Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Daniel J, Stephenson"'
Sphingolipid changes in mouse brain and plasma after mild traumatic brain injury at the acute phases
Autor:
Koushik Mondal, Nobel A. Del Mar, Ashlyn A. Gary, Richard C. Grambergs, Mohd Yousuf, Faiza Tahia, Benjamin Stephenson, Daniel J. Stephenson, Charles E. Chalfant, Anton Reiner, Nawajes Mandal
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Traumatic brain injury (TBI) causes neuroinflammation and can lead to long-term neurological dysfunction, even in cases of mild TBI (mTBI). Despite the substantial burden of this disease, the management of TBI is precluded by an i
Externí odkaz:
https://doaj.org/article/290c698cee0740f99527e89df6d05ffe
Autor:
Tayleur D. White, Abdulaziz Almutairi, Ying Gai-Tusing, Daniel J. Stephenson, Benjamin D. Stephenson, Charles E. Chalfant, Xiaoyong Lei, Brian Lu, Bruce D. Hammock, Teresa P. DiLorenzo, Sasanka Ramanadham
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionWe reported that Ca2+-independent phospholipase A2β (iPLA2β)–derived lipids (iDLs) contribute to type 1 diabetes (T1D) onset. As CD4+ and CD8+ T cells are critical in promoting β-cell death, we tested the hypothesis that iDL signalin
Externí odkaz:
https://doaj.org/article/588f970bbb8d45fbb26e60d608d19390
Autor:
Curtis B. Read, Anika N. Ali, Daniel J. Stephenson, H. Patrick Macknight, Kenneth D. Maus, Chelsea L. Cockburn, Minjung Kim, Xiujie Xie, Jason A. Carlyon, Charles E. Chalfant
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTMany intracellular pathogens structurally disrupt the Golgi apparatus as an evolutionarily conserved promicrobial strategy. Yet, the host factors and signaling processes involved are often poorly understood, particularly for Anaplasma phagocy
Externí odkaz:
https://doaj.org/article/10e5f04be2dd4e119229141c954aa4ba
Autor:
Daniel J. Stephenson, H. Patrick MacKnight, L. Alexis Hoeferlin, Sonya L. Washington, Chelsea Sawyers, Kellie J. Archer, Jerome F. Strauss, III, Scott W. Walsh, Charles E. Chalfant
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100377- (2023)
There are few early biomarkers to identify pregnancies at risk of preeclampsia (PE) and abnormal placental function. In this cross-sectional study, we utilized targeted ultra-performance liquid chromatography-ESI MS/MS and a linear regression model t
Externí odkaz:
https://doaj.org/article/522536cd3ef54007b913cd11e770819b
Autor:
Kenneth D. Maus, Daniel J. Stephenson, Anika N. Ali, Henry Patrick MacKnight, Huey-Jing Huang, Jordi Serrats, Minjung Kim, Robert F. Diegelmann, Charles E. Chalfant
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 4, Pp 100187- (2022)
The sphingolipid, ceramide-1-phosphate (C1P), has been shown to promote the inflammatory phase and inhibit the proliferation and remodeling stages of wound repair via direct interaction with group IVA cytosolic phospholipase A2, a regulator of eicosa
Externí odkaz:
https://doaj.org/article/5bae0385420d4f2a836b992afeabb825
Autor:
Alexander J. Nelson, Daniel J. Stephenson, Christopher L. Cardona, Xiaoyong Lei, Abdulaziz Almutairi, Tayleur D. White, Ying G. Tusing, Margaret A. Park, Suzanne E. Barbour, Charles E. Chalfant, Sasanka Ramanadham
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 2, Pp 143-158 (2020)
Phospholipases A2 (PLA2s) catalyze hydrolysis of the sn-2 substituent from glycerophospholipids to yield a free fatty acid (i.e., arachidonic acid), which can be metabolized to pro- or anti-inflammatory eicosanoids. Macrophages modulate inflammatory
Externí odkaz:
https://doaj.org/article/6547dd63283e4d0aa77cb2128df44b45
Autor:
Yoshinori Hirano, Yong-Guang Gao, Daniel J Stephenson, Ngoc T Vu, Lucy Malinina, Dhirendra K Simanshu, Charles E Chalfant, Dinshaw J Patel, Rhoderick E Brown
Publikováno v:
eLife, Vol 10 (2021)
Externí odkaz:
https://doaj.org/article/6d93990aebd145498301352bbe65ccb0
Autor:
Alexander J. Nelson, Daniel J. Stephenson, Robert N. Bone, Christopher L. Cardona, Margaret A. Park, Ying G. Tusing, Xiaoyong Lei, George Kokotos, Christina L. Graves, Clayton E. Mathews, Joanna Kramer, Martin J. Hessner, Charles E. Chalfant, Sasanka Ramanadham
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Type 1 diabetes (T1D) is a consequence of autoimmune β cell destruction, but the role of lipids in this process is unknown. We previously reported that activation of Ca2+-independent phospholipase A2β (iPLA2β) modulates polarization of macrophages
Externí odkaz:
https://doaj.org/article/acc96d8d77f847bb9d00e773a381249e
Autor:
Yoshinori Hirano, Yong-Guang Gao, Daniel J Stephenson, Ngoc T Vu, Lucy Malinina, Dhirendra K Simanshu, Charles E Chalfant, Dinshaw J Patel, Rhoderick E Brown
Publikováno v:
eLife, Vol 8 (2019)
Ca2+-stimulated translocation of cytosolic phospholipase A2α (cPLA2α) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis. Structural insights into the cPLA2α preference for phosphatidy
Externí odkaz:
https://doaj.org/article/af6a1b2fae9e4f1fa435261f48886fe1
Supplementary Figure from Ceramide Kinase Inhibition Drives Ferroptosis and Sensitivity to Cisplatin in Mutant KRAS Lung Cancer by Dysregulating VDAC-Mediated Mitochondria Function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d155aa149bc771196861345e8dbdb4
https://doi.org/10.1158/1541-7786.22528218.v1
https://doi.org/10.1158/1541-7786.22528218.v1
