Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniel I Sullivan"'
Autor:
Rohit Aggarwal, Chester V. Oddis, Daniel I. Sullivan, Siamak Moghadam-Kia, Didem Saygin, Daniel J. Kass, Diane C. Koontz, Peide Li, Craig S. Conoscenti, Amy L. Olson, on behalf of the MINT investigators
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background The Myositis Interstitial Lung Disease Nintedanib Trial (MINT) is a hybrid trial, which is enrolling patients both at local sites and remotely via a decentralised site. The trial will investigate the efficacy and safety of ninteda
Externí odkaz:
https://doaj.org/article/dfc7bd4701534e8db469db607fa23e05
Autor:
Angela M. Hinchie, Samantha L. Sanford, Kelly E. Loughridge, Rachel M. Sutton, Anishka H. Parikh, Agustin A. Gil Silva, Daniel I. Sullivan, Pattra Chun-On, Matthew R. Morrell, John F. McDyer, Patricia L. Opresko, Jonathan K. Alder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The telomere sequence, TTAGGG, is conserved across all vertebrates and plays an essential role in suppressing the DNA damage response by binding a set of proteins termed shelterin. Changes in the telomere sequence impair shelterin binding, i
Externí odkaz:
https://doaj.org/article/1d8229a837ff47dab3abeb379196b575
Autor:
Daniel I. Sullivan, Mao Jiang, Angela M. Hinchie, Mark G. Roth, Harinath Bahudhanapati, Mehdi Nouraie, Jie Liu, John F. McDyer, Rama K. Mallampalli, Yingze Zhang, Daniel J. Kass, Toren Finkel, Jonathan K. Alder
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Cellular senescence due to telomere dysfunction has been hypothesized to play a role in age-associated diseases including idiopathic pulmonary fibrosis (IPF). It has been postulated that paracrine mediators originating from senescent alveolar epithel
Externí odkaz:
https://doaj.org/article/0cd55ce4a07c4a47bf85b736b8a2dc7f
Autor:
Rachel M. Sutton, Humberto Trejo Bittar, Daniel I. Sullivan, Agustin Gil Silva, Harinath Bahudhanapati, Anishka H. Parikh, Yingze Zhang, Kevin Gibson, John F. McDyer, Daniel J. Kass, Jonathan K. Alder
Publikováno v:
Human mutationREFERENCES. 43(12)
The role of constitutional genetic defects in idiopathic pulmonary fibrosis (IPF) is increasingly appreciated. Monogenic disorders associated with IPF affect two pathways: telomere maintenance, accounting for approximately 10% of all patients with IP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256e6b2579143cd6faedabeeac0e9898
https://pubmed.ncbi.nlm.nih.gov/36135709
https://pubmed.ncbi.nlm.nih.gov/36135709
Autor:
Eleanor Valenzi, Harinath Bahudhanapati, Jiangning Tan, Tracy Tabib, Daniel I. Sullivan, Mehdi Nouraie, John Sembrat, Li Fan, Kong Chen, Silvia Liu, Mauricio Rojas, Audrey Lafargue, Dean W. Felsher, Phuoc T. Tran, Daniel J. Kass, Robert Lafyatis
Publikováno v:
European Respiratory Journal. :2200474
BackgroundIn idiopathic pulmonary fibrosis (IPF) myofibroblasts are key effectors of fibrosis and architectural distortion by excessive deposition of extracellular matrix and their acquired contractile capacity. Single-cell RNA-sequencing (scRNA-seq)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78448a030574b799d9ebf28f2b7841bd
https://doi.org/10.1183/13993003.00474-2022
https://doi.org/10.1183/13993003.00474-2022
Publikováno v:
Am J Respir Cell Mol Biol
Type II alveolar epithelial cells (AEC2s) play an essential role in the function and maintenance of the pulmonary epithelium. Several transgenic mice have been developed to study the function of these cells in vivo by using the human SFTPC promoter t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5105e57271f895cae3f617f236c5f32f
https://doi.org/10.1165/rcmb.2019-0416ma
https://doi.org/10.1165/rcmb.2019-0416ma
Autor:
Eleanor Valenzi, Harinath Bahudhanapati, Jiangning Tan, Tracy Tabib, Daniel I. Sullivan, John Sembrat, Li Fan, Kong Chen, Mauricio Rojas, Audrey Lafargue, Dean W. Felsher, Phuoc T. Tran, Daniel J. Kass, Robert Lafyatis
In idiopathic pulmonary fibrosis (IPF) myofibroblasts are key effectors of fibrosis and architectural distortion by excessive deposition of extracellular matrix and their acquired contractile capacity. Single-cell RNA-sequencing has precisely defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad749531089ec90245d7441f0c287e0
https://doi.org/10.1101/2022.01.10.475117
https://doi.org/10.1101/2022.01.10.475117
Autor:
Taylor Adams, Chetan V. Jawale, Jonathan K. Alder, Antje Prasse, Xiaoyun Li, Harinath Bahudhanapati, Apel Rm, Mehdi Nouraie, John F. McDyer, Eleanor Valenzi, John Sembrat, Yanfu Zhang, Daniel I Sullivan, T. Chen, Naftali Kaminski, Partha S. Biswas, Tracy Tabib, Mauricio Rojas, Jiangning Tan, Benjamin Seeliger, Daniel J. Kass, Tedrow J, Robert Lafyatis, Wim A. Wuyts
Signaling via G protein-coupled receptors (GPCRs) can modulate levels of cyclic adenosine monophosphate (cAMP) and shape the functions of fibroblasts in idiopathic pulmonary fibrosis (IPF). We have identified Chemokine (C-X-C) Motif Ligand 6 (CXCL6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::189d1c46aad652976002d27c485100b0
https://doi.org/10.1101/2021.06.22.449424
https://doi.org/10.1101/2021.06.22.449424
Publikováno v:
Journal of Clinical Anesthesia. 54:33-36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab5da8d2c3b17655d117842f98800e21
https://doi.org/10.1016/j.jclinane.2018.10.030
https://doi.org/10.1016/j.jclinane.2018.10.030
Autor:
Daniel I. Sullivan, Mao Jiang, Angela M. Hinchie, Mark G. Roth, Harinath Bahudhanapati, Mehdi Nouraie, Jie Liu, John F. McDyer, Rama K. Mallampalli, Yingze Zhang, Daniel J. Kass, Toren Finkel, Jonathan K. Alder
Publikováno v:
Frontiers in Medicine
Frontiers in Medicine, Vol 8 (2021)
Frontiers in Medicine, Vol 8 (2021)
Cellular senescence due to telomere dysfunction has been hypothesized to play a role in age-associated diseases including idiopathic pulmonary fibrosis (IPF). It has been postulated that paracrine mediators originating from senescent alveolar epithel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2702852236582b22b41b2bae4b5dba19
https://pubmed.ncbi.nlm.nih.gov/33634147
https://pubmed.ncbi.nlm.nih.gov/33634147