Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Daniel Haensel"'
Autor:
Daniel Haensel, Bence Daniel, Sadhana Gaddam, Cory Pan, Tania Fabo, Jeremy Bjelajac, Anna R. Jussila, Fernanda Gonzalez, Nancy Yanzhe Li, Yun Chen, JinChao Hou, Tiffany Patel, Sumaira Aasi, Ansuman T. Satpathy, Anthony E. Oro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Cancer immunotherapies have revolutionized treatment but have shown limited success as single-agent therapies highlighting the need to understand the origin, assembly, and dynamics of heterogeneous tumor immune niches. Here, we use single-ce
Externí odkaz:
https://doaj.org/article/5e4bc24e6e914f23800da67601a21438
Autor:
Daniel Haensel, Sadhana Gaddam, Nancy Y. Li, Fernanda Gonzalez, Tiffany Patel, Jeffrey M. Cloutier, Kavita Y. Sarin, Jean Y. Tang, Kerri E. Rieger, Sumaira Z. Aasi, Anthony E. Oro
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The identification of distinct cell populations with cellular plasticity in skin basal cell carcinoma is important for understanding treatment resistance mechanisms. Here, the authors identify the resistant LY6D+ basosquamous population that correlat
Externí odkaz:
https://doaj.org/article/6d2473dc2a7c4d1f861884ab46dca408
Autor:
Catherine D. Yao, Daniel Haensel, Sadhana Gaddam, Tiffany Patel, Scott X. Atwood, Kavita Y. Sarin, Ramon J. Whitson, Siegen McKellar, Gautam Shankar, Sumaira Aasi, Kerri Rieger, Anthony E. Oro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Basal cell carcinoma (BCC) cells with increased nuclear myocardin-related transcription factor (nMRTF) levels are resistant to Smoothened inhibitors, however how MRTF activity is regulated is still elusive. Here, the authors identify a LYPD3+/TACSTD2
Externí odkaz:
https://doaj.org/article/e6b18a583afe4ea5bde3d4d2f73b777e
Autor:
François Kuonen, Nancy Yanzhe Li, Daniel Haensel, Tiffany Patel, Sadhana Gaddam, Laura Yerly, Kerri Rieger, Sumaira Aasi, Anthony E. Oro
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109774- (2021)
Summary: While squamous transdifferentiation within subpopulations of adenocarcinomas represents an important drug resistance problem, its underlying mechanism remains poorly understood. Here, using surface markers of resistant basal cell carcinomas
Externí odkaz:
https://doaj.org/article/9aa5bd39daa94ef991f899bb661af1b2
Autor:
Daniel Haensel, Suoqin Jin, Peng Sun, Rachel Cinco, Morgan Dragan, Quy Nguyen, Zixuan Cang, Yanwen Gong, Remy Vu, Adam L. MacLean, Kai Kessenbrock, Enrico Gratton, Qing Nie, Xing Dai
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3932-3947.e6 (2020)
Summary: Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and drive wound healing. Previous studies have probed basal cell hete
Externí odkaz:
https://doaj.org/article/6caeceadf7a841d9be133cf785ca5f1b
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1006006 (2018)
The mammalian skin epidermis is a stratified epithelium composed of multiple layers of epithelial cells that exist in appropriate sizes and proportions, and with distinct boundaries separating each other. How the epidermis develops from a single laye
Externí odkaz:
https://doaj.org/article/6b5eb0339e9a456a906473a099926f33
Autor:
Yanwen Gong, Kai Kessenbrock, Quy H. Nguyen, Remy Vu, Xing Dai, Adam L. MacLean, Zixuan Cang, Suoqin Jin, Peng Sun, Daniel Haensel, Enrico Gratton, Qing Nie, Rachel Cinco, Morgan Dragan
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3932-3947.e6 (2020)
Cell reports
Cell reports, vol 30, iss 11
Cell reports
Cell reports, vol 30, iss 11
SUMMARY Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and drive wound healing. Previous studies have probed basal cell heter
Autor:
Remy Vu, Suoqin Jin, Peng Sun, Daniel Haensel, Quy Hoa Nguyen, Morgan Dragan, Kai Kessenbrock, Qing Nie, Xing Dai
Publikováno v:
Cell reports, vol 40, iss 5
Delayed and often impaired wound healing in the elderly presents major medical and socioeconomic challenges. A comprehensive understanding of the cellular/molecular changes that shape complex cell-cell communications in aged skin wounds is lacking. H
Autor:
Eric Pearlman, Zeyu Chen, Kai Kessenbrock, Guadalupe Gutierrez, Remy Vu, Morgan Dragan, Daniel Haensel, Elyse Noelani Greenberg, Peng Sun, Yuling Shi, Xing Dai, Quy H. Nguyen, Jie Wu, Wei Han, Scott X. Atwood
Publikováno v:
The Journal of investigative dermatology, vol 141, iss 6
J Invest Dermatol
J Invest Dermatol
Psoriasis is a common inflammatory skin disease characterized by aberrant inflammation and epidermal hyperplasia. Molecular mechanisms that regulate psoriasis-like skin inflammation remain to be fully understood. Here, we show that the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee5e23afd4dc78ec4a6b6a2db27135a
https://escholarship.org/uc/item/4673b0x9
https://escholarship.org/uc/item/4673b0x9
Autor:
Daniel Haensel, Anthony E. Oro
Publikováno v:
Nat Cell Biol
Stem cells tightly link their metabolism to cell fate decisions; however, how cancers co-opt and bypass metabolic pathways for growth advantage remains unclear. New evidence in this issue highlights how cancer stem cells avoid epigenetically driven d