Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel J, Warner"'
Autor:
Chris De Savi, Glen Andrews, Anthony Ronald Cook, Rhona J. Cox, Peter Stewart Gilmour, Simon Young, Daniel J. Warner, Beth Parker, Dickinson Mark, Amy McDonough, Matthew Dearman, Louis C. Morrill, Rob Riley
Publikováno v:
Journal of Medicinal Chemistry. 57:4661-4676
Oral phosphodiesterase 4 (PDE4) inhibitors, such as cilomilast and roflumilast, have been shown to be efficacious against chronic obstructive pulmonary disease (COPD). However, these drugs have been hampered by mechanism-related side effects such as
Publikováno v:
Molecular Informatics. 31:365-368
Matched molecular pairs analysis (MMPA)1,2 is an inverse quantitative structure activity relationship (QSAR) technique that is rapidly gaining popularity in the retrospective analysis of large experimental datasets.3,4 While much of the recent focus
Publikováno v:
Journal of Medicinal Chemistry. 54:7739-7750
Autor:
David Donald, Lilian Alcaraz, Daniel J. Warner, Nicholas Kindon, Andrew Bailey, Michael J. Stocks, Garry Pairaudeau, Keith Bowers, Jill Theaker, Fraser Hunt, Helen Edwards
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7458-7461
The optimisation of a new series of high potency muscarinic M3 antagonists, derived from high throughput screening library hit is described.
Publikováno v:
Allergy and Asthma Proceedings. 28:654-658
It is commonly believed that young children are incapable of pollen sensitization; therefore, skin testing usually is not performed to these allergens. The purpose of this study was to identify the frequency of positive skin tests to outdoor allergen
Autor:
Daniel J. Warner, Simon E. V. Phillips, Charles A. Laughton, Richard J. Bingham, Elizabeth Barratt, Steve W. Homans
Publikováno v:
Journal of the American Chemical Society. 127:11827-11834
In the present study we examine the enthalpy of binding of 2-methoxy-3-isobutylpyrazine (IBMP) to the mouse major urinary protein (MUP), using a combination of isothermal titration calorimetry (ITC), NMR, X-ray crystallography, all-atom molecular dyn
Autor:
Hongming Chen, Clare L. Walker, Daniel J. Warner, Louis-David Cantin, Tobias Noeske, Simone H. Stahl, J. Gerry Kenna
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 40(12)
The human bile salt export pump (BSEP) is a membrane protein expressed on the canalicular plasma membrane domain of hepatocytes, which mediates active transport of unconjugated and conjugated bile salts from liver cells into bile. BSEP activity there
Publikováno v:
Journal of medicinal chemistry. 54(22)
Publikováno v:
Journal of Cheminformatics
Journal of Cheminformatics, Vol 3, Iss Suppl 1, p O9 (2011)
Journal of Cheminformatics, Vol 3, Iss Suppl 1, p O9 (2011)
An algorithm to automatically identify and extract matched molecular pairs from a collection of compounds has been developed, allowing the learning associated with each molecular transformation to be readily exploited in drug discovery projects. Here