Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Daniel J, Rolfe"'
1
Akademický článek
Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
Autor: R. Sumanth Iyer, Sarah R. Needham, Ioannis Galdadas, Benjamin M. Davis, Selene K. Roberts, Rico C. H. Man, Laura C. Zanetti-Domingues, David T. Clarke, Gilbert O. Fruhwirth, Peter J. Parker, Daniel J. Rolfe, Francesco L. Gervasio, Marisa L. Martin-Fernandez
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently found to be mutated in non-small cell lung cancer. Oncogenic EGFR has been successfully targeted by tyrosine kinase inhibitors, but acquired drug resistance eventually overcomes the e
Externí odkaz: https://doaj.org/article/85aaaaecf9114b44adb21e316e7276e8
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2
Akademický článek
The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Autor: Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M. P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
To prevent ligand-independent dimerisation the epidermal growth factor receptor (EGFR) is autoinhibited by an extracellular dimer interaction. Here, the authors use several imaging technologies and simulations to provide structural insights on the in
Externí odkaz: https://doaj.org/article/d8f1227aa2394ee08a80e9812006d6b2
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3
Akademický článek
A global sampler of single particle tracking solutions for single molecule microscopy.
Autor: Michael Hirsch, Richard Wareham, Ji W Yoon, Daniel J Rolfe, Laura C Zanetti-Domingues, Michael P Hobson, Peter J Parker, Marisa L Martin-Fernandez, Sumeetpal S Singh
Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0221865 (2019)
The dependence on model-fitting to evaluate particle trajectories makes it difficult for single particle tracking (SPT) to resolve the heterogeneous molecular motions typical of cells. We present here a global spatiotemporal sampler for SPT solutions
Externí odkaz: https://doaj.org/article/954a80e8d52c435d894c61e32f26ef77
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4
Akademický článek
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
Autor: Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these form
Externí odkaz: https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e
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5
A small molecule inhibitor of HER3: a proof-of-concept study
Autor: David M. Smith, Gregory Weitsman, Michael Hirsch, Ambrosius P. Snijders, Svend Kjaer, Roger George, Peter J. Parker, Shahid Mehmood, Daniel J. Rolfe, Marisa L. Martin-Fernandez, Jeroen Claus, Tony Ng, Selene K. Roberts, Martina Fitzek, Laura C. Zanetti-Domingues, Audrey Colomba, Andrew Madin
Publikováno v: Biochemical Journal
Despite being catalytically defective, pseudokinases are typically essential players of cellular signalling, acting as allosteric regulators of their active counterparts. Deregulation of a growing number of pseudokinases has been linked to human dise
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7379b2f95fb20dcf6e78c913982571d
http://europepmc.org/articles/PMC7489893
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8
The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X
Autor: Verity, Jackson, Julia, Hermann, Christopher J, Tynan, Daniel J, Rolfe, Robin A, Corey, Anna L, Duncan, Maxime, Noriega, Amy, Chu, Antreas C, Kalli, E Yvonne, Jones, Mark S P, Sansom, Marisa L, Martin-Fernandez, Elena, Seiradake, Matthieu, Chavent
Publikováno v: Structure (London, England : 1993). 30(9)
Fibronectin Leucine-rich Repeat Transmembrane (FLRT 1-3) proteins are a family of broadly expressed single-spanning transmembrane receptors that play key roles in development. Their extracellular domains mediate homotypic cell-cell adhesion and heter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0aa356d2598a488dcb684e4a8216d69
https://pubmed.ncbi.nlm.nih.gov/35700726
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9
Akademický článek
Hydrophobic fluorescent probes introduce artifacts into single molecule tracking experiments due to non-specific binding.
Autor: Laura C Zanetti-Domingues, Christopher J Tynan, Daniel J Rolfe, David T Clarke, Marisa Martin-Fernandez
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74200 (2013)
Single-molecule techniques are powerful tools to investigate the structure and dynamics of macromolecular complexes; however, data quality can suffer because of weak specific signal, background noise and dye bleaching and blinking. It is less well-kn
Externí odkaz: https://doaj.org/article/c1f81b89c6b34aeea5a8e46f785bf081
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10
Akademický článek
Measuring EGFR separations on cells with ~10 nm resolution via fluorophore localization imaging with photobleaching.
Autor: Sarah R Needham, Michael Hirsch, Daniel J Rolfe, David T Clarke, Laura C Zanetti-Domingues, Richard Wareham, Marisa L Martin-Fernandez
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62331 (2013)
Detecting receptor dimerisation and other forms of clustering on the cell surface depends on methods capable of determining protein-protein separations with high resolution in the ~10-50 nm range. However, this distance range poses a significant chal
Externí odkaz: https://doaj.org/article/65659914eed14992aed31154ac648a36
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