Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Daniel J Fazakerley"'
Autor:
Jasmin Gaugel, Neele Haacke, Ratika Sehgal, Markus Jähnert, Wenke Jonas, Anne Hoffmann, Matthias Blüher, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Joycelyn Tan, Annette Schürmann, Daniel J. Fazakerley, Heike Vogel
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 102014- (2024)
Objective: Picalm (phosphatidylinositol-binding clathrin assembly protein), a ubiquitously expressed clathrin-adapter protein, is a well-known susceptibility gene for Alzheimer's disease, but its role in white adipose tissue (WAT) function has not ye
Externí odkaz:
https://doaj.org/article/e91ee5beb1f043a1b62ff3f522be0fb8
Autor:
Daniel J. Fazakerley, Julian van Gerwen, Kristen C. Cooke, Xiaowen Duan, Elise J. Needham, Alexis Díaz-Vegas, Søren Madsen, Dougall M. Norris, Amber S. Shun-Shion, James R. Krycer, James G. Burchfield, Pengyi Yang, Mark R. Wade, Joseph T. Brozinick, David E. James, Sean J. Humphrey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The failure of metabolic tissues to respond to insulin is an early marker of type 2 diabetes. Here, the authors show, using global phosphoproteomics, that insulin resistance is caused by a marked rewiring of both canonical and non-canonical insulin s
Externí odkaz:
https://doaj.org/article/1d1d85eedd7542a2a8117c06e8ff0883
Autor:
Zhiduan Su, James G. Burchfield, Pengyi Yang, Sean J. Humphrey, Guang Yang, Deanne Francis, Sabina Yasmin, Sung-Young Shin, Dougall M. Norris, Alison L. Kearney, Miro A. Astore, Jonathan Scavuzzo, Kelsey H. Fisher-Wellman, Qiao-Ping Wang, Benjamin L. Parker, G. Gregory Neely, Fatemeh Vafaee, Joyce Chiu, Reichelle Yeo, Philip J. Hogg, Daniel J. Fazakerley, Lan K. Nguyen, Serdar Kuyucak, David E. James
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Crosstalk between protein oxidation and other post-translational modifications remains unexplored. Here, the authors map the phosphoproteome, cysteine redox proteome and total proteome of adipocytes under acute oxidative stress and reveal crosstalk b
Externí odkaz:
https://doaj.org/article/100de65dcd654d9fbe6eaea348b3c57b
Autor:
Weiyu Chen, Sergey Tumanov, Daniel J. Fazakerley, James Cantley, David E. James, Louise L. Dunn, Taqi Shaik, Cacang Suarna, Roland Stocker
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102152- (2021)
Background & aims: Plasma concentrations of bilirubin, a product of heme catabolism formed by biliverdin reductase A (BVRA), inversely associate with the risk of metabolic diseases including hepatic steatosis and diabetes mellitus in humans. Bilirubi
Externí odkaz:
https://doaj.org/article/41af8d9bb78949eebc861578f2f815f1
Autor:
Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY. Kong, Jelske N. van der Veen, Andrian Yang, Joshua W.K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, René L. Jacobs, Roland Stocker
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102127- (2021)
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a rang
Externí odkaz:
https://doaj.org/article/e5e37048d10e4f0db080cc6d7d4696a3
Autor:
Alison L Kearney, Dougall M Norris, Milad Ghomlaghi, Martin Kin Lok Wong, Sean J Humphrey, Luke Carroll, Guang Yang, Kristen C Cooke, Pengyi Yang, Thomas A Geddes, Sungyoung Shin, Daniel J Fazakerley, Lan K Nguyen, David E James, James G Burchfield
Publikováno v:
eLife, Vol 10 (2021)
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been
Externí odkaz:
https://doaj.org/article/95b5ee5592d94a12a25916f631425d1d
Autor:
Daniel J. Fazakerley, James R. Krycer, Alison L. Kearney, Samantha L. Hocking, David E. James
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 10, Pp 1720-1732 (2019)
Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and cardiovascular disease. These disorders have dramatically increased in incidence with modern life, suggesting that excess nutrients and obesity are major c
Externí odkaz:
https://doaj.org/article/d7041b314fe84c94a2616c15b142c9df
Autor:
Dougall Norris, Pengyi Yang, Sung-Young Shin, Alison L. Kearney, Hani Jieun Kim, Thomas Geddes, Alistair M. Senior, Daniel J. Fazakerley, Lan K. Nguyen, David E. James, James G. Burchfield
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102118- (2021)
Summary: Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in insulin signaling. Akt activation alone accounted for ~2
Externí odkaz:
https://doaj.org/article/011f0f4f926048ed890f7a576d06d29b
Autor:
Lake-Ee Quek, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W. Locasale, Tomoyoshi Soga, David E. James, Shinya Kuroda
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101786- (2020)
Externí odkaz:
https://doaj.org/article/f9326031781b4a06a1113f66a90c237c
Autor:
Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar, Kyle L. Hoehn
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical library screening approach to identify molecules that
Externí odkaz:
https://doaj.org/article/5e4c5baf666144d5a43fe60f14c4e6fb