Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Daniel Holoch"'
Autor:
Pierre Romero, Laia Richart, Setareh Aflaki, Ambre Petitalot, Megan Burton, Audrey Michaud, Julien Masliah-Planchon, Frédérique Kuhnowski, Samuel Le Cam, Carlos Baliñas-Gavira, Céline Méaudre, Armelle Luscan, Abderaouf Hamza, Patricia Legoix, Anne Vincent-Salomon, Michel Wassef, Daniel Holoch, Raphaël Margueron
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mutations in chromatin regulators are widespread in cancer. Among them, the histone H3 lysine 27 methyltransferase Polycomb Repressive Complex 2 (PRC2) shows distinct alterations according to tumor type. This specificity is poorly understood
Externí odkaz:
https://doaj.org/article/1b39f7921f8b45b382015dc3a19b069d
Autor:
Andrea Frapporti, Caridad Miró Pina, Olivier Arnaiz, Daniel Holoch, Takayuki Kawaguchi, Adeline Humbert, Evangelia Eleftheriou, Bérangère Lombard, Damarys Loew, Linda Sperling, Karine Guitot, Raphaël Margueron, Sandra Duharcourt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
H3K9me3 and H3K27me3 chromatin silencing marks are usually deposited by different SET-domain proteins. Here the authors show that the Enhancer-of-zeste-like protein Ezl1, from the unicellular eukaryote Paramecium tetraurelia, catalyzes methylation of
Externí odkaz:
https://doaj.org/article/a486884fd7c44e3eb795b8444d15483e
Autor:
Pierre Romero, Laia Richart, Setareh Aflaki, Megan Burton, Audrey Michaud, Julien Masliah-Planchon, Frédérique Kuhnowski, Céline Méaudre, Armelle Luscan, Abderaouf Hamza, Patricia Legoix, Anne Vincent-Salomon, Michel Wassef, Daniel Holoch, Raphaël Margueron
Mutations in chromatin regulators or their histone substrates are widespread in cancer and often play decisive roles in tumorigenesis. These include Polycomb Repressive Complex 2 (PRC2), a histone H3 lysine 27 methyltransferase that shows distinct al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cccdbebd006a04c359ddf5872a66b82
https://doi.org/10.1101/2023.01.02.522460
https://doi.org/10.1101/2023.01.02.522460
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2529
Elucidating the biological function of histone methyltransferases requires knowledge of the genomic sites at which they act. CUTRUN represents a valuable alternative to chromatin immunoprecipitation for the mapping of histone methylation patterns, ge
Autor:
Alexandre, Désert, Karine, Guitot, Audrey, Michaud, Daniel, Holoch, Raphaël, Margueron, Fabienne, Burlina, Dominique, Guianvarc'h
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2529
Identification of histone lysine methyltransferase (HKMT) substrates has recently benefited from chemical-biology-based strategies in which artificial S-adenosyl-L-methionine (SAM) cofactors are engineered to allow substrate labeling using either the
Publikováno v:
Histone Methyltransferases ISBN: 9781071624807
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91c7fa81828cace42a5bea180185a99e
https://doi.org/10.1007/978-1-0716-2481-4_12
https://doi.org/10.1007/978-1-0716-2481-4_12
Autor:
Alexandre Désert, Karine Guitot, Audrey Michaud, Daniel Holoch, Raphaël Margueron, Fabienne Burlina, Dominique Guianvarc’h
Publikováno v:
Histone Methyltransferases ISBN: 9781071624807
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::264d8bb63acbf3af144e3e2e245d5e6f
https://doi.org/10.1007/978-1-0716-2481-4_14
https://doi.org/10.1007/978-1-0716-2481-4_14
Autor:
Adeline Humbert, Daniel Holoch, Andrea Frapporti, Linda Sperling, Sandra Duharcourt, Evangelia Eleftheriou, Olivier Arnaiz, Takayuki Kawaguchi, Damarys Loew, Caridad Miró Pina, Karine Guitot, Raphaël Margueron, Bérangère Lombard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.2710. ⟨10.1038/s41467-019-10648-5⟩
Nature Communications, 2019, 10 (1), pp.2710. ⟨10.1038/s41467-019-10648-5⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.2710. ⟨10.1038/s41467-019-10648-5⟩
Nature Communications, 2019, 10 (1), pp.2710. ⟨10.1038/s41467-019-10648-5⟩
In animals and plants, the H3K9me3 and H3K27me3 chromatin silencing marks are deposited by different protein machineries. H3K9me3 is catalyzed by the SET-domain SU(VAR)3–9 enzymes, while H3K27me3 is catalyzed by the SET-domain Enhancer-of-zeste enz
Autor:
Dina Zielinski, Cecilia Lövkvist, Damarys Loew, Setareh Aflaki, Michel Wassef, Raphaël Margueron, Bérangère Lombard, Daniel Holoch, Tiphaine Hery, Martin Howard
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, In press, ⟨10.1038/s41588-021-00964-2⟩
Nature Genetics, In press, ⟨10.1038/s41588-021-00964-2⟩
Nature Genetics, Nature Publishing Group, In press, ⟨10.1038/s41588-021-00964-2⟩
Nature Genetics, In press, ⟨10.1038/s41588-021-00964-2⟩
Epigenetic inheritance of gene expression states enables a single genome to maintain distinct cellular identities. How histone modifications contribute to this process remains unclear. Using global chromatin perturbations and local, time-controlled m
Autor:
Daniel Holoch, Raphaël Margueron
Publikováno v:
Trends in Biochemical Sciences. 42:531-542
Polycomb repressive complex 2 (PRC2) and its histone H3 lysine-27 methylation activity are crucial for multicellular development by virtue of their role in maintaining transcriptional repression patterns. The recruitment and enzymatic activity of PRC