Regulation of endothelial-specific transgene expression by the LacI repressor protein in vivo.

Autor: Susan K Morton, Daniel J Chaston, Brett K Baillie, Caryl E Hill, Klaus I Matthaei

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95980 (2014)

Genetically modified mice have played an important part in elucidating gene function in vivo. However, conclusions from transgenic studies may be compromised by complications arising from the site of transgene integration into the genome and, in indu

Externí odkaz: https://doaj.org/article/5de9012ae57841ffbbc45a6fe6cdb646

Polymorphism in Endothelial Connexin40 Enhances Sensitivity to Intraluminal Pressure and Increases Arterial Stiffness

Autor: Brett K. Baillie, Khaled Machaca, Caryl E. Hill, Anthony W. Ashton, Katherine A. Lau, T. Hilton Grayson, Bruce J. Nicholson, Raphael Jean Courjaret, Jillian M. Heisler, Klaus I. Matthaei, Daniel J. Chaston

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 33:962-970

Objective— To determine whether impairment of endothelial connexin40 (Cx40), an effect that can occur in hypertension and aging, contributes to the arterial dysfunction and stiffening in these conditions. Approach and Results— A new transgenic mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf22c644b297a1ad9daea306590692f
https://doi.org/10.1161/atvbaha.112.300957

Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles

Autor: Anthie Ellis, Caryl E. Hill, Daniel J. Chaston, Hee-Sup Shin, Pernille B. Lærkegaard Hansen, Lauren Howitt, Ivana Y. Kuo

Publikováno v: Howitt, L, Kuo, I Y, Ellis, A, Chaston, D J, Shin, H-S, Hansen, P B & Hill, C E 2013, ' Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles ', Advances in Cardiovascular Research, vol. 98, no. 3, pp. 449-457 . https://doi.org/10.1093/cvr/cvt043

Aims As cardiovascular disease is characterized by reduced nitric oxide bioavailability, our aim was to determine the impact of this change on the mechanism underlying vascular tone of pressurized arteries in vitro and in vivo . Methods and results W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba46c9d323dd19c2804f0e04576497d7
https://doi.org/10.1093/cvr/cvt043

Non-linear relationship between hyperpolarisation and relaxation enables long distance propagation of vasodilatation

Autor: Daniel J. Chaston, F. R. Edwards, Kenichi Goto, Stephanie E. Wölfle, Shaun L. Sandow, Caryl E. Hill

Publikováno v: The Journal of Physiology. 589:2607-2623

Blood flow is adjusted to tissue demand through rapidly ascending vasodilatations resulting from conduction of hyperpolarisation through vascular gap junctions. We investigated how these dilatations can spread without attenuation if mediated by an el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40e2d7aaa45eb1dbe4a07b35cb05db46
https://doi.org/10.1113/jphysiol.2010.202580

Reversible transgene expression in mice: now you see it, now you don’t (1121.1)

Autor: Brett K. Baillie, Susan K. Morton, Caryl E. Hill, Klaus I. Matthaei, Daniel J. Chaston

Publikováno v: The FASEB Journal. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a119d006f6ce8bb7968fa5f48de239fd
https://doi.org/10.1096/fasebj.28.1_supplement.1121.1