Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daniel H O' Donovan"'
Publikováno v:
Journal of Medicinal Chemistry. 66:2347-2360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5187c5a14590000a68da6dc4688de74e
https://doi.org/10.1021/acs.jmedchem.2c01577
https://doi.org/10.1021/acs.jmedchem.2c01577
Autor:
David Longmire, Haley Woods, Phillip B Rawlins, Jessie Hao-Ru Hsu, Daniel H O' Donovan, Alexandra Borodovsky, Peng Wang, Sharan K Bagal, Shaun M Fillery, Peter Barton, Clare Gregson, Beth Williamson, Samuel C Nash, Andrew Pike, Jon A Read, Kurt Gordon Pike, Andrew Bloecher, Erin Code, Minhui Shen, Sameer Kawatkar, Youfeng Nai, Jia Tang, Chengzhi Li, James C. Robinson
Publikováno v:
Journal of Medicinal Chemistry. 64:17146-17183
Aberrant activity of the histone methyltransferase polycomb repressive complex 2 (PRC2) has been linked to several cancers, with small-molecule inhibitors of the catalytic subunit of the PRC2 enhancer of zeste homologue 2 (EZH2) being recently approv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbef686d9310c0393124b8f8df7ca38
https://doi.org/10.1021/acs.jmedchem.1c01161
https://doi.org/10.1021/acs.jmedchem.1c01161
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:119-135
PRC2 is a histone methyltransferase complex associated with several cancer types. Tazemetostat was recently approved as the first inhibitor targeting the catalytic subunit EZH2 and several other EZH2 inhibitors are now under clinical evaluation. Beyo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1496a9d48dda47419e6ed10dacb321c2
https://doi.org/10.1080/13543776.2021.1841167
https://doi.org/10.1080/13543776.2021.1841167
Publikováno v:
Chemical Society reviews. 50(3)
Peptides can offer the versatility needed for a successful oncology drug discovery approach. Peptide-drug conjugates (PDCs) are an emerging targeted therapeutic that present increased tumour penetration and selectivity. Despite these advantages, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a0a3812edb0e2f84bb80b156526a04
https://pubmed.ncbi.nlm.nih.gov/33346298
https://pubmed.ncbi.nlm.nih.gov/33346298
Autor:
Paul Aillard, Aurélien de la Torre, Marcel Kaiser, Nuno Maulide, Daniel H. O' Donovan, Christian Knittl-Frank, Martin Berger, Desislava Petkova, Danny Geerdink
Publikováno v:
Angewandte Chemie. 130:10897-10901
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f74fbe56015a338b62ff3c2dd7f6f53
https://doi.org/10.1002/ange.201804551
https://doi.org/10.1002/ange.201804551
Autor:
J. Iegre, Daniel H. O' Donovan, Hannah F. Sore, Chandra S. Verma, Yaw Sing Tan, Eleanor L Atkinson, David Baker, Marko Hyvönen, David R. Spring, Paul Brear
Publikováno v:
Chemical Science
This work describes the efficient development of functionalised, cell-permeable, and stable peptide inhibitors of the protein–protein interaction of CK2.
The discovery of new Protein–Protein Interaction (PPI) modulators is currently limited
The discovery of new Protein–Protein Interaction (PPI) modulators is currently limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66338219fd9123ba3f01a25a69706f2
https://www.repository.cam.ac.uk/handle/1810/292034
https://www.repository.cam.ac.uk/handle/1810/292034
Publikováno v:
Current medicinal chemistry. 27(34)
The recent success of checkpoint blocking antibodies has sparked a revolution in cancer immunotherapy. Checkpoint inhibition activates the adaptive immune system leading to durable responses across a range of tumor types, although this response is li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4babd54443252b8e2cc0a68053a0187f
https://pubmed.ncbi.nlm.nih.gov/31250749
https://pubmed.ncbi.nlm.nih.gov/31250749
Autor:
Sameer Kawatkar, Philip B. Rawlins, Kurt Gordon Pike, Jessie Hao-Ru Hsu, Shaun M. Fillery, Clare Gregson, Minhui Shen, Daniel H. O' Donovan, Martin J. Packer, Jon Read, S. Bagal, Andrew Bloecher, Beth Williamson, James Robinson, Peter Barton, Ryan Greenwood, Erin Code, Haley Woods
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 39:127904
Free Energy Perturbation (FEP) calculations can provide high-confidence predictions of the interaction strength between a ligand and its protein target. We sought to explore a series of triazolopyrimidines which bind to the EED subunit of the PRC2 co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19eb341b997e66a555f392e58836843
https://doi.org/10.1016/j.bmcl.2021.127904
https://doi.org/10.1016/j.bmcl.2021.127904
Autor:
Sameer Kawatkar, Philip B. Rawlins, Ning Gao, S. Bagal, Ronald Tomlinson, David Matthew Wilson, Elisabetta Chiarparin, James Robinson, Jessie Hao-Ru Hsu, Erin Code, Emma Bednarski, Lisa Drew, Kelly Jacques, Stephen Fawell, Andrew Bloecher, Xiahui Zhu, M. Paola Castaldi, Timothy Rasmusson, Haley Woods, Jon Read, Argyrides Argyrou, Minhui Shen, Daniel H. O' Donovan, Fiona Pachl
Publikováno v:
Cell Chemical Biology. 27:41-46.e17
Summary Deregulation of the PRC2 complex, comprised of the core subunits EZH2, SUZ12, and EED, drives aberrant hypermethylation of H3K27 and tumorigenicity of many cancers. Although inhibitors of EZH2 have shown promising clinical activity, preclinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eff7ece91c5973a337e9c595e228677
https://doi.org/10.1016/j.chembiol.2019.11.004
https://doi.org/10.1016/j.chembiol.2019.11.004
Autor:
Daniel H. O' Donovan, Kara Herlihy, Maria E. Lopes-Pires, Nicholas Pugh, Yu Heng Lau, Rupam Jha, Niaz S. Ahmed, Chandra S. Verma, Yuteng Wu, Yaw Sing Tan, J. Iegre, Josephine Gaynord, David R. Spring, Hannah F. Sore
Publikováno v:
Chemical Science
We describe the first application of stapled peptides in human platelets. Bim BH3 stapled peptides are used to overcome the limitations of traditional methods and uncover a new role for Bim in platelet activation.
Platelets are blood cells with
Platelets are blood cells with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba783c8f492db20607091cdd22e928c
https://hdl.handle.net/10356/87585
https://hdl.handle.net/10356/87585