Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Daniel J, Sheward"'
Autor:
Marco Mandolesi, Hrishikesh Das, Liset de Vries, Yiqiu Yang, Changil Kim, Manojj Dhinakaran, Xaquin Castro Dopico, Julian Fischbach, Sungyong Kim, Mariia V. Guryleva, Monika Àdori, Mark Chernyshev, Aron Stålmarck, Leo Hanke, Gerald M. McInerney, Daniel J. Sheward, Martin Corcoran, B. Martin Hällberg, Ben Murrell, Gunilla B. Karlsson Hedestam
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The continued evolution of SARS-CoV-2 underscores the need to understand qualitative aspects of the humoral immune response elicited by spike immunization. Here, we combine monoclonal antibody (mAb) isolation with deep B cell receptor (BCR)
Externí odkaz:
https://doaj.org/article/dd5bb1c8958649a5ad5a309a8a4fa7ee
Autor:
Klara Lenart, Rodrigo Arcoverde Cerveira, Fredrika Hellgren, Sebastian Ols, Daniel J. Sheward, Changil Kim, Alberto Cagigi, Matthew Gagne, Brandon Davis, Daritza Germosen, Vicky Roy, Galit Alter, Hélène Letscher, Jérôme Van Wassenhove, Wesley Gros, Anne-Sophie Gallouët, Roger Le Grand, Harry Kleanthous, Mimi Guebre-Xabier, Ben Murrell, Nita Patel, Gregory Glenn, Gale Smith, Karin Loré
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract The immune responses to Novavax’s licensed NVX-CoV2373 nanoparticle Spike protein vaccine against SARS-CoV-2 remain incompletely understood. Here, we show in rhesus macaques that immunization with Matrix-MTM adjuvanted vaccines predominant
Externí odkaz:
https://doaj.org/article/c088a289c59c484090d22680d31eac78
Autor:
Mark Chernyshev, Mrunal Sakharkar, Ruth I. Connor, Haley L. Dugan, Daniel J. Sheward, C. G. Rappazzo, Aron Stålmarck, Mattias N. E. Forsell, Peter F. Wright, Martin Corcoran, Ben Murrell, Laura M. Walker, Gunilla B. Karlsson Hedestam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Vaccination of SARS-CoV-2 convalescent individuals generates broad and potent antibody responses. Here, we isolate 459 spike-specific monoclonal antibodies (mAbs) from two individuals who were infected with the index variant of SARS-CoV-2 an
Externí odkaz:
https://doaj.org/article/9dd4d91fffe54e7ea8233be911d4cbb4
Autor:
Jingdian Zhang, Camilla Koolmeister, Jinming Han, Roberta Filograna, Leo Hanke, Monika Àdori, Daniel J. Sheward, Sina Teifel, Shreekara Gopalakrishna, Qiuya Shao, Yong Liu, Keying Zhu, Robert A. Harris, Gerald McInerney, Ben Murrell, Mike Aoun, Liselotte Bäckdahl, Rikard Holmdahl, Marcin Pekalski, Anna Wedell, Martin Engvall, Anna Wredenberg, Gunilla B. Karlsson Hedestam, Xaquin Castro Dopico, Joanna Rorbach
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Pathogenic mutations in mitochondrial (mt) tRNA genes that compromise oxidative phosphorylation (OXPHOS) exhibit heteroplasmy and cause a range of multisyndromic conditions. Although mitochondrial disease patients are known to suffer from abnormal im
Externí odkaz:
https://doaj.org/article/06ca1318ae034d2c89248663f7d9045f
Autor:
Pradeepa Pushparaj, Andrea Nicoletto, Xaquin Castro Dopico, Daniel J. Sheward, Sungyong Kim, Simon Ekström, Ben Murrell, Martin Corcoran, Gunilla B. Karlsson Hedestam
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting spik
Externí odkaz:
https://doaj.org/article/e2a07f927a7947e584bcb85beca8d4d7
Autor:
Lydia Scharf, Hannes Axelsson, Aikaterini Emmanouilidi, Nimitha R. Mathew, Daniel J. Sheward, Susannah Leach, Pauline Isakson, Ilya V. Smirnov, Emelie Marklund, Nicolae Miron, Lars-Magnus Andersson, Magnus Gisslén, Ben Murrell, Anna Lundgren, Mats Bemark, Davide Angeletti
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Understanding persistence and evolution of B cell clones after COVID-19 infection and vaccination is crucial for predicting responses against emerging viral variants and optimizing vaccines. Here, we collected longitudinal samples from patients with
Externí odkaz:
https://doaj.org/article/3af8f63320a84aac8da92ced88e27ffa
Autor:
Dennis Christensen, Charlotta Polacek, Daniel J. Sheward, Leo Hanke, Gerald McInerney, Ben Murrell, Katrine Top Hartmann, Henrik Elvang Jensen, Julie Zimmermann, Gregers Jungersen, Kristin Engelhart Illigen, Louise Krag Isling, Carlota Fernandez-Antunez, Santseharay Ramirez, Jens Bukh, Gabriel Kristian Pedersen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
SARS-CoV-2 continues to pose a threat to human health as new variants emerge and thus a diverse vaccine pipeline is needed. We evaluated SARS-CoV-2 HexaPro spike protein formulated in Alhydrogel® (aluminium oxyhydroxide) in Syrian hamsters, using an
Externí odkaz:
https://doaj.org/article/12655cec9204492e97cfbf44f7b7e228
Autor:
Leo Hanke, Hrishikesh Das, Daniel J. Sheward, Laura Perez Vidakovics, Egon Urgard, Ainhoa Moliner-Morro, Changil Kim, Vivien Karl, Alec Pankow, Natalie L. Smith, Bartlomiej Porebski, Oscar Fernandez-Capetillo, Erdinc Sezgin, Gabriel K. Pedersen, Jonathan M. Coquet, B. Martin Hällberg, Ben Murrell, Gerald M. McInerney
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Here, the authors isolate and characterize a bispecific monomeric nanobody that induces dimerization of SARS-CoV-2 spike trimers, neutralizes variants of concerns as well as SARS-CoV, and inhibits SARS-CoV-2 infection in mice.
Externí odkaz:
https://doaj.org/article/f14234a7e3914ec1bbba1c457db3bda6
Autor:
Govind Gupta, Bejan Hamawandi, Daniel J. Sheward, Ben Murrell, Leo Hanke, Gerald McInerney, Magda Blosi, Anna L. Costa, Muhammet S. Toprak, Bengt Fadeel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Silver (Ag) is known to possess antimicrobial properties which is commonly attributed to soluble Ag ions. Here, we showed that Ag nanoparticles (NPs) potently inhibited SARS-CoV-2 infection using two different pseudovirus neutralization assays. We al
Externí odkaz:
https://doaj.org/article/34bdef8931f2467c8306a18b712c1714
Autor:
Inga Szurgot, Leo Hanke, Daniel J. Sheward, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney, Peter Liljeström
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The outbreak of the SARS-CoV-2 virus and its rapid spread into a global pandemic made the urgent development of scalable vaccines to prevent coronavirus disease (COVID-19) a global health and economic imperative. Here, we characterized and c
Externí odkaz:
https://doaj.org/article/d1386101c6744298abd8dec1619e0d2b