Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Daniel Hilger"'
Autor:
Zoe Köck, Kilian Schnelle, Margherita Persechino, Simon Umbach, Hannes Schihada, Dovile Januliene, Kristian Parey, Steffen Pockes, Peter Kolb, Volker Dötsch, Arne Möller, Daniel Hilger, Frank Bernhard
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Here we describe the cryo-electron microscopy structure of the human histamine 2 receptor (H2R) in an active conformation with bound histamine and in complex with Gs heterotrimeric protein at an overall resolution of 3.4 Å. The complex was
Externí odkaz:
https://doaj.org/article/445a6baea17e4eda9466e6412e55e11b
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/89cf7a89feda4b1daa48d2ee6f888fb9
Autor:
Alpay Burak Seven, Daniel Hilger, Makaía M. Papasergi-Scott, Li Zhang, Qianhui Qu, Brian K. Kobilka, Gregory G. Tall, Georgios Skiniotis
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3699-3709.e6 (2020)
Summary: Many chaperones promote nascent polypeptide folding followed by substrate release through ATP-dependent conformational changes. Here we show cryoEM structures of Gα subunit folding intermediates in complex with full-length Ric-8A, a unique
Externí odkaz:
https://doaj.org/article/17f4656dd6a64188bc8fbddf98884eac
Autor:
Shoji Maeda, Antoine Koehl, Hugues Matile, Hongli Hu, Daniel Hilger, Gebhard F. X. Schertler, Aashish Manglik, Georgios Skiniotis, Roger J. P. Dawson, Brian K. Kobilka
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The determination of high resolution structures of G protein coupled receptors (GPCRs) in complex with heterotrimeric G proteins is challenging. Here authors develop an antibody fragment, mAB16, which stabilizes GPCR/G-protein complexes and facilitat
Externí odkaz:
https://doaj.org/article/78767849a46d4536a969df36dd817784
Publikováno v:
Proceedings in applied mathematics and mechanics : PAMM 23(1), e202200069 (2023). doi:10.1002/pamm.202200069 special issue: "Special Issue: 92nd Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM) / Issue Edited by: Ch. Böhm, K. Mang, B. Markert, S. Reese, M. Schmidtchen, J. Waimann, M. Kaliske"
92. Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), PAMM 2022, Aachen, Germany, 2022-08-15-2022-08-19
92. Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), PAMM 2022, Aachen, Germany, 2022-08-15-2022-08-19
92. Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), GAMM, Aachen, Germany, 15 Aug 2022 - 19 Aug 2022; Proceedings in applied mathematics and mechanics : PAMM 23(1), e202200069 (2023). doi:10.1002/pamm.2022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199086c191f100a3f60245311012ec63
https://doi.org/10.1002/pamm.202200069
https://doi.org/10.1002/pamm.202200069
Autor:
Makaía M. Papasergi-Scott, Guillermo Pérez-Hernández, Hossein Batebi, Yang Gao, Gözde Eskici, Alpay B. Seven, Ouliana Panova, Daniel Hilger, Marina Casiraghi, Feng He, Luis Maul, Peter Gmeiner, Brian K. Kobilka, Peter W. Hildebrand, Georgios Skiniotis
Publikováno v:
bioRxiv
SummaryG protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating the exchange of guanine nucleotide in the Gα subunit. To visualize this mechanism, we developed a time-resolved cryo-EM approach that examines the progressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6024f692aea102cdca85b66e07b494c8
https://doi.org/10.1101/2023.03.20.533387
https://doi.org/10.1101/2023.03.20.533387
Autor:
Christian Idzik, Daniel Hilger, Norbert Hosters, Marco Kemmerling, Philipp Niemietz, Lucia Ortjohann, Jana Sasse, Alexandros Serafeim, Jing Wang, Daniel Wolff, Gerhard Hirt
Publikováno v:
Internet of Production ISBN: 9783030980627
Decision support systems can provide real-time process information and correlations, which in turn assists process experts in making decisions and thus further increase productivity. This also applies to well-established and already highly automated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a7670f4341bd71d356f828448f2f878
https://doi.org/10.1007/978-3-030-98062-7_12-1
https://doi.org/10.1007/978-3-030-98062-7_12-1
Autor:
Sarah Paisdzior, Jörg Bürger, Michal Szczepek, Daniel Hilger, Brian Bauer, Annette G. Beck-Sickinger, T. Hilal, Anja Koch, Nicolas A. Heyder, Christian M. T. Spahn, Magdalena Schacherl, Peter Kühnen, Heike Biebermann, Dennis Kwiatkowski, Andrea Schmidt, Monique Gallandi, David Speck, Peter W. Hildebrand, Thorsten Mielke, Brian K. Kobilka, Gunnar Kleinau, Patrick Scheerer
Publikováno v:
Cell Research
The melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy homeostasis and appetite, is a class A G-protein-coupled receptor and a prime target for the pharmacological treatment of obesity. Here, we present cryo-electron microscopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3cac4619722e65c3857cb94f1c7078
https://doi.org/10.1038/s41422-021-00569-8
https://doi.org/10.1038/s41422-021-00569-8
Autor:
Daniel Hilger
Publikováno v:
Cell Research. 33:191-192
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1069bf2cf39c3fd353fb4ae5ffc9a909
https://doi.org/10.1038/s41422-022-00767-y
https://doi.org/10.1038/s41422-022-00767-y
Autor:
Daniel Hilger
Publikováno v:
The FEBS Journal. 288:2461-2489
G protein-coupled receptors (GPCRs) play critical roles in the regulation of human physiology in response to a wide array of different extracellular stimuli and thus represent one of the largest groups of therapeutic drug targets. Recent advances in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82fbd19e454041a8b1c5ea665dae755
https://doi.org/10.1111/febs.15841
https://doi.org/10.1111/febs.15841