Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Daniel Homerick"'
Autor:
Philippe Azam, Heike Wulff, Daniel Homerick, Ananthakrishnan Sankaranarayanan, Stephen M Griffey
Publikováno v:
Journal of Investigative Dermatology. 127:1419-1429
The voltage-gated potassium channel Kv1.3 has been recently identified as a molecular target that allows for selective pharmacological suppression of effector memory T (T(EM)) cells without affecting the function of naïve and central memory T cells.
Autor:
Heike Wulff, Christine Beeton, Jamshid Tehranzadeh, Nathan Standifer, Stephen M Griffey, Werner W. Roeck, Christine J. LeeHealey, Philippe Azam, Brian S. Andrews, Alexandra Grino, Debra Counts, K. George Chandy, George A. Gutman, Kimber L. Stanhope, Ananthakrishnan Sankaranarayanan, Ping H. Wang, Katherine M. Mullen, Daniel Homerick, Pavel I. Zimin, Peter J. Havel, Michael W. Pennington, Aaron Kolski-Andreaco, Eric Wei, Peter A. Calabresi, Gerald T. Nepom, Hans Guenther Knaus
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 103, iss 46
Beeton, Christine; Wulff, Heike; Standifer, Nathan E; Azam, Philippe; Mullen, Katherine M; Pennington, Michael W; et al.(2006). Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.. Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17414-17419. doi: 10.1073/pnas.0605136103. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2647b9c5
Beeton, Christine; Wulff, Heike; Standifer, Nathan E; Azam, Philippe; Mullen, Katherine M; Pennington, Michael W; et al.(2006). Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.. Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17414-17419. doi: 10.1073/pnas.0605136103. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2647b9c5
Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune diseases. Here we demonstrate that disease-associated autoreactive T cells from patients with type-1 diabetes mellitus or rheumatoid arthritis (RA) are mainly CD4+CCR7
Publikováno v:
Journal of Medicinal Chemistry. 49:1433-1441
The voltage-gated potassium channel Kv1.3 constitutes an attractive target for the selective suppression of effector memory T cells in autoimmune diseases. We have previously reported the natural product khellinone, 1a, as a versatile lead molecule a
Autor:
Heike Wulff, Yingliang Wu, Violeta Visan, Stéphanie Mouhat, Michel De Waard, Stephan Grissmer, Daniel Homerick, Hervé Darbon, Jean-Marc Sabatier, Georgeta Teodorescu
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, 2006, 69 (1), pp.354-62. ⟨10.1124/mol.105.017210⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2006, 69 (1), pp.354-62. ⟨10.1124/mol.105.017210⟩
Molecular Pharmacology, 2006, 69 (1), pp.354-62. ⟨10.1124/mol.105.017210⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2006, 69 (1), pp.354-62. ⟨10.1124/mol.105.017210⟩
International audience; OSK1, a toxin from the venom of the Asian scorpion Orthochirus scrobiculosus, is a 38-residue peptide cross-linked by three disulfide bridges. A structural analog of OSK1, [Lys(16),Asp(20)]-OSK1, was found previously to be one
Autor:
Ananthakrishnan Sankaranarayanan, Daniel Homerick, Wolfram Hänsel, Heike Wulff, Alexander Schmitz, Philippe Azam, Kristina Schmidt-Lassen
Publikováno v:
Molecular Pharmacology. 68:1254-1270
The lymphocyte K+ channel Kv1.3 constitutes an attractive pharmacological target for the selective suppression of terminally differentiated effector memory T (TEM) cells in T cell-mediated autoimmune diseases, such as multiple sclerosis and type 1 di
Publikováno v:
The FASEB Journal. 21
Publikováno v:
Clinical Immunology. 119:S45-S46