Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Daniel J, Puleston"'
Autor:
Matteo Villa, David E. Sanin, Petya Apostolova, Mauro Corrado, Agnieszka M. Kabat, Carmine Cristinzio, Annamaria Regina, Gustavo E. Carrizo, Nisha Rana, Michal A. Stanczak, Francesc Baixauli, Katarzyna M. Grzes, Jovana Cupovic, Francesca Solagna, Alexandra Hackl, Anna-Maria Globig, Fabian Hässler, Daniel J. Puleston, Beth Kelly, Nina Cabezas-Wallscheid, Peter Hasselblatt, Bertram Bengsch, Robert Zeiser, Sagar, Joerg M. Buescher, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment and how this process shapes the establishment of the CD8+ T cell pool.
Externí odkaz:
https://doaj.org/article/94dc27161c6a48b2b42944d1f1be38af
Autor:
Dingxi Zhou, Mariana Borsa, Daniel J. Puleston, Susanne Zellner, Jesusa Capera, Sharon Sanderson, Martina Schifferer, Svenja S. Hester, Xin Ge, Roman Fischer, Luke Jostins, Christian Behrends, Ghada Alsaleh, Anna Katharina Simon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Autophagy is known to impact CD4+ T cell proliferation but the identity of autophagosomal components remain unclear. Here the authors leverage a transgenic mouse model to assess the autophagosomal compartment and identify interleukin-7 receptor-α as
Externí odkaz:
https://doaj.org/article/1ccb857c105547c5b33bd8c47532fb9e
Autor:
Stefanie Scherer, Susanne G. Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina v. Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christoph A. Mayer, Percy Knolle, Martin Klingenspor, Valeria Fumagalli, Matteo Iannacone, Martin Prlic, Thomas Korn, Erika L. Pearce, Thomas Höfer, Anna M. Schulz, Dietmar Zehn
Publikováno v:
Nature Immunology
Blocking pyrimidine de novo synthesis by inhibiting dihydroorotate dehydrogenase is used to treat autoimmunity and prevent expansion of rapidly dividing cell populations including activated T cells. Here we show memory T cell precursors are resistant
Autor:
Joy Edwards-Hicks, Petya Apostolova, Joerg M. Buescher, Hannes Maib, Michal A. Stanczak, Mauro Corrado, Ramon I. Klein Geltink, Maria Elena Maccari, Matteo Villa, Gustavo E. Carrizo, David E. Sanin, Francesc Baixauli, Beth Kelly, Jonathan D. Curtis, Fabian Haessler, Annette Patterson, Cameron S. Field, George Caputa, Ryan L. Kyle, Melanie Soballa, Minsun Cha, Harry Paul, Jacob Martin, Katarzyna M. Grzes, Lea Flachsmann, Michael Mitterer, Liang Zhao, Frances Winkler, David Ali Rafei-Shamsabadi, Frank Meiss, Bertram Bengsch, Robert Zeiser, Daniel J. Puleston, David O’Sullivan, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Immunology
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well understood. Here we show that, although naive T cells are rich in polyunsaturated phosphoinositides (PIPn with 3-4 double bonds), Teff cells have unique PIPn marked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bcbbf423f9a7b51630fb44cecc15a8
https://hdl.handle.net/21.11116/0000-000D-12D6-D21.11116/0000-000D-12D8-B
https://hdl.handle.net/21.11116/0000-000D-12D6-D21.11116/0000-000D-12D8-B
Autor:
Ya-Ting Wang, Alissa J. Trzeciak, Waleska Saitz Rojas, Pedro Saavedra, Yan-Ting Chen, Rachel Chirayil, Jon Iker Etchegaray, Christopher D. Lucas, Daniel J. Puleston, Kayvan R. Keshari, Justin S.A. Perry
Publikováno v:
Wang, Y-T, Trzeciak, A, Saitz Rojas, W, Saavedra, P, Chen, Y-T, Chirayil, R, Etchegaray, J I, Lucas, C D, Puleston, D, Keshari, K R & Perry, J S A 2022, ' Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments ', Cell Metabolism . https://doi.org/10.1016/j.cmet.2022.12.005
Apoptotic cell clearance (efferocytosis), a process essential for organismal homeostasis, is performed by phagocytes that inhabit harsh tissue environments, including physiologic hypoxia. Here, we find macrophages, the predominant tissue-resident pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c593d4d11765ae5621f0e8065f6d1fd
https://www.pure.ed.ac.uk/ws/files/319436586/Wang_Submission.pdf
https://www.pure.ed.ac.uk/ws/files/319436586/Wang_Submission.pdf
Autor:
Daniel J. Puleston
Publikováno v:
Nature. 616:257-258
Autor:
Francesc Baixauli, Klara Piletic, Daniel J. Puleston, Matteo Villa, Cameron S. Field, Lea J. Flachsmann, Andrea Quintana, Nisha Rana, Joy Edwards-Hicks, Mai Matsushita, Michal A. Stanczak, Katarzyna M. Grzes, Agnieszka M. Kabat, Mario Fabri, George Caputa, Beth Kelly, Mauro Corrado, Yaarub Musa, Katarzyna J. Duda, Gerhard Mittler, David O’Sullivan, Hiromi Sesaki, Thomas Jenuwein, Joerg M. Buescher, Edward J. Pearce, David E. Sanin, Erika L. Pearce
Publikováno v:
Nature
CD4+ T cell differentiation requires metabolic reprogramming to fulfil the bioenergetic demands of proliferation and effector function, and enforce specific transcriptional programmes1-3. Mitochondrial membrane dynamics sustains mitochondrial process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b176219f4d5bd0e37689d90bf3777d
https://europepmc.org/articles/PMC9844518/
https://europepmc.org/articles/PMC9844518/
Autor:
Ya-Ting Wang, Alissa Trzeciak, Waleska Saitz Rojas, Pedro Saavedra, Yan-Ting Chen, Rachel Chirayil, Jon Iker Etchegaray, Christopher D. Lucas, Daniel J. Puleston, Kayvan R. Keshari, Justin S. A. Perry
SummaryApoptotic cell clearance (efferocytosis), a process essential for organismal homeostasis, is performed by phagocytes that inhabit a wide range of environments, including physiologic hypoxia. Here, we find macrophages, the predominant tissue-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b3abe2ffec01f183d10e0d9ca53b00
https://doi.org/10.1101/2022.08.04.502838
https://doi.org/10.1101/2022.08.04.502838
Autor:
Kerry A. Pierce, Manoocher Soleimani, David DeTomaso, Lloyd Bod, Julian Avila-Pacheco, Elliot Akama-Garren, Brandon Schellhaass, Nir Yosef, Vasundhara Singh, Pratiksha I. Thakore, Allon Wagner, Sarah Zaghouani, Clary B. Clish, Raymond A. Sobel, James Kaminski, Alexandra Schnell, Erika L. Pearce, Chao Wang, Johannes Fessler, Daniel J. Puleston, Aviv Regev, Vijay K. Kuchroo, Elena Christian, Noga Ron-Harel, Vivian Paraskevi Douglas, Marcia C. Haigis
Publikováno v:
Cell
Cell, vol 184, iss 16
Cell, vol 184, iss 16
Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a516f7d904eb1d13dfbea99d5d9100ca
https://hdl.handle.net/21.11116/0000-000D-1A86-F21.11116/0000-000D-1A88-D
https://hdl.handle.net/21.11116/0000-000D-1A86-F21.11116/0000-000D-1A88-D
Autor:
Daniel J Puleston, Hanlin Zhang, Timothy J Powell, Elina Lipina, Stuart Sims, Isabel Panse, Alexander S Watson, Vincenzo Cerundolo, Alain RM Townsend, Paul Klenerman, Anna Katharina Simon
Publikováno v:
eLife, Vol 3 (2014)
During infection, CD8+ T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that CD8+ T cell memory formation becomes defective in old age, the cellular mechanism is largely
Externí odkaz:
https://doaj.org/article/ce12fecbf3f241cfaec733408cc19eea