Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Daniel J, McGrail"'
Autor:
Mei Zhao, Tianxiao Wang, Frederico O. Gleber-Netto, Zhen Chen, Daniel J. McGrail, Javier A. Gomez, Wutong Ju, Mayur A. Gadhikar, Wencai Ma, Li Shen, Qi Wang, Ximing Tang, Sen Pathak, Maria Gabriela Raso, Jared K. Burks, Shiaw-Yih Lin, Jing Wang, Asha S. Multani, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Inactivating TP53 mutations leads to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promotes tumor development and progression. The GOF activities of TP53 mutati
Externí odkaz:
https://doaj.org/article/439599fe4b0841cea0b2d92022192f6d
Autor:
Jiakai Hou, Yanjun Wei, Jing Zou, Roshni Jaffery, Long Sun, Shaoheng Liang, Ningbo Zheng, Ashley M. Guerrero, Nicholas A. Egan, Ritu Bohat, Si Chen, Caishang Zheng, Xiaobo Mao, S. Stephen Yi, Ken Chen, Daniel J. McGrail, Nidhi Sahni, Pei-Yong Shi, Yiwen Chen, Xuping Xie, Weiyi Peng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CR
Externí odkaz:
https://doaj.org/article/40cc73e86a42414c8dbcd229f50f5fe6
Autor:
Swarnendu Tripathi, Hazheen K. Shirnekhi, Scott D. Gorman, Bappaditya Chandra, David W. Baggett, Cheon-Gil Park, Ramiz Somjee, Benjamin Lang, Seyed Mohammad Hadi Hosseini, Brittany J. Pioso, Yongsheng Li, Ilaria Iacobucci, Qingsong Gao, Michael N. Edmonson, Stephen V. Rice, Xin Zhou, John Bollinger, Diana M. Mitrea, Michael R. White, Daniel J. McGrail, Daniel F. Jarosz, S. Stephen Yi, M. Madan Babu, Charles G. Mullighan, Jinghui Zhang, Nidhi Sahni, Richard W. Kriwacki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular c
Externí odkaz:
https://doaj.org/article/8f35cd376f7a48a1b2f93578aa021be6
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, ICB alone has demonstrated only benefit in a small subset of patients with breast cancer. Recent studies have shown that agents targeting DNA damage response im
Externí odkaz:
https://doaj.org/article/be2b5cd1dc7440f9bbb2a9d0b36d9eb7
Autor:
Nathaniel Deboever, Nicolas Zhou, Daniel J. McGrail, Katarzyna Tomczak, Jacqueline L. Oliva, Hope A. Feldman, Edwin Parra, Jianjun Zhang, Percy P. Lee, Mara B. Antonoff, Wayne L. Hofstetter, Reza J. Mehran, Ravi Rajaram, David C. Rice, Jack A. Roth, Stephen S. Swisher, Ara A. Vaporciyan, Mehmet Altan, Annikka Weissferdt, Anne S. Tsao, Cara L. Haymaker, Boris Sepesi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundMalignant pleural mesothelioma (MPM) is associated with poor prognosis despite advances in multimodal therapeutic strategies. While patients with resectable disease may benefit from added survival with oncologic resection, patient selection
Externí odkaz:
https://doaj.org/article/31d96bb81be04ff5b9ce89f4dbae9747
Autor:
Víctor A. Arrieta, Crismita Dmello, Daniel J. McGrail, Daniel J. Brat, Catalina Lee-Chang, Amy B. Heimberger, Dhan Chand, Roger Stupp, Adam M. Sonabend
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing great interest in the neuro-oncology community. While several reports show that subsets of patients with glioma exhibit durable responses to immunotherapy, the effica
Externí odkaz:
https://doaj.org/article/e5116efe28b640fab150259dd932a2e9
Autor:
Hui Dai, Myrna Godoy, Diana Bell, Shiaw-Yih Lin, Daniel J McGrail, Luana Guimaraes de Sousa, Kaiyi Li, Mario L Marques-Piubelli, Cipriano Gonzalez, Sammy Ferri-Borgogno, Jared Burks
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Vaccination against COVID-19 is critical for immuno-compromised individuals, including patients with cancer. Systemic reactogenicity, a manifestation of the innate immune response to vaccines, occurs in up to 69% of patients following vaccination wit
Externí odkaz:
https://doaj.org/article/20a944e1411645f5a0c30f3c4c87870d
Autor:
Xian-De Liu, Wen Kong, Christine B. Peterson, Daniel J. McGrail, Anh Hoang, Xuesong Zhang, Truong Lam, Patrick G. Pilie, Haifeng Zhu, Kathryn E. Beckermann, Scott M. Haake, Sevinj Isgandrova, Margarita Martinez-Moczygemba, Nidhi Sahni, Nizar M. Tannir, Shiaw-Yih Lin, W. Kimryn Rathmell, Eric Jonasch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
PBRM1, encoding for a subunit of the SWI/SNF complex, is the second most frequently mutated gene in clear cell renal cell carcinoma (ccRCC). Here, the authors show that PBRM1 loss reduces IFNγ-mediated signalling resulting in a less immunogenic tumo
Externí odkaz:
https://doaj.org/article/2c2ffa7605cd4f008c5d3c780840e07f
Autor:
Anirban Maitra, Alexandre Reuben, Chantale Bernatchez, Marie-Andree Forget, Donastas Sakellariou-Thompson, Tina Cascone, Annikka Weissferdt, Jianjun Zhang, Boris Sepesi, Ignacio Wistuba, Ara A Vaporciyan, Marcelo V Negrao, Lorenzo Federico, John V Heymach, Don L Gibbons, Cara L Haymaker, Junya Fujimoto, Jack A Roth, Parin Shah, Peixin Jiang, Roohussaba Khairullah, Yan Long, Shiaw-Yih Lin, Meredith L Frank, Chantal Alexia Neutzler, Chi-Wan B Chow, Kyle Gregory Mitchell, Daniel J McGrail
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Background Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TIL) yielded clinical benefit in patients with checkpoint blockade immunotherapy-refractory non-small cell lung cancer (NSCLC) prompting a renewed interest in TIL-ACT. This pr
Externí odkaz:
https://doaj.org/article/695b65690403434c9d38fde087d200d1
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236619 (2020)
The outbreak the SARS-CoV-2 (CoV-2) virus has resulted in over 6.5 million cases of COVID19, greatly stressing global healthcare infrastructure. Lacking medical prophylactic measures to combat disease spread, many nations have adopted social distanci
Externí odkaz:
https://doaj.org/article/9f1a85c614324754ad95d1420cc3ebfb