Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Autor: María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio

Publikováno v: Hepatology. 77:874-887

Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low-grade inflammation that contributes to the development of diabetes, steatosis, and insulin resistance. Recent research has shown that this chronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f547328426be5b01954e80eb6eeea2
https://doi.org/10.1002/hep.32581

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

Autor: Elsa Maymó-Masip, Victoria Ceperuelo-Mallafré, M. Mar Rodríguez, Joan Vendrell, Miriam Ejarque, Enrique Calvo, Juan Vladimir de la Rosa, Noelia Keiran, María Isabel Hernández-Alvarez, Antonio Zorzano, Gema Medina-Gómez, Daniel Horrillo, Sonia Fernández-Veledo, Catalina Núñez-Roa, Ana Megia, Rosa Fradera, Rosa Jorba, Antonio Castrillo, Carolina Serena

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Succinate is a signaling metabolite sensed extracellularly by succinate receptor 1 (SUNCR1). The accumulation of succinate in macrophages is known to activate a pro-inflammatory program; however, the contribution of SUCNR1 to macrophage phenotype and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8dd4b3ecfd9b51e2b80227f23ca232
https://doi.org/10.1038/s41590-019-0372-7

Peroxisome Proliferator-Activated Receptor γ 2 Modulates Late-Pregnancy Homeostatic Metabolic Adaptations

Autor: Daniel Horrillo, Manuel Ros, Ismael Velasco, Julio Sevillano, Monica Díez-Hochleitner, Mercedes Ricote, María P. Ramos, Adriana Izquierdo-Lahuerta, Cristina Martínez-García, Gema Medina-Gomez, Patricia Corrales, Yurena Vivas, Mark Campbell

Publikováno v: Molecular Medicine, Vol 22, Iss 1, Pp 724-736 (2016)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname

Pregnancy requires adaptation of maternal energy metabolism, including expansion and functional modifications of adipose tissue. Insulin resistance (IR), predominantly during late gestation, is a physiological metabolic adaptation that serves to supp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f9360b9fe6ee37ffd9cea398814c5a
http://link.springer.com/article/10.2119/molmed.2015.00262

Differential Development of Inflammation and Insulin Resistance in Different Adipose Tissue Depots Along Aging in Wistar Rats: Effects of Caloric Restriction

Autor: Teresa Fernández-Agulló, Eva Oliveros, Manuel Ros, José M. Carrascosa, Nuria Lauzurica, Miriam García-San Frutos, Johanna X. Sierra Rojas, Daniel Horrillo

Publikováno v: The journals of gerontology. Series A, Biological sciences and medical sciences. 71(3)

The prevalence of insulin resistance and type 2 diabetes increases with aging and these disorders are associated with inflammation. Insulin resistance and inflammation do not develop at the same time in all tissues. Adipose tissue is one of the tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2885d953158cccdc765f1896b4ec73
https://pubmed.ncbi.nlm.nih.gov/26419977