Kinetics of imidazole propionate from orally delivered histidine in mice and humans

Autor: Moritz V. Warmbrunn, Ilias Attaye, Anthony Horak, Rakhee Banerjee, William J. Massey, Venkateshwari Varadharajan, Elena Rampanelli, Youling Hao, Sumita Dutta, Ina Nemet, Judith Aron-Wisnewsky, Karine Clément, Annefleur Koopen, Koen Wortelboer, Per-Olof Bergh, Mark Davids, Nadia Mohamed, E. Marleen Kemper, Stanley Hazen, Albert K. Groen, Daniel H. van Raalte, Hilde Herrema, Fredrik Backhed, J. Mark Brown, Max Nieuwdorp

Publikováno v: npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-12 (2024)

Abstract Imidazole Propionate (ImP), a gut-derived metabolite from histidine, affects insulin signaling in mice and is elevated in type 2 diabetes (T2D). However, the source of histidine and the role of the gut microbiota remain unclear. We conducted

Externí odkaz: https://doaj.org/article/b22e925908314b35a5586a8bd491bf29

Oral histidine affects gut microbiota and MAIT cells improving glycemic control in type 2 diabetes patients

Autor: Moritz V. Warmbrunn, Ilias Attaye, Judith Aron-Wisnewsky, Elena Rampanelli, Eduard W.J. van der Vossen, Youling Hao, Annefleur Koopen, Per-Olof Bergh, Daniela Stols-Gonçalves, Nadia Mohamed, Marleen Kemper, Xanthe Verdoes, Koen Wortelboer, Mark Davids, Eugeni Belda, Sébastien André, Stanley Hazen, Karine Clement, Bert Groen, Daniel H. van Raalte, Hilde Herrema, Fredrik Backhed, Max Nieuwdorp

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

Amino acids, metabolized by host cells as well as commensal gut bacteria, have signaling effects on host metabolism. Oral supplementation of the essential amino acid histidine has been shown to exert metabolic benefits. To investigate whether dietary

Externí odkaz: https://doaj.org/article/b848827631a747d88b5b747a6c0931c9

Effects of dapagliflozin on volume status and systemic haemodynamics in patients with chronic kidney disease without diabetes

Autor: Taha Sen, Rosalie Scholtes, Peter J. Greasley, David Z. I. Cherney, Claire C. J. Dekkers, Marc Vervloet, Alexander H. J. Danser, Sean J. Barbour, Cecilia Karlsson, Ann Hammarstedt, Qiang Li, Gozewijn D. Laverman, Petter Bjornstad, Daniel H. van Raalte, Hiddo J. L. Heerspink

Publikováno v: Diabetes, Obesity and Metabolism
Sen, T, Scholtes, R, Greasley, P J, Cherney, D Z I, Dekkers, C C J, Vervloet, M, Danser, A H J, Barbour, S J, Karlsson, C, Hammarstedt, A, Li, Q, Laverman, G D, Bjornstad, P, van Raalte, D H & Heerspink, H J L 2022, ' Effects of dapagliflozin on volume status and systemic haemodynamics in patients with chronic kidney disease without diabetes : Results from DAPASALT and DIAMOND ', Diabetes, Obesity and Metabolism, vol. 24, no. 8, pp. 1578-1587 . https://doi.org/10.1111/dom.14729
Diabetes, Obesity and Metabolism, 24(8), 1578-1587. Wiley-Blackwell Publishing Ltd
Diabetes obesity & metabolism, 24(8), 1578-1587. Wiley
Diabetes, Obesity and Metabolism, 24(8), 1578-1587. Wiley-Blackwell

Aims: To assess the effect of sodium-glucose cotransporter-2 inhibitor dapagliflozin on natriuresis, blood pressure (BP) and volume status in patients with chronic kidney disease (CKD) without diabetes. Materials and methods: We performed a mechanist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301f73cf8bf57b4d6c11dea43f3b3dc5
https://doi.org/10.1111/dom.14729

Exposure–Response Analysis of the Sodium–Glucose Cotransporter-2 Inhibitors Dapagliflozin and Empagliflozin on Kidney Hemodynamics in Patients with Type 2 Diabetes

Autor: Sjoukje van der Hoek, Jeroen V. Koomen, Erik J. M. van Bommel, Charlotte M. Mosterd, Rosalie A. Scholtes, Anne C. Hesp, Jasper Stevens, Daniel H. van Raalte, Hiddo J. L. Heerspink

Publikováno v: van der Hoek, S, Koomen, J V, van Bommel, E J M, Mosterd, C M, Scholtes, R A, Hesp, A C, Stevens, J, van Raalte, D H & Heerspink, H J L 2023, ' Exposure–Response Analysis of the Sodium–Glucose Cotransporter-2 Inhibitors Dapagliflozin and Empagliflozin on Kidney Hemodynamics in Patients with Type 2 Diabetes ', Journal of personalized medicine, vol. 13, no. 5, 747 . https://doi.org/10.3390/jpm13050747
Journal of personalized medicine, 13(5):747. MDPI AG
Journal of Personalized Medicine; Volume 13; Issue 5; Pages: 747
Journal of personalized medicine, 13(5):747. Multidisciplinary Digital Publishing Institute (MDPI)

Sodium–glucose cotransporter-2 (SGLT2) inhibitors improve markers for renal and cardiovascular outcomes in patients with and without type 2 diabetes (T2D). To assess whether individual differences in plasma drug exposure can explain inter-individua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cc313ccc91b0131f6f4169819d073b
https://research.vumc.nl/en/publications/8d520102-a9a8-479e-9f69-9203331b9919

Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes

Autor: Timothy Vigers, Carissa Vinovskis, Lu-Ping Li, Pottumarthi Prasad, Hiddo Heerspink, Angelo D’Alessandro, Julie A. Reisz, Federica Piani, David Z. Cherney, Daniel H. van Raalte, Kristen J. Nadeau, Meda E. Pavkov, Robert G. Nelson, Laura Pyle, Petter Bjornstad

Publikováno v: Vigers, T, Vinovskis, C, Li, L-P, Prasad, P, Heerspink, H, D’Alessandro, A, Reisz, J A, Piani, F, Cherney, D Z, van Raalte, D H, Nadeau, K J, Pavkov, M E, Nelson, R G, Pyle, L & Bjornstad, P 2023, ' Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes ', Pediatric Nephrology, vol. 38, no. 1, pp. 193-202 . https://doi.org/10.1007/s00467-022-05531-3
Pediatric Nephrology, 38. SPRINGER
Pediatric Nephrology, 38(1), 193-202. Springer Verlag

Background: We compared plasma metabolites of amino acid oxidation and the tricarboxylic acid (TCA) cycle in youth with and without type 1 diabetes mellitus (T1DM) and related the metabolites to glomerular filtration rate (GFR), renal plasma flow (RP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f64441c6269542e469b6539689fb786
https://research.vumc.nl/en/publications/dd22b9e2-67a4-41b9-97fe-b73c9137010a