Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Daniel Hirschhorn Cymerman"'
Autor:
Xia Yang, Taha Merghoub, Sadna Budhu, Roberta Zappasodi, Hong Zhong, Sara Schad, Jedd Wolchok, Daniel Hirschhorn-Cymerman, Mathieu Gigoux, Levi Mangarin, David Redmond, Andrew Chow, Heng Pan, Olivier Elemento
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/d228ad3ef66048f2aeda795e641ab08a
Autor:
Taha Merghoub, Jedd D. Wolchok, Robert Olmsted, Maureen F. Maughan, Shakuntala Tiwari, Daniel Hirschhorn-Cymerman, Nicole Malandro, Sadna Budhu, Arvin Yang, Roberta Zappasodi, Francesca Avogadri
Induction of potent immune responses to self-antigens remains a major challenge in tumor immunology. We have shown that a vaccine based on alphavirus replicon particles (VRP) activates strong cellular and humoral immunity to tyrosinase-related protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f67f6f7cb77e9b9e6530278c4fd00f
https://doi.org/10.1158/2326-6066.c.6548896
https://doi.org/10.1158/2326-6066.c.6548896
Autor:
Taha Merghoub, Jedd D. Wolchok, Robert Olmsted, Maureen F. Maughan, Shakuntala Tiwari, Daniel Hirschhorn-Cymerman, Nicole Malandro, Sadna Budhu, Arvin Yang, Roberta Zappasodi, Francesca Avogadri
PDF file - 428K, Supplementary Figure S1. Depigmentation after combination therapy. Supplementary Figure S2. Tumor immune infiltrate after immunomodulation. Supplementary Figure S3. PD-1 expression on T cell subsets. Supplementary Figure S4. Effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d28c53d772054d517b83ba448696a1
https://doi.org/10.1158/2326-6066.22538794.v1
https://doi.org/10.1158/2326-6066.22538794.v1
Autor:
Jedd D. Wolchok, Jianda D. Yuan, Sacha Gnjatic, James P. Allison, Zhenyu Mu, Chrisann Kyi, Daniel Hirschhorn-Cymerman, Caillian Liu, Takemasa Tsuji, Shigehisa Kitano
PDF file - 144K, Supplemental Figure 1 NY-ESO-1 antigen-specific CD4+ T cell lines were CD8 negative.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405433bff90f9befa4664b8932e3a2f8
https://doi.org/10.1158/2326-6066.22536949.v1
https://doi.org/10.1158/2326-6066.22536949.v1
Autor:
Jedd D. Wolchok, Jianda D. Yuan, Sacha Gnjatic, James P. Allison, Zhenyu Mu, Chrisann Kyi, Daniel Hirschhorn-Cymerman, Caillian Liu, Takemasa Tsuji, Shigehisa Kitano
PDF file - 106K, Supplemental Table 1 Summary of NY-ESO-1 Immune responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419a6224fef0ce11a4a45e40b419b7c9
https://doi.org/10.1158/2326-6066.22536946.v1
https://doi.org/10.1158/2326-6066.22536946.v1
Autor:
Jedd D. Wolchok, Jianda D. Yuan, Sacha Gnjatic, James P. Allison, Zhenyu Mu, Chrisann Kyi, Daniel Hirschhorn-Cymerman, Caillian Liu, Takemasa Tsuji, Shigehisa Kitano
CD4+ T cells provide help to enhance and sustain cytotoxic CD8+ T-cell responses. A direct lytic role for this cell population in mouse models further supports the use of tumor-reactive CD4+ T cells for cancer immunotherapy. CTLA-4 blockade has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c71f7af6f2fd4e3a6073689978fc7f5a
https://doi.org/10.1158/2326-6066.c.6548284.v1
https://doi.org/10.1158/2326-6066.c.6548284.v1
Autor:
Jedd D. Wolchok, Taha Merghoub, Alan N. Houghton, Eric G. Pamer, John J. Lazarus, Gabrielle A. Rizzuto, Francesca Avogadri, Daniel Hirschhorn-Cymerman, Czrina Cortez, Shigehisa Kitano, Tobias M. Hohl, Alexander M. Lesokhin
PDF file - 1.8MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9551f83db4c5caa91606d8e1f32c79c9
https://doi.org/10.1158/0008-5472.22391825
https://doi.org/10.1158/0008-5472.22391825
Autor:
Taha Merghoub, David Redmond, Daniel Hirschhorn-Cymerman, Sara Schad, Mathieu Gigoux, Olivier Elemento, Jedd D. Wolchok, Xia Yang, Andrew Chow, Hong Zhong, Roberta Zappasodi, Sadna Budhu, Levi Mangarin, Heng Pan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background CD4 and CD8 T cells are genetically and functionally distinct cell subsets of the adaptive immune system that play pivotal roles in immune surveillance and disease control. During development in the thymus, transcription factors ThPOK and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db990b66524a278369181b14d3e8e036
https://doi.org/10.1136/jitc-2020-sitc2020.0549
https://doi.org/10.1136/jitc-2020-sitc2020.0549
Autor:
Francesca Avogadri, Taha Merghoub, Maureen F Maughan, Daniel Hirschhorn-Cymerman, John Morris, Erika Ritter, Robert Olmsted, Alan N Houghton, Jedd D Wolchok
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
BACKGROUND:Malignant melanoma is the deadliest form of skin cancer and is refractory to conventional chemotherapy and radiotherapy. Therefore alternative approaches to treat this disease, such as immunotherapy, are needed. Melanoma vaccine design has
Externí odkaz:
https://doaj.org/article/47ed58a42bff4fa9a6e1ec424847c778
Autor:
Jean Albrengues, Cailian Liu, Gabrielle Rizzuto, Olivier De Henau, Allison Betof Warner, Arshi Arora, Sadna Budhu, Daniel Hirschhorn-Cymerman, Katherine S. Panageas, David Schröder, Billel Gasmi, Czrina Cortez, Jacob Ricca, Aliya Holland, Levi Mangarin, Travis J. Hollmann, Yanyun Li, Mikala Egeblad, David Redmond, Mathieu Gigoux, Taha Merghoub, Jedd D. Wolchok
Publikováno v:
SSRN Electronic Journal.
Targeted immune therapies such as adoptive T cell transfer (ACT) are often ineffective because tumors evolve over time under selective pressure to display antigen loss variant. A classic example is de-differentiation and loss of expression of antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aaf71d873902ab9783f470682ad880b
https://doi.org/10.2139/ssrn.3596599
https://doi.org/10.2139/ssrn.3596599