Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Daniel J, Blackwell"'
Autor:
Ayesha Muhammad, Maria E. Calandranis, Bian Li, Tao Yang, Daniel J. Blackwell, M. Lorena Harvey, Jeremy E. Smith, Zerubabell A. Daniel, Ashli E. Chew, John A. Capra, Kenneth A. Matreyek, Douglas M. Fowler, Dan M. Roden, Andrew M. Glazer
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background KCNE1 encodes a 129-residue cardiac potassium channel (I Ks) subunit. KCNE1 variants are associated with long QT syndrome and atrial fibrillation. However, most variants have insufficient evidence of clinical consequences and thus
Externí odkaz:
https://doaj.org/article/b05f643c1f884a7dbcf19bfac871b67b
Autor:
Daniel J. Blackwell, Michela Faggioni, Matthew J. Wleklinski, Nieves Gomez-Hurtado, Raghav Venkataraman, Chelsea E. Gibbs, Franz J. Baudenbacher, Shiaoching Gong, Glenn I. Fishman, Patrick M. Boyle, Karl Pfeifer, Bjorn C. Knollmann
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs). What remains u
Externí odkaz:
https://doaj.org/article/2aa7c799ff5c4e1e88cbf5f6f46506a5
Autor:
Kyungsoo Kim, Daniel J. Blackwell, Samantha L. Yuen, Madelaine P. Thorpe, Jeffrey N. Johnston, Razvan L. Cornea, Björn C. Knollmann
Publikováno v:
Journal of Molecular and Cellular Cardiology. 180:1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bec21a9660c7f33d374b8f364ce40d6
https://doi.org/10.1016/j.yjmcc.2023.04.005
https://doi.org/10.1016/j.yjmcc.2023.04.005
Autor:
Andrew E Radbill, Lucy Y Lei, Sachin Y Paranjape, Daniel J Blackwell, Robert L Abraham, Derek S Chew, Satish R Raj, Björn C Knollmann
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246768 (2021)
AimsArrhythmia mechanisms in hypertrophic cardiomyopathy remain uncertain. Preclinical models suggest hypertrophic cardiomyopathy-linked mutations perturb sarcomere length-dependent activation, alter cardiac repolarization in rate-dependent fashion a
Externí odkaz:
https://doaj.org/article/fcae61050cae4e56b6221862325d1ff6
In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Moleculeent-Verticilide
Autor:
Daniel J. Blackwell, Abigail N. Smith, Tri Do, Aaron Gochman, Jeffrey Schmeckpeper, Corey R. Hopkins, Wendell S. Akers, Jeffrey N. Johnston, Bjorn C. Knollmann
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 385:205-213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::073231b528eb2db647e4ec425d76b31d
https://doi.org/10.1124/jpet.122.001455
https://doi.org/10.1124/jpet.122.001455
Autor:
Abigail N. Smith, Madelaine P. Thorpe, Daniel J. Blackwell, Suzanne M. Batiste, Corey R. Hopkins, Nathan D. Schley, Bjorn C. Knollmann, Jeffrey N. Johnston
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1755-1762
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc3e144be299f5130f430d9bee85ab0
https://doi.org/10.1021/acsmedchemlett.2c00377
https://doi.org/10.1021/acsmedchemlett.2c00377
Autor:
Matthew J. Wleklinski, Dmytro O. Kryshtal, Kyungsoo Kim, Shan S. Parikh, Daniel J. Blackwell, Isabelle Marty, V. Ramesh Iyer, Bjӧrn C. Knollmann
Publikováno v:
Circulation Research. 131:673-686
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal cardiac arrhythmia syndrome triggered by catecholamines released during exercise, stress, or sudden emotion. Variants in the calsequestrin-2 gene ( CASQ2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff6335ae7d7adb6b06ba79d29c80146
https://doi.org/10.1161/circresaha.121.320661
https://doi.org/10.1161/circresaha.121.320661
Autor:
Ayesha Muhammad, Maria E. Calandranis, Bian Li, Tao Yang, Daniel J. Blackwell, M. Lorena Harvey, Jeremy E. Smith, Ashli E. Chew, John A. Capra, Kenneth A. Matreyek, Douglas M. Fowler, Dan M. Roden, Andrew M. Glazer
Publikováno v:
bioRxiv
BackgroundKCNE1encodes a 129-residue cardiac potassium channel (IKs) subunit. KCNE1 variants are associated with long QT syndrome and atrial fibrillation. However, most variants have insufficient evidence of clinical consequences and thus limited cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9295df36fc7c8321c5c4fd825255bb6
https://europepmc.org/articles/PMC10168370/
https://europepmc.org/articles/PMC10168370/
Autor:
Christian L. Egly, Daniel J. Blackwell, Jeffrey Schmeckpeper, Brian P. Delisle, C. David Weaver, Björn C. Knollmann
Publikováno v:
Molecular Pharmacology. 101:236-245
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf9e23903a36fe06814798849fd0ccad
https://doi.org/10.1124/molpharm.121.000421
https://doi.org/10.1124/molpharm.121.000421
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hit-to-lead studies employ a variety of strategies to optimize binding to a target of interest. When a structure for the target is available, hypothesis-driven structure–activity relationships (SAR) are a powerful strategy for ref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef9b48506c315196dae7923c48e529c
https://doi.org/10.1021/acsmedchemlett.1c00508
https://doi.org/10.1021/acsmedchemlett.1c00508