Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daniel H Paushter"'
Autor:
Xiaolai Zhou, Daniel H Paushter, Mitchell D Pagan, Dongsung Kim, Mariela Nunez Santos, Raquel L Lieberman, Herman S Overkleeft, Ying Sun, Marcus B Smolka, Fenghua Hu
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0212382 (2019)
Mutation in the GRN gene, encoding the progranulin (PGRN) protein, shows a dose-dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar degeneration (FTLD) and complete loss results in neuronal ceroid lipofuscinosis
Externí odkaz:
https://doaj.org/article/f702a5e6783641b88e7bf48fd81d95ed
Autor:
Peter M. Sullivan, Tuancheng Feng, Isabel Iscol Katz, Rory R Sheng, Daniel H. Paushter, Santiago Solé-Domènech, Fenghua Hu, Frederick R. Maxfield, Mohammed Ullah, Xiaochun Wu, Christina S. Mendoza, Laura Camila Martinez Enriquez, Xiaolai Zhou
Publikováno v:
Brain
TMEM106B encodes a lysosomal membrane protein and was initially identified as a risk factor for frontotemporal lobar degeneration. Recently, a dominant D252N mutation in TMEM106B was shown to cause hypomyelinating leukodystrophy. However, how TMEM106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce1776de72ec84aac9e04683d5aca86
https://doi.org/10.1093/brain/awaa154
https://doi.org/10.1093/brain/awaa154
Autor:
Mariela Nunez Santos, Daniel H. Paushter, Tingting Zhang, Xiaochun Wu, Tuancheng Feng, Jiaoying Lou, Huan Du, Stephanie M. Becker, Robert Fragoza, Haiyuan Yu, Fenghua Hu
Publikováno v:
Journal of Biological Chemistry. 298:102348
Progranulin (PGRN) is a glycoprotein implicated in several neurodegenerative diseases. It is highly expressed in microglia and macrophages and can be secreted or delivered to the lysosome compartment. PGRN comprises 7.5 granulin repeats and is proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2829cd5247c33743e34d102fc4d977ea
https://doi.org/10.1016/j.jbc.2022.102348
https://doi.org/10.1016/j.jbc.2022.102348
Autor:
Daniel H. Paushter, Meirigeng Qi, Kirstie K. Danielson, Tricia A. Harvat, Katie Kinzer, Barbara Barbaro, Sonny Patel, Sarah Z. Hassan, Jose Oberholzer, Yong Wang
Publikováno v:
Cell Transplantation, Vol 22 (2013)
We previously reported a small-scale study on the efficacy of histidine-tryptophan-ketoglutarate (HTK) solution versus University of Wisconsin (UW) solution on pancreas preservation for islet isolation. In this large-scale, retrospective analysis ( n
Externí odkaz:
https://doaj.org/article/bbf422f6ffd4453cbb722721bddb5eb9
Autor:
Fenghua Hu, Marcus B. Smolka, Ying Sun, Herman S. Overkleeft, Raquel L. Lieberman, Dongsung Kim, Daniel H. Paushter, Mitchell D. Pagan, Xiaolai Zhou
Mutation in theGRNgene, encoding the progranulin (PGRN) protein, shows a dose-dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar degeneration (FTLD) and complete loss results in neuronal ceroid lipofuscinosis (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec08fc097dbdd5ccb166b394cf22c70
https://doi.org/10.1101/540450
https://doi.org/10.1101/540450
Autor:
Tuancheng Feng, Xiaolai Zhou, Christina S. Mendoza, Cara M. Pardon, Daniel H. Paushter, Fenghua Hu
Publikováno v:
Acta Neuropathologica. 134:151-153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570560a76ad1bbbd4dbaf3827e6a8598
https://doi.org/10.1007/s00401-017-1719-5
https://doi.org/10.1007/s00401-017-1719-5
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1806
Accumulating evidence suggests that progranulin is essential for proper lysosomal function. Progranulin is a lysosomal resident protein and sortilin has been demonstrated to be the lysosomal trafficking receptor for progranulin. Here we describe the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9d1800e7a848d9a36a9b70288b17bfc
https://pubmed.ncbi.nlm.nih.gov/29956282
https://pubmed.ncbi.nlm.nih.gov/29956282
Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor implicated in a multitude of processes ranging from regulation of inflammation to wound healing and tumorigenesis. The clinical importance of PGRN became especially ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d9ca123cef6cb82dd3dcf139865e98
https://europepmc.org/articles/PMC6117207/
https://europepmc.org/articles/PMC6117207/
Publikováno v:
Methods in Molecular Biology ISBN: 9781493985579
Accumulating evidence suggests that progranulin is essential for proper lysosomal function. Progranulin is a lysosomal resident protein and sortilin has been demonstrated to be the lysosomal trafficking receptor for progranulin. Here we describe the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0106e8b43004e1bb4a1793e9e4102999
https://doi.org/10.1007/978-1-4939-8559-3_18
https://doi.org/10.1007/978-1-4939-8559-3_18
Publikováno v:
Molecular Neurodegeneration
Background Mutations resulting in progranulin (PGRN) haploinsufficiency cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. PGRN is localized to the lysosome and important for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d744e9b6a5fad4abea96de599b12b441
https://doi.org/10.1186/s13024-017-0205-9
https://doi.org/10.1186/s13024-017-0205-9