Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Daniel J Horan"'
Autor:
Aina He, Songhai Tian, Oded Kopper, Daniel J Horan, Peng Chen, Roderick T Bronson, Ren Sheng, Hao Wu, Lufei Sui, Kun Zhou, Liang Tao, Quan Wu, Yujing Huang, Zan Shen, Sen Han, Xueqing Chen, Hong Chen, Xi He, Alexander G Robling, Rongsheng Jin, Hans Clevers, Dongxi Xiang, Zhe Li, Min Dong
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002353 (2023)
Wnt signaling pathways are transmitted via 10 homologous frizzled receptors (FZD1-10) in humans. Reagents broadly inhibiting Wnt signaling pathways reduce growth and metastasis of many tumors, but their therapeutic development has been hampered by th
Externí odkaz:
https://doaj.org/article/c1f3079f1d4342a0a3d6ba9ffe231f87
Autor:
Whitney A. Bullock, April M. Hoggatt, Daniel J. Horan, Andrew J. Elmendorf, Amy Y. Sato, Teresita Bellido, Gabriela G. Loots, Fredrick M. Pavalko, Alexander G. Robling
Publikováno v:
iScience, Vol 20, Iss , Pp 205-215 (2019)
Summary: Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4
Externí odkaz:
https://doaj.org/article/f7f843d78c6348eabf7967aba03f1a68
Autor:
Roy B. Choi, April M. Hoggatt, Daniel J. Horan, Emily Z. Rogers, Gabriela G. Loots, Alexander G. Robling
Publikováno v:
Journal of Bone and Mineral Research. 38:765-774
Autor:
Emily G. Atkinson, Michele Adaway, Daniel J. Horan, Crystal Korff, Angela Klunk, Ashley L. Orr, Katherine Ratz, Teresita Bellido, Lilian I. Plotkin, Alexander G. Robling, Joseph P. Bidwell
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchReferences.
Activation of bone anabolic pathways is a fruitful approach for treating severe osteoporosis, yet FDA-approved osteoanabolics, eg, parathyroid hormone (PTH), have limited efficacy. Improving their potency is a promising strategy for maximizing bone a
Autor:
null Emily G. Atkinson, null Michele Adaway, null Daniel J. Horan, null Crystal Korff, null Angela Klunk, null Ashley L. Orr, null Katherine Ratz, null Teresita Bellido, null Lilian I. Plotkin, null Alexander G. Robling, null Joseph P. Bidwell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a94a7f0e3f992ea78a7d72671c47245d
https://doi.org/10.1002/jbmr.4732/v2/response1
https://doi.org/10.1002/jbmr.4732/v2/response1
Autor:
Daenique H.A. Jengelley, Meijing Wang, Ashok Narasimhan, Joseph E. Rupert, Andrew R. Young, Xiaoling Zhong, Daniel J. Horan, Alexander G. Robling, Leonidas G. Koniaris, Teresa A. Zimmers
Publikováno v:
Cytokine. 159
Musculoskeletal diseases such as muscular dystrophy, cachexia, osteoarthritis, and rheumatoid arthritis impair overall physical health and reduce survival. Patients suffer from pain, dysfunction, and dysmobility due to inflammation and fibrosis in bo
Autor:
Caitlin, Resendes, Daniel J, Horan, Alexander G, Robling, Benlian, Gao, Ginger L, Milne, Matthew L, Warman
Publikováno v:
Bone. 158
Serotonin (5HT) is a chemical messenger with biologic activities affecting multiple organs. Within the skeletal system, studies in mice and humans suggest blood 5HT levels affect bone, with elevations impairing and reductions enhancing bone accrual.
Autor:
Whitney A. Bullock, Xi He, Alexander G. Robling, Xinjun Zhang, Jung Min Hong, Daniel J. Horan, Emily Z. Pemberton, Roy B Choi, April M. Hoggatt
Publikováno v:
J Bone Miner Res
Wnt signaling plays a vital role in the cell biology of skeletal patterning, differentiation, and maintenance. Notum is a secreted member of the α/β-hydrolase superfamily that hydrolyzes the palmitoleoylate modification on Wnt proteins, thereby dis
Autor:
Teresita Bellido, Alexander G. Robling, April M. Hoggatt, Andrew J. Elmendorf, Daniel J. Horan, Amy Y. Sato, Fredrick M. Pavalko, Gabriela G. Loots, Whitney A. Bullock
Publikováno v:
iScience
iScience, Vol 20, Iss, Pp 205-215 (2019)
iScience, Vol 20, Iss, Pp 205-215 (2019)
Summary Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4K
Autor:
Daniel J. Horan, April M. Hoggatt, Hiroki Yokota, Fredrick M. Pavalko, Alexander G. Robling, Whitney A. Bullock, Karl J. Lewis, Steven Hann, Matthew L. Warman, Gabriela G. Loots, Aimy Sebastian
Publikováno v:
J Bone Miner Res
Mechanical stimulation is a key regulator of bone mass, maintenance, and turnover. Wnt signaling is a key regulator of mechanotransduction in bone, but the role of β-catenin-an intracellular signaling node in the canonical Wnt pathway-in disuse mech