Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction

Autor: Emilie Bequignon, David Mangin, Justine Bécaud, Jennifer Pasquier, Christelle Angely, Mathieu Bottier, Estelle Escudier, Daniel Isabey, Marcel Filoche, Bruno Louis, Jean-François Papon, André Coste

Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)

Abstract Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by an alteration in airway epithelial cell functions including barrier function, wound repair mechanisms, mucociliary clearance. The mechanisms leading to epitheli

Externí odkaz: https://doaj.org/article/dea3293154d24e3b96852151c878cc7f

Surfactant delivery in rat lungs: Comparing 3D geometrical simulation model with experimental instillation.

Autor: Alireza Kazemi, Bruno Louis, Daniel Isabey, Gary F Nieman, Louis A Gatto, Joshua Satalin, Sarah Baker, James B Grotberg, Marcel Filoche

Publikováno v: PLoS Computational Biology, Vol 15, Iss 10, p e1007408 (2019)

Surfactant Replacement Therapy (SRT), which involves instillation of a liquid-surfactant mixture directly into the lung airway tree, is a major therapeutic treatment in neonatal patients with respiratory distress syndrome (RDS). This procedure has pr

Externí odkaz: https://doaj.org/article/b4664508c6b148df982a90a9633dd5ee

A new index for characterizing micro-bead motion in a flow induced by ciliary beating: Part II, modeling.

Autor: Mathieu Bottier, Marta Peña Fernández, Gabriel Pelle, Daniel Isabey, Bruno Louis, James B Grotberg, Marcel Filoche

Publikováno v: PLoS Computational Biology, Vol 13, Iss 7, p e1005552 (2017)

Mucociliary clearance is one of the major lines of defense of the human respiratory system. The mucus layer coating the airways is constantly moved along and out of the lung by the activity of motile cilia, expelling at the same time particles trappe

Externí odkaz: https://doaj.org/article/0daeb2028b6e43f5a292347b6a976532

Nasal compliance measurement for diagnosis of idiopathic non-allergic rhinitis: A prospective case-controlled study of 63 patients

Autor: Christian Larger, J.-F. Papon, André Coste, Daniel Isabey, Bruno Louis, M. Devars du Mayne, Françoise Zerah-Lancner, E. Bequignon

Publikováno v: Clinical Otolaryngology. 43:328-332

• Idiopathic non allergic rhinitis (i-NAR) is a frequent cause of non-allergic rhinitis and associates nonspecific symptoms. There is no simple direct procedure to establish i-NAR diagnosis. • Diagnosis of i-NAR is currently based on an absence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed236984e59ebd9882c6085cf4a69e3
https://doi.org/10.1111/coa.12935

FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?

Autor: Estelle Escudier, Bruno Louis, André Coste, Daniel Isabey, Lucie Thomas, Christelle Angely, Mathieu Bottier, Jean-François Papon, Christine Dhommée, Emilie Bequignon, Valérie Gouilleux-Gruart

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2019, 20 (6), pp.1379. ⟨10.3390/ijms20061379⟩
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1379 (2019)
International Journal of Molecular Sciences, 2019, 20 (6), pp.1379. ⟨10.3390/ijms20061379⟩
Volume 20
Issue 6

Monoclonal antibodies (mAbs) are promising therapies to treat airway chronic inflammatory disease (asthma or nasal polyps). To date, no study has specifically assessed, in vitro, the potential function of neonatal Fc receptor (FcRn) in IgG transcytos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78f3a375de54f05eb682798e747cc88
https://hal.sorbonne-universite.fr/hal-02122366