Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Daniel J, Smit"'
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is frequently detected in late stages, which leads to limited therapeutic options and a dismal overall survival rate. To date, no robust method for the detection of early-stage PDAC that can be used fo
Externí odkaz:
https://doaj.org/article/b8847a40687f44c1b4bcf77ba0ffe9bd
Autor:
Daniel J. Smit, Konstantin Hoffer, Bettina Bettin, Malte Kriegs, Laure Cayrefourcq, Udo Schumacher, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker
Publikováno v:
Cancer Medicine, Vol 13, Iss 20, Pp n/a-n/a (2024)
ABSTRACT Background Research on circulating tumor cells (CTCs) offers the opportunity to better understand the initial steps of blood‐borne metastasis as main cause of cancer‐related deaths. Here, we have used the colon cancer CTC‐MCC‐41 and
Externí odkaz:
https://doaj.org/article/01c855f9ce71411bbeb5e216d4700d46
Autor:
Rebekka Geißert, Angela Lammert, Stefanie Wirth, Rabea Hönig, Dirk Lohfink, Monika Unger, Denis Pek, Konstantin Schlüter, Theresa Scheftschik, Daniel J. Smit, Manfred Jücker, Andre Menke, Klaudia Giehl
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in increased amounts of active Ras-GTP and subsequently a hyperactivation of effector proteins
Externí odkaz:
https://doaj.org/article/6ad39e31b6e94163a40b075a091f8050
Autor:
Marie-Therese Haider, Jennifer Zarrer, Nicole Ridlmaier, Rafael Preuer, Daniel J. Smit, Hiroaki Saito, Eric Hesse, Hanna Taipaleenmäki
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100541- (2024)
Externí odkaz:
https://doaj.org/article/05f96b54edf94764848a229e40ef0d59
Autor:
Joanna Kempska, Leticia Oliveira-Ferrer, Astrid Grottke, Minyue Qi, Malik Alawi, Felix Meyer, Kerstin Borgmann, Fabienne Hamester, Kathrin Eylmann, Maila Rossberg, Daniel J. Smit, Manfred Jücker, Elena Laakmann, Isabell Witzel, Barbara Schmalfeldt, Volkmar Müller, Karen Legler
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe PI3K/AKT pathway is activated in 43-70% of breast cancer (BC)-patients and promotes the metastatic potential of BC cells by increasing cell proliferation, invasion and radioresistance. Therefore, AKT1-inhibition in combination with ra
Externí odkaz:
https://doaj.org/article/7882ba2141484a4e949b72c38b608411
Autor:
Ling-Yu Tian, Daniel J. Smit, Nadezhda V. Popova, Stefan Horn, Lis Noelia Velasquez, Samuel Huber, Manfred Jücker
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2168 (2024)
Hepatocellular carcinoma (HCC), the main pathological type of liver cancer, is related to risk factors such as viral hepatitis, alcohol intake, and non-alcoholic fatty liver disease (NAFLD). The constitutive activation of the PI3K/AKT signaling pathw
Externí odkaz:
https://doaj.org/article/f8627d04ddcc4445a4b7408327d461a0
Autor:
Justus M. Grewe, Paul-Richard Knapstein, Antonia Donat, Shan Jiang, Daniel J. Smit, Weixin Xie, Johannes Keller
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-9 (2022)
Abstract Osteoporosis is a systemic bone disease that affects more than 200 million people worldwide and is caused by the disruption of the equilibrium between osteoclastic bone resorption and osteoblastic bone formation. Sphingosine-1-phosphate (S1P
Externí odkaz:
https://doaj.org/article/d3786b0f0fc74921b23a5584f647c5a2
Autor:
Friedrich Haag, Carsten Bokemeyer, Lars Bullinger, Franziska Brauneck, Brit Fischer, Marius Witt, Jana Muschhammer, Jennyfer Oelrich, Pedro Henrique da Costa Avelar, Sophia Tsoka, Elisa Seubert, Daniel J Smit, Christin Ackermann, Jasmin Wellbrock, Walter Fiedler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Leukemia-associated macrophages (LAMs) represent an important cell population within the tumor microenvironment, but little is known about the phenotype, function, and plasticity of these cells. The present study provides an extensive char
Externí odkaz:
https://doaj.org/article/2e7533273bea4d89a9f1519e8d362800
Autor:
Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller, Tobias M Gorges, Manfred Jücker, Jean‐Paul Thiery, Cathrin Brisken, Sabine Riethdorf, Catherine Alix‐Panabières, Klaus Pantel
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-22 (2020)
Abstract Functional studies giving insight into the biology of circulating tumor cells (CTCs) remain scarce due to the low frequency of CTCs and lack of appropriate models. Here, we describe the characterization of a novel CTC‐derived breast cancer
Externí odkaz:
https://doaj.org/article/6fcb45740e9c4955a376a11179160a9e
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2652 (2023)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains unclearly described in HCC. The dysregulation of the PI3K/AKT/mTOR signa
Externí odkaz:
https://doaj.org/article/bd3d6008c4734153966840ce7fb057f3