1021/acscentsci.6b00113
https://doi.org/10.1021/acscentsci.6b00113
Autor:
Matthew D. Hall, Stephen C. Kales, John R. Shanks, Clayton B. Woodcock, Katherine Pohida, Ganesha Rai, Xin Xu, Xiaodong Cheng, Qin Chen, Bryan T. Mott, Xing Zhang, Daniel J. Jansen, David J. Maloney, Ajit Jadhav, Matthew G. Cyr, Xin Hu, Pranav Shah, John R. Horton, Xu Liu, Haian Fu, Paula M. Vertino, Mark J. Henderson, Anton Simeonov
The active sites of hundreds of human α-ketoglutarate (αKG) and Fe(II)-dependent dioxygenases are exceedingly well preserved, which challenges the design of selective inhibitors. We identified a noncatalytic cysteine (Cys481 in KDM5A) near the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a9df54129d98fb0b1a05fc30b2f7bc
https://europepmc.org/articles/PMC6467790/
https://europepmc.org/articles/PMC6467790/
Autor:
Ajit Jadhav, Lizhen Wu, Daniel J. Jansen, Xin Hu, Mark J. Henderson, David J. Maloney, John R. Horton, Jian Cao, Stephen C. Kales, Bryan T. Mott, Anton Simeonov, Qin Yan, Shu Zhu, Wesley L. Cai, Gerald S. Shadel, Zongzhi Liu, Jocelyn F. Chen, Meiling Zhang, Xiaodong Cheng, Katherine Pohida, Ganesha Rai, Akiko Iwasaki, Sabine Lang, Matthew D. Hall
Publikováno v:
PLoS Biology
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92ce627a76571c3862e1d1c95959892
https://pubmed.ncbi.nlm.nih.gov/30080846
https://pubmed.ncbi.nlm.nih.gov/30080846
Autor:
Bryan T. Mott, Ganesha Rai, Stephen C. Kales, Kai Zhang, Daniel J. Jansen, Yuhong Fang, Xu Liu, Paula M. Vertino, John R. Shanks, David J. Maloney, Lizhen Wu, Ajit Jadhav, Xiaodong Cheng, Haian Fu, Xing Zhang, Anton Simeonov, Matthew D. Hall, Qin Yan, Katherine Pohida, Xin Hu, John R. Horton, Mark J. Henderson
Publikováno v:
Journal of medicinal chemistry. 61(7)
Isomers of chiral drugs can exhibit marked differences in biological activities. We studied the binding and inhibitory activities of 12 compounds against KDM5A. Among them are two pairs of enantiomers representing two distinct inhibitor chemotypes, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c4323ae84de46e3635fd004f3bc3ac
https://pubmed.ncbi.nlm.nih.gov/29537847
https://pubmed.ncbi.nlm.nih.gov/29537847