Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Daniel H. Park"'
Autor:
Daniel H. Park, Kevin Liaw, Pratik Bhojnagarwala, Xizhou Zhu, Jihae Choi, Ali R. Ali, Devivasha Bordoloi, Ebony N. Gary, Ryan P. O’Connell, Abhijeet Kulkarni, Diana Guimet, Trevor Smith, Alfredo Perales-Puchalt, Ami Patel, David B. Weiner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 249-263 (2023)
Glioblastoma multiforme (GBM) is among the most difficult cancers to treat with a 5-year survival rate less than 5%. An immunotherapeutic vaccine approach targeting GBM-specific antigen, EGFRvIII, previously demonstrated important clinical impact. Ho
Externí odkaz:
https://doaj.org/article/711f820743e943359c7145d81fe55987
Autor:
Xizhou Zhu, Alfredo Perales-Puchalt, Krzysztof Wojtak, Ziyang Xu, Kun Yun, Pratik S. Bhojnagarwala, Devivasha Bordoloi, Daniel H. Park, Kevin Liaw, Mamadou A. Bah, Paul M. Lieberman, Ebony N. Gary, Ami Patel, David B. Weiner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 218-229 (2022)
Latent Epstein-Barr virus (EBV) infection is associated with several types of cancer. Several clinical studies have targeted EBV antigens as immune therapeutic targets with limited efficacy of EBV malignancies, suggesting that additional targets migh
Externí odkaz:
https://doaj.org/article/f6f4c101657c4f7aa88799ba04927cda
Autor:
Nicholas J. Tursi, Ziyang Xu, Michaela Helble, Susanne Walker, Kevin Liaw, Neethu Chokkalingam, Toshitha Kannan, Yuanhan Wu, Edgar Tello-Ruiz, Daniel H. Park, Xizhou Zhu, Megan C. Wise, Trevor R. F. Smith, Sonali Majumdar, Andrew Kossenkov, Daniel W. Kulp, David B. Weiner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cancer immunotherapy has demonstrated great promise with several checkpoint inhibitors being approved as the first-line therapy for some types of cancer, and new engineered cytokines such as Neo2/15 now being evaluated in many studies. In this work,
Externí odkaz:
https://doaj.org/article/dc3a4e20f8a14ad0a03f68a1e21315d0
Autor:
Devivasha Bordoloi, Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Abhijeet J. Kulkarni, Xizhou Zhu, Kevin Liaw, Ryan P. O’Connell, Daniel H. Park, Daniel W. Kulp, Rugang Zhang, David B. Weiner
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Despite advances in ovarian cancer (OC) therapy, recurrent OC remains a poor-prognosis disease. Because of the close interaction between OC cells and the tumor microenvironment (TME), it is important to develop strategies that target tumor cells and
Externí odkaz:
https://doaj.org/article/a607704c926640839bde5206f6333f01
Autor:
Trevor R. F. Smith, Ami Patel, Stephanie Ramos, Dustin Elwood, Xizhou Zhu, Jian Yan, Ebony N. Gary, Susanne N. Walker, Katherine Schultheis, Mansi Purwar, Ziyang Xu, Jewell Walters, Pratik Bhojnagarwala, Maria Yang, Neethu Chokkalingam, Patrick Pezzoli, Elizabeth Parzych, Emma L. Reuschel, Arthur Doan, Nicholas Tursi, Miguel Vasquez, Jihae Choi, Edgar Tello-Ruiz, Igor Maricic, Mamadou A. Bah, Yuanhan Wu, Dinah Amante, Daniel H. Park, Yaya Dia, Ali Raza Ali, Faraz I. Zaidi, Alison Generotti, Kevin Y. Kim, Timothy A. Herring, Sophia Reeder, Viviane M. Andrade, Karen Buttigieg, Gan Zhao, Jiun-Ming Wu, Dan Li, Linlin Bao, Jiangning Liu, Wei Deng, Chuan Qin, Ami Shah Brown, Makan Khoshnejad, Nianshuang Wang, Jacqueline Chu, Daniel Wrapp, Jason S. McLellan, Kar Muthumani, Bin Wang, Miles W. Carroll, J. Joseph Kim, Jean Boyer, Daniel W. Kulp, Laurent M. P. F. Humeau, David B. Weiner, Kate E. Broderick
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
There is currently no licensed SARS-CoV-2 vaccine. Here, the authors generate an optimized DNA vaccine candidate encoding the SARS-CoV-2 spike antigen, demonstrating induction of specific T cells and neutralizing antibody responses in mice and guinea
Externí odkaz:
https://doaj.org/article/0814bda6deff4859a14eda518fea5941
Autor:
Ami Patel, Antonio DiGiandomenico, Ashley E. Keller, Trevor R. F. Smith, Daniel H. Park, Stephanie Ramos, Katherine Schultheis, Sarah T. C. Elliott, Janess Mendoza, Kate E. Broderick, Megan C. Wise, Jian Yan, Jingjing Jiang, Seleeke Flingai, Amir S. Khan, Kar Muthumani, Laurent Humeau, Lily I. Cheng, Leslie Wachter-Rosati, C. Kendall Stover, Niranjan Y. Sardesai, David B. Weiner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases. Here, the authors show that two DMAbs targeting Pseudomonas aeruginosa proteins confer protectio
Externí odkaz:
https://doaj.org/article/5cc6f71f1078455d97d037b4f8457a6b
Autor:
Sarah T. C. Elliott, Nicole L. Kallewaard, Ebony Benjamin, Leslie Wachter-Rosati, Josephine M. McAuliffe, Ami Patel, Trevor R. F. Smith, Katherine Schultheis, Daniel H. Park, Seleeke Flingai, Megan C. Wise, Janess Mendoza, Stephanie Ramos, Kate E. Broderick, Jian Yan, Laurent M. Humeau, Niranjan Y. Sardesai, Kar Muthumani, Qing Zhu, David B. Weiner
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-9 (2017)
Nucleic acid delivery: Instant, wide-ranging protection against influenza A and B A novel innoculation technique involving the injection of antibody-producing plasmid DNA has shown to be effective against influenza in mice. The flu is responsible for
Externí odkaz:
https://doaj.org/article/eacd8d537f1948d3bf6f77c99669bab8
Autor:
Ami Patel, Daniel H. Park, Carl W. Davis, Trevor R.F. Smith, Anders Leung, Kevin Tierney, Aubrey Bryan, Edgar Davidson, Xiaoying Yu, Trina Racine, Charles Reed, Marguerite E. Gorman, Megan C. Wise, Sarah T.C. Elliott, Rianne Esquivel, Jian Yan, Jing Chen, Kar Muthumani, Benjamin J. Doranz, Erica Ollmann Saphire, James E. Crowe, Kate E. Broderick, Gary P. Kobinger, Shihua He, Xiangguo Qiu, Darwyn Kobasa, Laurent Humeau, Niranjan Y. Sardesai, Rafi Ahmed, David B. Weiner
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1982-1993.e4 (2018)
Summary: Synthetically engineered DNA-encoded monoclonal antibodies (DMAbs) are an in vivo platform for evaluation and delivery of human mAb to control against infectious disease. Here, we engineer DMAbs encoding potent anti-Zaire ebolavirus (EBOV) g
Externí odkaz:
https://doaj.org/article/1ccb9ff1c2b54bf9a2b1ef9f65731144
Autor:
Kimberly J. Edwards, Bryan Chang, Hasan Babazada, Katheryn Lohith, Daniel H. Park, Michael D. Farwell, Mark A. Sellmyer
Publikováno v:
Cancer Immunol Res
Immune checkpoint inhibitors (ICI) have been effective in treating a subset of refractory solid tumors, but only a small percentage of treated patients benefit from these therapies. Thus, there is a clinical need for reliable tools that allow for the
Autor:
Mark A. Sellmyer, Michael D. Farwell, Daniel H. Park, Katheryn Lohith, Hasan Babazada, Bryan Chang, Kimberly J. Edwards
Supplementary Data from Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8316233ef03976b13613ed11b61a8e
https://doi.org/10.1158/2326-6066.22545642
https://doi.org/10.1158/2326-6066.22545642