Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Daniel Heine"'
Autor:
Daniel Heine, Neil A. Holmes, Sarah F. Worsley, Ana Carolina A. Santos, Tabitha M. Innocent, Kirstin Scherlach, Elaine H. Patrick, Douglas W. Yu, J. Colin Murrell, Paulo C. Vieria, Jacobus J. Boomsma, Christian Hertweck, Matthew I. Hutchings, Barrie Wilkinson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Acromyrmex ants cultivate fungus gardens that can be parasitized by Escovopsis sp., leading to colony collapse. Here, Heine et al. identify two secondary metabolites produced by Escovopsis that accumulate in Acromyrmex tissue, reduce behavioural defe
Externí odkaz:
https://doaj.org/article/2e969411613d435eba4ecc55f43f0883
Autor:
Aleksandra Wlodek, Steve G. Kendrew, Nigel J. Coates, Adam Hold, Joanna Pogwizd, Steven Rudder, Lesley S. Sheehan, Sarah J. Higginbotham, Anna E. Stanley-Smith, Tony Warneck, Mohammad Nur-E-Alam, Markus Radzom, Christine J. Martin, Lois Overvoorde, Markiyan Samborskyy, Silke Alt, Daniel Heine, Guy T. Carter, Edmund I. Graziani, Frank E. Koehn, Leonard McDonald, Alexander Alanine, Rosa María Rodríguez Sarmiento, Suzan Keen Chao, Hasane Ratni, Lucinda Steward, Isobel H. Norville, Mitali Sarkar-Tyson, Steven J. Moss, Peter F. Leadlay, Barrie Wilkinson, Matthew A. Gregory
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.
Externí odkaz:
https://doaj.org/article/b36ef21246ab47bfb8cbd4e969caea7c
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Obafluorin is a β-lactone antibiotic produced byPseudomonas fluorescens. Here the authors present the biosynthetic gene cluster and biosynthetic pathway of obafluorin, which is characterized by a central transaldolase step catalysed by a rare L-thre
Externí odkaz:
https://doaj.org/article/7b242d2ca4034e769a1c3a08715872de
Autor:
Nicolle F. Som, Daniel Heine, Neil A. Holmes, John T. Munnoch, Govind Chandra, Ryan F. Seipke, Paul A. Hoskisson, Barrie Wilkinson, Matthew I. Hutchings
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Streptomyces bacteria make numerous secondary metabolites, including half of all known antibiotics. Production of antibiotics is usually coordinated with the onset of sporulation but the cross regulation of these processes is not fully understood. Th
Externí odkaz:
https://doaj.org/article/150e51c10e1a4f9c9bd81308b48430f2
Autor:
Markus Gressler, Florian Meyer, Daniel Heine, Peter Hortschansky, Christian Hertweck, Matthias Brock
Publikováno v:
eLife, Vol 4 (2015)
Secondary metabolites have a great potential as pharmaceuticals, but there are only a few examples where regulation of gene cluster expression has been correlated with ecological and physiological relevance for the producer. Here, signals, mediators,
Externí odkaz:
https://doaj.org/article/c2f920e2e8844e68acb2022044bcbb93
Autor:
Friederike Holderried, Daniel Heine, Robert Wagner, Moritz Mahling, Yelena Fenik, Anne Herrmann-Werner, Reimer Riessen, Peter Weyrich, Stephan Zipfel, Nora Celebi
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89198 (2014)
BACKGROUND: Patient chart review is the gold standard for detection of potential patient hazards (i.e. medication errors or failure to follow up actionable results) in both routine clinical care and patient safety research. However, advanced medical
Externí odkaz:
https://doaj.org/article/e48b2381e95f4630a6b3a32964b4dd27
Akademický článek
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Autor:
Daniel Heine, David A. Widdick, Neil A. Holmes, Eleni Vikeli, Sibyl F. D. Batey, Naomi E. Pierce, Barrie Wilkinson, Dino J. Martins, Mervyn J. Bibb, Matthew I. Hutchings
Publikováno v:
Applied and Environmental Microbiology
The discovery of novel antibiotics to tackle the growing threat of antimicrobial resistance is impeded by difficulties in accessing the full biosynthetic potential of microorganisms. The development of new tools to unlock the biosynthesis of cryptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c20371334355ff146f233c5c0bdf50f
https://ueaeprints.uea.ac.uk/id/eprint/72922/
https://ueaeprints.uea.ac.uk/id/eprint/72922/
Autor:
Daniel Heine, Ruth Bauer, Hak Joong Kim, Srividhya Sundaram, Christian Hertweck, Tawatchai Thongkongkaew
Publikováno v:
Angewandte Chemie. 130:11393-11397
Ketosynthase (KS) domains of modular type I polyketide synthases (PKSs) typically catalyze the Claisen condensation of acyl and malonyl units to form linear chains. In stark contrast, the KS of the rhizoxin PKS branching module mediates a Michael add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdecfc202f28bf607b57c8bea1c614f
https://doi.org/10.1002/ange.201804991
https://doi.org/10.1002/ange.201804991
Autor:
Matthew J. Rames, John P. Kenison, Daniel Heineck, Fehmi Civitci, Malwina Szczepaniak, Ting Zheng, Julia Shangguan, Yujia Zhang, Kai Tao, Sadik Esener, Xiaolin Nan
Publikováno v:
Chemical & Biomedical Imaging, Vol 1, Iss 9, Pp 817-830 (2023)
Externí odkaz:
https://doaj.org/article/568c13286eed4834b37953c156f16fa8