Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Daniel J Fazakerley"'
Autor:
Alison L Kearney, Dougall M Norris, Milad Ghomlaghi, Martin Kin Lok Wong, Sean J Humphrey, Luke Carroll, Guang Yang, Kristen C Cooke, Pengyi Yang, Thomas A Geddes, Sungyoung Shin, Daniel J Fazakerley, Lan K Nguyen, David E James, James G Burchfield
Publikováno v:
eLife, Vol 10 (2021)
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been
Externí odkaz:
https://doaj.org/article/95b5ee5592d94a12a25916f631425d1d
Autor:
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Publikováno v:
eLife, Vol 7 (2018)
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This defect was observed in a ra
Externí odkaz:
https://doaj.org/article/8a5796fc74b24c25b9c3c989e6b15e61
Autor:
Westa Domanova, James R Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J Fazakerley, Sean J Humphrey, David E James, Zdenka Kuncic
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185871 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0157763.].
Externí odkaz:
https://doaj.org/article/aa8235c3b17140e59f0245d0ee9013ed
Autor:
Jasmin Gaugel, Neele Haacke, Ratika Sehgal, Markus Jähnert, Wenke Jonas, Anne Hoffmann, Matthias Blüher, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Joycelyn Tan, Annette Schürmann, Daniel J. Fazakerley, Heike Vogel
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 102014- (2024)
Objective: Picalm (phosphatidylinositol-binding clathrin assembly protein), a ubiquitously expressed clathrin-adapter protein, is a well-known susceptibility gene for Alzheimer's disease, but its role in white adipose tissue (WAT) function has not ye
Externí odkaz:
https://doaj.org/article/e91ee5beb1f043a1b62ff3f522be0fb8
Autor:
Rachael Fletcher, Christopher Gribben, Xiuquan Ma, James G Burchfield, Kristen C Thomas, James R Krycer, David E James, Daniel J Fazakerley
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95598 (2014)
The Niemann-Pick disease, type C1 (NPC1) gene encodes a transmembrane protein involved in cholesterol efflux from the lysosome. SNPs within NPC1 have been associated with obesity and type 2 diabetes, and mice heterozygous or null for NPC1 are insulin
Externí odkaz:
https://doaj.org/article/bc28627d325f4b2eb2736832c82d3e5f
Autor:
Daniel J. Fazakerley, Julian van Gerwen, Kristen C. Cooke, Xiaowen Duan, Elise J. Needham, Alexis Díaz-Vegas, Søren Madsen, Dougall M. Norris, Amber S. Shun-Shion, James R. Krycer, James G. Burchfield, Pengyi Yang, Mark R. Wade, Joseph T. Brozinick, David E. James, Sean J. Humphrey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The failure of metabolic tissues to respond to insulin is an early marker of type 2 diabetes. Here, the authors show, using global phosphoproteomics, that insulin resistance is caused by a marked rewiring of both canonical and non-canonical insulin s
Externí odkaz:
https://doaj.org/article/1d1d85eedd7542a2a8117c06e8ff0883
Autor:
Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY. Kong, Jelske N. van der Veen, Andrian Yang, Joshua W.K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, René L. Jacobs, Roland Stocker
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102127- (2021)
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a rang
Externí odkaz:
https://doaj.org/article/e5e37048d10e4f0db080cc6d7d4696a3
Autor:
Daniel J. Fazakerley, James R. Krycer, Alison L. Kearney, Samantha L. Hocking, David E. James
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 10, Pp 1720-1732 (2019)
Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and cardiovascular disease. These disorders have dramatically increased in incidence with modern life, suggesting that excess nutrients and obesity are major c
Externí odkaz:
https://doaj.org/article/d7041b314fe84c94a2616c15b142c9df
Autor:
Dougall Norris, Pengyi Yang, Sung-Young Shin, Alison L. Kearney, Hani Jieun Kim, Thomas Geddes, Alistair M. Senior, Daniel J. Fazakerley, Lan K. Nguyen, David E. James, James G. Burchfield
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102118- (2021)
Summary: Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in insulin signaling. Akt activation alone accounted for ~2
Externí odkaz:
https://doaj.org/article/011f0f4f926048ed890f7a576d06d29b
Autor:
Lake-Ee Quek, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W. Locasale, Tomoyoshi Soga, David E. James, Shinya Kuroda
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101786- (2020)
Externí odkaz:
https://doaj.org/article/f9326031781b4a06a1113f66a90c237c