A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products.

Autor: Bhardwaj M; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536., Cui Z; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536., Daniel Hankore E; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536., Moonschi FH; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536., Saghaeiannejad Esfahani H; Department of Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY 40536., Kalkreuter E; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458., Gui C; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458., Yang D; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458.; Natural Products Discovery Center, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458., Phillips GN Jr; Department of BioSciences, Rice University, Houston, TX 77005., Thorson JS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536., Shen B; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458.; Natural Products Discovery Center, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458.; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458.; Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, Jupiter, FL 33458., Van Lanen SG; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536.; Department of Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY 40536.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Feb 28; Vol. 120 (9), pp. e2220468120. Date of Electronic Publication: 2023 Feb 21.