Plasma YKL-40 is associated with prognosis in patients with metastatic pancreatic cancer receiving immune checkpoint inhibitors in combination with radiotherapy

Autor: Astrid Z. Johansen, Sif I. Novitski, Jessica X. Hjaltelin, Susann Theile, Mogens K. Boisen, Søren Brunak, Daniel H. Madsen, Dorte L. Nielsen, Inna M. Chen

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundYKL-40, also known as chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein produced by various cell types including stromal, immune, and cancer cells. It contributes to cancer progression through tumor-promoting inflammation and

Externí odkaz: https://doaj.org/article/17af1821af72431db2979865f0c4c06f

Loss of Ambra1 promotes melanoma growth and invasion

Autor: Luca Di Leo, Valérie Bodemeyer, Francesca M. Bosisio, Giuseppina Claps, Marco Carretta, Salvatore Rizza, Fiorella Faienza, Alex Frias, Shawez Khan, Matteo Bordi, Maria P. Pacheco, Julie Di Martino, Jose J. Bravo-Cordero, Colin J. Daniel, Rosalie C. Sears, Marco Donia, Daniel H. Madsen, Per Guldberg, Giuseppe Filomeni, Thomas Sauter, Caroline Robert, Daniela De Zio, Francesco Cecconi

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.

Externí odkaz: https://doaj.org/article/57c07f6892f24e98b8abf330dfb96699

Collagen density regulates the activity of tumor-infiltrating T cells

Autor: Dorota E. Kuczek, Anne Mette H. Larsen, Marie-Louise Thorseth, Marco Carretta, Adrija Kalvisa, Majken S. Siersbæk, Ana Micaela C. Simões, Anne Roslind, Lars H. Engelholm, Elfriede Noessner, Marco Donia, Inge Marie Svane, Per thor Straten, Lars Grøntved, Daniel H. Madsen

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Background Tumor progression is accompanied by dramatic remodeling of the surrounding extracellular matrix leading to the formation of a tumor-specific ECM, which is often more collagen-rich and of increased stiffness. The altered ECM of the

Externí odkaz: https://doaj.org/article/a8b31eed6af14bd29e66f25eb8528c73

Fibrotic activity quantified in serum by measurements of type III collagen pro-peptides can be used for prognosis across different solid tumor types

Autor: Nicholas Willumsen, Christina Jensen, George Green, Neel I. Nissen, Jaclyn Neely, David M. Nelson, Rasmus S. Pedersen, Peder Frederiksen, Inna M. Chen, Mogens K. Boisen, Astrid Z. Johansen, Daniel H. Madsen, Inge Marie Svane, Allan Lipton, Kim Leitzel, Suhail M. Ali, Janine T. Erler, Daan P. Hurkmans, Ron H. J. Mathijssen, Joachim Aerts, Mohammed Eslam, Jacob George, Claus Christiansen, Mina J. Bissel, Morten A. Karsdal

Publikováno v: Willumsen, N, Jensen, C, Green, G, Nissen, N I, Neely, J, Nelson, D M, Pedersen, R S, Frederiksen, P, Chen, I M, Boisen, M K, Johansen, A Z, Madsen, D H, Svane, I M, Lipton, A, Leitzel, K, Ali, S M, Erler, J T, Hurkmans, D P, Mathijssen, R H J, Aerts, J, Eslam, M, George, J, Christiansen, C, Bissel, M J & Karsdal, M A 2022, ' Fibrotic activity quantified in serum by measurements of type III collagen pro-peptides can be used for prognosis across different solid tumor types ', Cellular and Molecular Life Sciences, vol. 79, no. 4, 204 . https://doi.org/10.1007/s00018-022-04226-0

Due to activation of fibroblast into cancer-associated fibroblasts, there is often an increased deposition of extracellular matrix and fibrillar collagens, e.g. type III collagen, in the tumor microenvironment (TME) that leads to tumor fibrosis (desm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23c51dea2c9709ebdd45cf37da8209a
https://doi.org/10.1007/s00018-022-04226-0

The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1

Autor: Kirstine S. Nørregaard, Henrik J. Jürgensen, Signe Z. Ingvarsen, Signe S. Heltberg, Christina E. Hagensen, Henrik Gårdsvoll, Daniel H. Madsen, Ole N. Jensen, Lars H. Engelholm, Niels Behrendt

Publikováno v: Nørregaard, K S, Jürgensen, H J, Ingvarsen, S Z, Heltberg, S S, Hagensen, C E, Gårdsvoll, H, Madsen, D H, Jensen, O N, Engelholm, L H & Behrendt, N 2022, ' The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1 ', Matrix Biology, vol. 111, pp. 307-328 . https://doi.org/10.1016/j.matbio.2022.07.004

Thrombospondin-1 (TSP-1) is a matricellular protein with a multitude of functions in the pericellular and extracellular environment. We report a novel pathway for the regulation of extracellular TSP-1, governed by the endocytic collagen receptor, uPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baf4316dcc0eec9fc46fb153a90b882
https://pubmed.ncbi.nlm.nih.gov/35878760