Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Daniel J Bolland"'
Autor:
Cameron S Osborne, Lyubomira Chakalova, Jennifer A Mitchell, Alice Horton, Andrew L Wood, Daniel J Bolland, Anne E Corcoran, Peter Fraser
Publikováno v:
PLoS Biology, Vol 5, Iss 8, p e192 (2007)
Transcription in mammalian nuclei is highly compartmentalized in RNA polymerase II-enriched nuclear foci known as transcription factories. Genes in cis and trans can share the same factory, suggesting that genes migrate to preassembled transcription
Externí odkaz:
https://doaj.org/article/70c4679520954fabb6c965ff8f31b515
Autor:
Olga Mielczarek, Carolyn H. Rogers, Yinxiu Zhan, Louise S. Matheson, Michael J.T. Stubbington, Stefan Schoenfelder, Daniel J. Bolland, Biola M. Javierre, Steven W. Wingett, Csilla Várnai, Anne Segonds-Pichon, Simon J. Conn, Felix Krueger, Simon Andrews, Peter Fraser, Luca Giorgetti, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113074- (2023)
Summary: To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (VH), diversity (DH), and joining (JH)
Externí odkaz:
https://doaj.org/article/125cbc8ecfba40ce99ab9245a423021d
Autor:
Hashem Koohy, Daniel J. Bolland, Louise S. Matheson, Stefan Schoenfelder, Claudia Stellato, Andrew Dimond, Csilla Várnai, Peter Chovanec, Tamara Chessa, Jeremy Denizot, Raquel Manzano Garcia, Steven W. Wingett, Paula Freire-Pritchett, Takashi Nagano, Phillip Hawkins, Len Stephens, Sarah Elderkin, Mikhail Spivakov, Peter Fraser, Anne E. Corcoran, Patrick D. Varga-Weisz
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-24 (2018)
Abstract Background Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression and chromatin f
Externí odkaz:
https://doaj.org/article/6176506a0b014dd1a2e2a5beb2a2e029
Autor:
Daniel J. Bolland, Hashem Koohy, Andrew L. Wood, Louise S. Matheson, Felix Krueger, Michael J.T. Stubbington, Amanda Baizan-Edge, Peter Chovanec, Bryony A. Stubbs, Kristina Tabbada, Simon R. Andrews, Mikhail Spivakov, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2475-2487 (2016)
Variable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant of antigen receptor diversity. Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene usage. We have developed VDJ
Externí odkaz:
https://doaj.org/article/2754b12283b14484b5441338b9c3ac7a
Autor:
Louise S. Matheson, Daniel J. Bolland, Peter Chovanec, Felix Krueger, Simon Andrews, Hashem Koohy, Anne E. Corcoran
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
V(D)J recombination is essential for the generation of diverse antigen receptor (AgR) repertoires. In B cells, immunoglobulin kappa (Igκ) light chain recombination follows immunoglobulin heavy chain (Igh) recombination. We recently developed the DNA
Externí odkaz:
https://doaj.org/article/308388b4b3d8483f8570a4664004ecad
Autor:
Amanda, Baizan-Edge, Bryony A, Stubbs, Michael J T, Stubbington, Daniel J, Bolland, Kristina, Tabbada, Simon, Andrews, Anne E, Corcoran
Publikováno v:
Cell Reports
Summary Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. The role of interleukin-7 receptor (IL-7R) signaling in Igh recombination has been difficul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c96df32c9acda207a41786517de07f0c
https://pubmed.ncbi.nlm.nih.gov/34260907
https://pubmed.ncbi.nlm.nih.gov/34260907
Autor:
Kristina Tabbada, Anne E. Corcoran, Daniel J. Bolland, Amanda Baizan-Edge, Simon Andrews, Bryony A. Stubbs, Michael J. T. Stubbington
Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. It has been proposed that interleukin-7 receptor (IL-7R) signalling is necessary for Igh recombinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d54b6d2aa913ae09ff39a2ef6b94fb2e
https://doi.org/10.1101/2020.09.24.298000
https://doi.org/10.1101/2020.09.24.298000
Autor:
Kristina Tabbada, Amanda Baizan-Edge, Simon Andrews, Daniel J. Bolland, Michael J. T. Stubbington, Anne E. Corcoran, Bryony A. Stubbs
Publikováno v:
SSRN Electronic Journal.
Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. It has been proposed that interleukin-7 receptor (IL-7R) signalling is necessary for Igh recombinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aaf56b490bb7034322c19377c0b1008
https://doi.org/10.2139/ssrn.3751673
https://doi.org/10.2139/ssrn.3751673
Autor:
Steven W. Wingett, Kassim Kamaka, Danika L. Hill, Martin S. Zand, Jiong Wang, Elizabeth F. Wallin, Catherine Mkindi, François Spertini, Wim Pierson, Régine Audran, Daniel J. Bolland, Said Jongo, Sophie Houard, Michelle A. Linterman, Anne E. Corcoran, Edward J. Carr, Claudia Daubenberger
Publikováno v:
The Journal of experimental medicine, vol. 216, no. 8, pp. 1857-1873
The Journal of Experimental Medicine
The Journal of Experimental Medicine
A rational strategy to achieve optimal vaccine responses is to potentiate Tfh cells and the germinal center response. This work shows the adjuvant GLA-SE enhances circulating Tfh cells and enduring antibody responses to a malaria vaccine in Tanzanian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02643e911e2eb9a88542a1b440cd038
https://serval.unil.ch/notice/serval:BIB_B9B6A1FE4844
https://serval.unil.ch/notice/serval:BIB_B9B6A1FE4844
Autor:
Simon Andrews, Andrew L. Wood, Amanda Baizan-Edge, Hashem Koohy, Felix Krueger, Daniel J. Bolland, Mikhail Spivakov, Kristina Tabbada, Louise S. Matheson, Peter Chovanec, Anne E. Corcoran, Bryony A. Stubbs, Michael J. T. Stubbington
Publikováno v:
Cell Reports
Cell Reports, Vol 15, Iss 11, Pp 2475-2487 (2016)
Cell Reports, Vol 15, Iss 11, Pp 2475-2487 (2016)
Summary Variable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant of antigen receptor diversity. Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene usage. We have develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bafc076a00f9ae1dd289efc37c33575
http://europepmc.org/articles/PMC4914699
http://europepmc.org/articles/PMC4914699