Zobrazeno 1 - 10
of 460
pro vyhledávání: '"Daniel J Drucker"'
Autor:
Leticia Forny Germano, Jacqueline A. Koehler, Laurie L. Baggio, Fiona Cui, Chi Kin Wong, Nikolaj Rittig, Xiemin Cao, Dianne Matthews, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102019- (2024)
Objective: The development of glucagon-like peptide-1 receptor (GLP-1R) agonists for the treatment of type 2 diabetes and obesity has been accompanied by evidence for anti-inflammatory and cytoprotective actions in the heart, blood vessels, kidney, a
Externí odkaz:
https://doaj.org/article/251c6b672668429ebb6e64cd03609235
Autor:
Dominic Landgraf, Anthony H Tsang, Alexei Leliavski, Christiane E Koch, Johanna L Barclay, Daniel J Drucker, Henrik Oster
Publikováno v:
eLife, Vol 4 (2015)
Circadian clocks coordinate 24-hr rhythms of behavior and physiology. In mammals, a master clock residing in the suprachiasmatic nucleus (SCN) is reset by the light–dark cycle, while timed food intake is a potent synchronizer of peripheral clocks s
Externí odkaz:
https://doaj.org/article/fdcf378753f949d79922396731b5316c
Autor:
William Roell, Tamer Coskun, Teayoun Kim, Libbey O’Farrell, Jennifer A. Martin, Shelly Nason, Jasmin Hernandez-Alamillo, Saidharshana Dhantu, Daniel J. Drucker, Kyle W. Sloop, James P. Steele, Jorge Alsina-Fernandez, Kirk M. Habegger
Publikováno v:
Molecular Metabolism, Vol 91, Iss , Pp 102073- (2025)
Objective: Glucagon is a crucial regulator of glucose and lipid metabolism as well as whole-body energy balance. Thus, modulation of glucagon receptor (GCGR) activity in the context of single-molecule multi-receptor co-agonists has become an emerging
Externí odkaz:
https://doaj.org/article/a43fcb007fdf44d8b7126f4df420df06
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e96863 (2014)
Islet adaptations to pregnancy were explored in C57BL6/J mice lacking functional receptors for glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP). Pregnant wild type mice and GIPRKO mice exhibited marked increases in islet and b
Externí odkaz:
https://doaj.org/article/47054f6e169d495d8ef62ca8c7aed7e3
Autor:
Thi-Mai Anh Dao, Aurélie Waget, Pascale Klopp, Matteo Serino, Christelle Vachoux, Laurent Pechere, Daniel J Drucker, Serge Champion, Sylvain Barthélemy, Yves Barra, Rémy Burcelin, Eric Sérée
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20700 (2011)
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavailability to assess the mec
Externí odkaz:
https://doaj.org/article/8b96eb10e8834befa95800ee2058fc4c
Autor:
Thomas U. Greiner, Ara Koh, Eduard Peris, Mattias Bergentall, Malin E.V. Johansson, Gunnar C. Hansson, Daniel J. Drucker, Fredrik Bäckhed
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101924- (2024)
Objectives: Gut microbiota increases energy availability through fermentation of dietary fibers to short-chain fatty acids in conventionally raised mice. Energy deficiency in germ-free (GF) mice increases glucagon-like peptide-1 (GLP-1) levels, which
Externí odkaz:
https://doaj.org/article/263a379437f5472790b2cc60cb953f8c
Autor:
Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J. Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M. Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C. Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H. Tschöp, Paul T. Pfluger, Jonathan D. Douros, Timo D. Müller
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101915- (2024)
Objective: The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether GIP regulates body weight and glucose c
Externí odkaz:
https://doaj.org/article/4df457ac59ce49e8af09680efdd590e2
Autor:
Thao D.V. Le, Payam Fathi, Amanda B. Watters, Blair J. Ellis, Gai-Linn K. Besing, Nadejda Bozadjieva-Kramer, Misty B. Perez, Andrew I. Sullivan, Jesse P. Rose, Laurie L. Baggio, Jacqueline Koehler, Jennifer L. Brown, Michelle B. Bales, Kaitlyn G. Nwaba, Jonathan E. Campbell, Daniel J. Drucker, Matthew J. Potthoff, Randy J. Seeley, Julio E. Ayala
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101718- (2023)
Objective: Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RA) and fibroblast growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading us to investigate mechanisms engaged by the GLP-1RA liraglutide to increa
Externí odkaz:
https://doaj.org/article/d72c33cca2fa47dca8da218c427827be
Autor:
Maegan E. Chen, Setareh Malekian Naeini, Arjuna Srikrishnaraj, Daniel J. Drucker, Zivit Fesler, Patricia L. Brubaker
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1829-1842 (2022)
Background & Aims: Leucine-rich repeat-containing G-protein–coupled receptor-5 (Lgr5)+/olfactomedin-4 (Olfm4)+ intestinal stem cells (ISCs) in the crypt base are crucial for homeostatic maintenance of the epithelium. The gut hormone, glucagon-like
Externí odkaz:
https://doaj.org/article/7903d4f158514e2ca82d59830f968335
Autor:
Jacqueline L. Beaudry, Kiran D. Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Holly E. Bates, Jonathan E. Campbell, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 28, Iss , Pp 14-25 (2019)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid metabolism. Loss or attenuation of GIP receptor (GIPR) action leads to re
Externí odkaz:
https://doaj.org/article/74333548414145d59b6704366a4af522