Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniel H.-C. Chen"'
Publikováno v:
Noise and Health, Vol 16, Iss 73, Pp 400-409 (2014)
Noise-induced hearing loss (NIHL) is a major public health issue worldwide. Uncovering the early molecular events associated with NIHL would reveal mechanisms leading to the hearing loss. Our aim is to investigate the immediate molecular responses af
Externí odkaz:
https://doaj.org/article/2081a59c37d347b08e06b203abb95f2a
Autor:
David F. Fischer, Ruishuang Geng, Daniel H-C Chen, Krista Ouwehand, Esmieu William R K, Krzysztof Palczewski, Masaru Miyagi, Faywell Albertus, Suhasini R. Gopal, Andrew Pate Owens, Guilian Tian, Roland Bürli, Yoshikazu Imanishi, Angus M MacLeod, Kumar N. Alagramam, Nicola A Lindsay, Richard Lee, William E. Harte, Ina Nemet, Karine Fabienne Malagu, Christopher James Lock
Publikováno v:
Nature Chemical Biology. 12:444-451
Usher syndrome type III (USH3), characterized by progressive deafness, variable balance disorder and blindness, is caused by destabilizing mutations in the gene encoding the clarin-1 (CLRN1) protein. Here we report a new strategy to mitigate hearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd625ab815b871a28799293b9f41b5a7
https://doi.org/10.1038/nchembio.2069
https://doi.org/10.1038/nchembio.2069
Autor:
Akil Omar, Ruben Stepanyan, Suhasini R. Gopal, Martin L. Basch, Ruishuang Geng, David A. Saperstein, Kumar N. Alagramam, William W. Hauswirth, David N. Furness, Astra Dinculescu, Daniel H.-C. Chen, Lawrence R. Lustig
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Usher syndrome type III (USH3) characterized by progressive loss of vision and hearing is caused by mutations in the clarin-1 gene (CLRN1). Clrn1 knockout (KO) mice develop hair cell defects by postnatal day 2 (P2) and are deaf by P21-P25. Early onse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e778581a980b0c5e1ed6d8fe03991bf
https://pubmed.ncbi.nlm.nih.gov/29044151
https://pubmed.ncbi.nlm.nih.gov/29044151
Autor:
Geoff Horwitz, Yoshikazu Imanishi, Tomoko Oshima-Takago, Ruishuang Geng, David N. Furness, Jeffrey R. Holt, Sami Melki, Kumar N. Alagramam, Charles Askew, Jakob Neef, Tobias Moser, Guilian Tian, Daniel H.-C. Chen
Publikováno v:
Journal of Neuroscience. 32:9485-9498
Mutation in the clarin-1 gene (Clrn1) results in loss of hearing and vision in humans (Usher syndrome III), but the role of clarin-1 in the sensory hair cells is unknown. Clarin-1 is predicted to be a four transmembrane domain protein similar to memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26aa891d7603fe40558630bb9019b3d8
https://doi.org/10.1523/jneurosci.0311-12.2012
https://doi.org/10.1523/jneurosci.0311-12.2012
Publikováno v:
Developmental Neuroscience. 29:251-260
Genetic, noise- and drug-induced loss of hair cells in the mouse and human cochlea leads to permanent hearing loss due to lack of regeneration of hair cells, which may be due to reduced numbers or loss of the regenerative ability of stem cells in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f7ee17abc0f61be40cf66fc12e1da8
https://doi.org/10.1159/000096415
https://doi.org/10.1159/000096415
Publikováno v:
BJU International. 94:637-650
OBJECTIVES To investigate, in an initial study, the use of microarray analysis (MA) to develop an information base for urolithiasis. MA enables the screening of thousands of genes simultaneously making it the technique of choice for situations where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ea94c629e039a12e9a5db1d1293694
https://doi.org/10.1111/j.1464-410x.2004.05016.x
https://doi.org/10.1111/j.1464-410x.2004.05016.x
Publikováno v:
The Journal of Urology. :2192-2197
Purpose: Tamm-Horsfall protein is believed to inhibit calcium oxalate crystallization, aggregation or adhesion to the renal epithelium. We determined whether ethylene glycol induced urolithiasis changes the expression of renal and urinary Tamm-Horsfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc5808ffd049a8500afb8d8002122b5
https://doi.org/10.1097/00005392-200205000-00070
https://doi.org/10.1097/00005392-200205000-00070
Publikováno v:
Noise and Health, Vol 16, Iss 73, Pp 400-409 (2014)
Noise-induced hearing loss (NIHL) is a major public health issue worldwide. Uncovering the early molecular events associated with NIHL would reveal mechanisms leading to the hearing loss. Our aim is to investigate the immediate molecular responses af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679f3ab84024bf30f15a6d2f92db6b3d
https://pubmed.ncbi.nlm.nih.gov/25387536
https://pubmed.ncbi.nlm.nih.gov/25387536
Autor:
Lynn M. Mink, Barry C. Mita, Daniel H. C. Chen, Matthew C. Stewart, Xiaolan Zhou, R. Tracy Ballock
Publikováno v:
Endocrinology. 141:4552-4557
A growing body of evidence suggests that systemic hormones and peptide growth factors may exert their effects on cell growth and differentiation in part through regulation of the cell division cycle. We hypothesized that thyroid hormone regulates ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2344baf30dcfdc9be98c61b6a5cde0
https://doi.org/10.1210/endo.141.12.7839
https://doi.org/10.1210/endo.141.12.7839
Publikováno v:
Journal of Bone and Mineral Research. 14:1550-1556
Although thyroid hormone has been known for many years to be a potent regulator of skeletal maturation in vivo, it has not definitively been determined whether this effect is a result of a direct or indirect action of the hormone. Previous in vivo st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78695cd7dbcc189c441231a9bc9552ce
https://doi.org/10.1359/jbmr.1999.14.9.1550
https://doi.org/10.1359/jbmr.1999.14.9.1550