Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Daniel Herkommer"'
2
Total Synthesis of Leupyrrins A1and B1, Highly Potent Antifungal Agents from the MyxobacteriumSorangium cellulosum
Autor: Maoqun Tian, Tongtong Wang, Thomas Debnar, Sebastian Thiede, Daniel Herkommer, Michael Schrempp, Dirk Menche, Paul R. Wosniok
Publikováno v: Chemistry - A European Journal. 23:3300-3320
Full details on the design, elaboration, and application of efficient strategies for the high-yielding total syntheses of leupyrrins A1 and B1 , unique antifungal agents from the myxobacterium Sorangium cellulosum, are reported. A sequential zirconoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0be286e008d18e8a3970961d3c9184f5
https://doi.org/10.1002/chem.201604445
Zobrazit plný text záznamu
3
Enantioselective Formation of All-Carbon Quaternary Centers via C–H Functionalization of Methanol: Iridium-Catalyzed Diene Hydrohydroxymethylation
Autor: Khoa D. Nguyen, Michael J. Krische, Daniel Herkommer
Publikováno v: Journal of the American Chemical Society. 138:14210-14213
The first catalytic enantioselective C-C couplings of methanol (> 30× 106 tons/year) are reported. Formal insertion of 2-substituted dienes into the methanol C–H bond occurs in a regioselective manner to form all-carbonyl quaternary centers with e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4276a9ea10267403b8a5e0161e394a59
https://doi.org/10.1021/jacs.6b09333
Zobrazit plný text záznamu
4
Total Synthesis of Leupyrrin B1: A Potent Inhibitor of Human Leukocyte Elastase
Autor: Michael Gütschow, Dirk Menche, Daniel Herkommer, Anna-Christina Schulz-Fincke, Sebastian Thiede, Paul R. Wosniok
Publikováno v: Organic Letters. 18:3964-3967
The total synthesis of leupyrrin B1 was accomplished by an expedient strategy that involves an optimized HATU-mediated amide coupling protocol of elaborate substrates. The generally useful procedure was also successfully applied in an improved total
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5a1dd8451203c0c7cc24eb15285595
https://doi.org/10.1021/acs.orglett.6b01724
Zobrazit plný text záznamu
5
Ruthenium-BINAP Catalyzed Alcohol C–H tert-Prenylation via 1,3-Enyne Transfer Hydrogenation: Beyond Stoichiometric Carbanions in Enantioselective Carbonyl Propargylation
Autor: Khoa D. Nguyen, Michael J. Krische, Daniel Herkommer
Publikováno v: Journal of the American Chemical Society. 138:5238-5241
The chiral ruthenium complex formed in situ from (TFA)2Ru(CO)(PPh3)2 and (R)-BINAP is found to catalyze the enantioselective C-C coupling of diverse primary alcohols with the 1,3-enyne, TMSC≡CC(Me)=CH2, to form secondary homopropargyl alcohols bear
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6c6382d0bd6ad59bda14a92772e8de
https://doi.org/10.1021/jacs.6b02279
Zobrazit plný text záznamu
6
Design, Synthesis, and Biological Evaluation of Simplified Side Chain Hybrids of the Potent Actin Binding Polyketides Rhizopodin and Bistramide
Autor: Daniel Herkommer, Holger Gohlke, Dirk Menche, Galina Sergeev, Sandra Dreisigacker, Florenz Sasse
Publikováno v: ChemMedChem. 10:470-489
The natural products rhizopodin and bistramide belong to an elite class of highly potent actin binding agents. They show powerful antiproliferative activities against a range of tumor cell lines, with IC50 values in the low-nanomolar range. At the mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576eacf76ec2e906f9d965f23953794b
https://doi.org/10.1002/cmdc.201402508
Zobrazit plný text záznamu
7
Modular Total Synthesis of Rhizopodin: A Highly Potent G-Actin Dimerizing Macrolide
Autor: Dirk Menche, Manuel Kretschmer, Michael Dieckmann, Daniel Herkommer, Pengfei Li, Johannes Troendlin, Sven Rudolph
Publikováno v: Chemistry - A European Journal. 19:15993-16018
A highly convergent total synthesis of the potent polyketide macrolide rhizopodin has been achieved in 29 steps by employing a concise strategy that exploits the molecule's C2 symmetry. Notable features of this convergent approach include a rapid ass
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7d071d0b3f00ba99ce9b5897aa109e
https://doi.org/10.1002/chem.201302197
Zobrazit plný text záznamu
8
ChemInform Abstract: Ruthenium-BINAP Catalyzed Alcohol C-H tert-Prenylation via 1,3-Enyne Transfer Hydrogenation: Beyond Stoichiometric Carbanions in Enantioselective Carbonyl Propargylation
Autor: Michael J. Krische, Khoa D. Nguyen, Daniel Herkommer
Publikováno v: ChemInform. 47
The chiral ruthenium complex formed in situ from (TFA)2Ru(CO)(PPh3)2 and (R)-BINAP is found to catalyze the enantioselective C–C coupling of diverse primary alcohols with the 1,3-enyne, TMSC≡CC(Me)═CH2, to form secondary homopropargyl alcohols
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::690bb119e72cc0ff900d63b886767839
https://doi.org/10.1002/chin.201640202
Zobrazit plný text záznamu
10
Total Synthesis of Rhizopodin
Autor: Dirk Menche, Michael Dieckmann, Manuel Kretschmer, Pengfei Li, Daniel Herkommer, Sven Rudolph
Publikováno v: Angewandte Chemie International Edition. 51:5667-5670
Rhizopodin (1, Scheme 1) is an architecturally unique polyketide macrolide that was originally isolated from the myxobacterium Myxococcus stipitatus by the groups of Hcfle and Reichenbach. It shows potent antifungal and antiproliferative cytotoxicity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655e889c36ee4a3683decb8b377053c2
https://doi.org/10.1002/anie.201201946
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje