Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Daniel J, Minion"'
Autor:
Nathan T, Ihle, Ryan, Williams, Sherry, Chow, Wade, Chew, Margareta I, Berggren, Gillian, Paine-Murrieta, Daniel J, Minion, Robert J, Halter, Peter, Wipf, Robert, Abraham, Lynn, Kirkpatrick, Garth, Powis
Publikováno v:
Molecular Cancer Therapeutics. 3:763-772
We have developed biologically stable semisynthetic viridins as inhibitors of phosphoinositide (PtdIns)-3-kinases. The most active compound was PX-866 (acetic acid (1S,4E,10R,11R,13S,14R)-[4-diallylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0644e177d8a9bb9db0b7d91e09e893f0
https://doi.org/10.1158/1535-7163.763.3.7
https://doi.org/10.1158/1535-7163.763.3.7
Autor:
Garth Powis, Gary G. Chiang, Peter Wipf, Daniel J. Minion, Lynn Kirkpatrick, Margareta Berggren, Robert T. Abraham, Caroline B. Ho, Robert J. Halter
Publikováno v:
Organic & Biomolecular Chemistry. 2:1911
A series of viridin analogs was prepared from wortmannin by nucleophilic ring opening at C(20) and evaluated against the signaling kinases PI-3-kinase and mTOR. Several subnanomolar enzyme inhibitors with orders of magnitude selectivity for PI-3-kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e719b8d76d05ba2fa0cb68666339473b
https://doi.org/10.1039/b405431h
https://doi.org/10.1039/b405431h