Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Daniel H Kaplan"'
Autor:
Emilie V Russler-Germain, Jaeu Yi, Shannon Young, Katherine Nutsch, Harikesh S Wong, Teresa L Ai, Jiani N Chai, Vivek Durai, Daniel H Kaplan, Ronald N Germain, Kenneth M Murphy, Chyi-Song Hsieh
Publikováno v:
eLife, Vol 10 (2021)
Generation of tolerogenic peripheral regulatory T (pTreg) cells is commonly thought to involve CD103+ gut dendritic cells (DCs), yet their role in commensal-reactive pTreg development is unclear. Using two Helicobacter-specific T cell receptor (TCR)
Externí odkaz:
https://doaj.org/article/007c449ec2de46e180b76c8533b9af29
Autor:
David S Nelson, Ryan L Marano, Yechaan Joo, Sara Y Tian, Bhumi Patel, Daniel H Kaplan, Mark J Shlomchik, Kristen Stevenson, Roderick T Bronson, Barrett J Rollins
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222400 (2019)
Langerhans cell histiocytosis (LCH) is characterized by the accumulation of Langerin (CD207)-expressing histiocytes. Mutational activation of mitogen-activated protein kinase pathway genes, in particular BRAF, drives most cases. To test whether activ
Externí odkaz:
https://doaj.org/article/558463d275d0429ebb07e2d707219cea
Publikováno v:
eLife, Vol 5 (2016)
Strong antibody response is considered a hallmark of a successful vaccine. While dendritic cells (DCs) are important for T follicular helper (Tfh) cell priming, how this process is regulated in vivo is unclear. We show here that the depletion of CD30
Externí odkaz:
https://doaj.org/article/db3f705b0cc9428a8b5e9537dde839c9
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84019 (2014)
Barrier surfaces, such as the intestinal lining and the skin, are colonized by a diverse community of commensal microorganisms. Although commensal microorganisms clearly impact the host immune system, whether the immune system also shapes the commens
Externí odkaz:
https://doaj.org/article/d9ed14a0299a4fecaa441212c594d298
Publikováno v:
Journal of Allergy and Clinical Immunology. 151:1169-1177
Publikováno v:
Journal of Investigative Dermatology. 142:841-848
Skin-resident mast cells (MCs) and cutaneous sensory neurons both play crucial roles in microbial‒host defense and inflammatory diseases. MCs can be directly activated by pathogens or their products, resulting in the release of numerous mediators t
Autor:
Sarah K. Whitley, Mushi Li, Sakeen W. Kashem, Toshiro Hirai, Botond Z. Igyártó, Kelley Knizner, Jonhan Ho, Laura K. Ferris, Casey T. Weaver, Daniel J. Cua, Mandy J. McGeachy, Daniel H. Kaplan
Publikováno v:
Science Immunology. 7
The cytokine interleukin-23 (IL-23) is critical for development and maintenance of autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which IL-23 supports tissue-specific immunity remains unclear. In mice, we found that ci
Autor:
Jonathan A. Cohen, Daniel H. Kaplan
Publikováno v:
Immunity. 55:11-13
Autor:
Arun L. Pathy, Kenneth B. Gordon, Mark Lebwohl, Daniel H. Kaplan, Arthur Kavanaugh, Michael Siegel, Henry W. Lim, Dawn Marie R. Davis, Amy S. Paller, Nehal N. Mehta, Craig A. Elmets, Alan Menter, April W. Armstrong, Alice B. Gottlieb, Joel M. Gelfand, Kelly M. Cordoro, Emily B. Wong, Reena N. Rupani, Jason Lichten, Elizabeth Farley Prater, Craig L. Leonardi, Dario Kivelevitch, Cody Connor, Boni E. Elewski, Sylvia L. Parra, Bruce Strober, Benjamin K. Stoff, Jashin J. Wu, Matthew Kiselica, Neil J. Korman, Daniela Kroshinsky, Vidhya Hariharan
Publikováno v:
Journal of the American Academy of Dermatology. 84:432-470
Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the United States population. This guideline addresses important clinical questions that arise in psoriasis management and care and provides recommendations based on
Autor:
Dario Kivelevitch, Jason Lichten, April W. Armstrong, Robert S. Rahimi, Emily B. Wong, Reena N. Rupani, Nehal N. Mehta, Alan Menter, Neil J. Korman, Craig A. Elmets, Amy S. Paller, Arun L. Pathy, Craig L. Leonardi, Arthur Kavanaugh, Boni E. Elewski, Matthew Kiselica, Daniel H. Kaplan, Sylvia L. Parra, Michael Siegel, Benjamin K. Stoff, Dawn Marie R. Davis, Mark Lebwohl, Kenneth B. Gordon, Alice B. Gottlieb, Cody Connor, Jashin J. Wu, Bruce Strober, Kelly M. Cordoro, Elizabeth Farley Prater, Elliot B. Tapper, Vidhya Hariharan, Henry W. Lim, Daniela Kroshinsky, Joel M. Gelfand
Publikováno v:
Journal of the American Academy of Dermatology. 82:1445-1486
Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 2% of the world's population. In this guideline, we focus the discussion on systemic, nonbiologic medications for the treatment of this disease.