TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma.

Autor: Daniel J Mullen, Chunli Yan, Diane S Kang, Beiyun Zhou, Zea Borok, Crystal N Marconett, Peggy J Farnham, Ite A Offringa, Suhn Kyong Rhie

Publikováno v: PLoS Genetics, Vol 16, Iss 9, p e1009023 (2020)

Lung cancer is the leading cause of cancer-related death and lung adenocarcinoma is its most common subtype. Although genetic alterations have been identified as drivers in subsets of lung adenocarcinoma, they do not fully explain tumor development.

Externí odkaz: https://doaj.org/article/692a71ce835c4814b88eb6d01cb57628

Figure S6 from LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response

Autor: Crystal N. Marconett, Zea Borok, Beiyun Zhou, Sean K. Lynch, Amrita Bhat, Riya Goel, Autumn Saizan, Michele Ramos Correa, Alexander Alvarado, Daniel J. Mullen, Gopika Nandagopal, Zhengmin Cong, Jonathan Castillo, Vishaly Kumaran, Shandy Shahabi

Figure S6. TCGA LUAD methylation at the LINC00261 locus. A. Individual CpGs are denoted by their Illumina 450K designation. Scale = 0 (no methylation) to 1 (complete methylation). Hg19-based coordinates for each probe are listed below the cg ascensio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f74c1e04365ab6e86923cc40c9da42e
https://doi.org/10.1158/0008-5472.22420773.v1

Supplemental Tables 1,2,3 from LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response

Autor: Crystal N. Marconett, Zea Borok, Beiyun Zhou, Sean K. Lynch, Amrita Bhat, Riya Goel, Autumn Saizan, Michele Ramos Correa, Alexander Alvarado, Daniel J. Mullen, Gopika Nandagopal, Zhengmin Cong, Jonathan Castillo, Vishaly Kumaran, Shandy Shahabi

Supplemental Table T1. List of Primers for LINC00261 detection and cloning. Supplemental Table T2. Differentially expressed lncRNAs in LUAD versus primary AEC. Supplemental Table T3. Differentially expressed genes in H522-CMV-LINC00261 vs CMV-NEO con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928a8d091c67f15df0d703ff4da236c8
https://doi.org/10.1158/0008-5472.22420767

Alveolar epithelial type 1 cells serve as a cell of origin for lung adenocarcinoma with distinct molecular and phenotypic presentation

Autor: Minxiao Yang, Hua Shen, Per Flodby, Michael D. Koss, Rania Bassiouni, Yixin Liu, Tea Jashashvili, Theresa R. Stueve, Daniel J. Mullen, Amy L. Ryan, John Carpten, Alessandra Castaldi, W. Dean Wallace, Beiyun Zhou, Zea Borok, Crystal N. Marconett

Lung adenocarcinoma (LUAD) is the most common subtype of cancer arising in the distal lung. LUAD encompasses several pathologic subtypes, each with differing clinical outcomes and biological behaviors. However, the molecular and cellular underpinning

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00cfefb98b35cc7a417ba940fcdb1eb0
https://doi.org/10.1101/2022.10.29.514334

The Sulfotransferase SULT1C2 is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and is Associated with Patient Outcome in Lung Adenocarcinoma

Autor: Ite A. Offringa, Mihaela Campan, Candace Johnson, Daniel J. Mullen, Suhaida A. Selamat, Crystal N. Marconett

Publikováno v: International Journal of Environmental Research and Public Health, Vol 19, Iss 416, p 416 (2022)
International Journal of Environmental Research and Public Health; Volume 19; Issue 1; Pages: 416

Lung cancer is the leading cause of cancer-related death. Tobacco exposure is associated with 80–90% of lung cancer cases. The SULT1C2 sulfotransferase modifies xenobiotic compounds to enhance secretion but can also render these compounds carcinoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458dff3d30c5eac3d2b4be44a9a1c5b1
https://doi.org/10.21203/rs.3.rs-795539/v1