Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Daniel H Goldhill"'
Autor:
Daniel H Goldhill, Ada Yan, Rebecca Frise, Jie Zhou, Jennifer Shelley, Ana Gallego Cortés, Shahjahan Miah, Omolola Akinbami, Monica Galiano, Maria Zambon, Angie Lackenby, Wendy S Barclay
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1008937 (2021)
Favipiravir is a nucleoside analogue which has been licensed to treat influenza in the event of a new pandemic. We previously described a favipiravir resistant influenza A virus generated by in vitro passage in presence of drug with two mutations: K2
Externí odkaz:
https://doaj.org/article/ff4ebd2f5f6f4ee69ced766d193671f8
Autor:
Claire Scott, Jayakanth Kankanala, Toshana L Foster, Daniel H Goldhill, Peng Bao, Katie Simmons, Marieke Pingen, Matthew Bentham, Elizabeth Atkins, Eleni Loundras, Ruth Elderfield, Jolyon K Claridge, Joseph Thompson, Peter R Stilwell, Ranjitha Tathineni, Clive S McKimmie, Paul Targett-Adams, Jason R Schnell, Graham P Cook, Stephen Evans, Wendy S Barclay, Richard Foster, Stephen Griffin
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008716 (2020)
Pandemic influenza A virus (IAV) remains a significant threat to global health. Preparedness relies primarily upon a single class of neuraminidase (NA) targeted antivirals, against which resistance is steadily growing. The M2 proton channel is an alt
Externí odkaz:
https://doaj.org/article/b1c9af88e0784e2fbf40273c4f74c8fe
Autor:
Leo Yi Yang Lee, Jie Zhou, Rebecca Frise, Daniel H Goldhill, Paulina Koszalka, Edin J Mifsud, Kaoru Baba, Takahiro Noda, Yoshinori Ando, Kenji Sato, Aoe-Ishikawa Yuki, Takao Shishido, Takeki Uehara, Steffen Wildum, Elke Zwanziger, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Aeron C Hurt, Wendy S Barclay
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008395 (2020)
Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat. Although vaccines are available for influenza control, their efficacy varies each season and a vaccine for a novel pandemic virus manufactured using current technology
Externí odkaz:
https://doaj.org/article/61b97708882143f882083c1fe0a052d6
Autor:
Carol M. Sheppard, Daniel H. Goldhill, Olivia C. Swann, Ecco Staller, Rebecca Penn, Olivia K. Platt, Ksenia Sukhova, Laury Baillon, Rebecca Frise, Thomas P. Peacock, Ervin Fodor, Wendy S. Barclay
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Human ANP32A and ANP32B are essential but redundant host factors for influenza virus genome replication. While most influenza viruses cannot replicate in edited human cells lacking both ANP32A and ANP32B, some strains exhibit limited growth.
Externí odkaz:
https://doaj.org/article/9ea86ca4471f48e0947e131249f06d09
Autor:
Alewo Idoko-Akoh, Daniel H. Goldhill, Carol M. Sheppard, Dagmara Bialy, Jessica L. Quantrill, Ksenia Sukhova, Jonathan C. Brown, Samuel Richardson, Ciara Campbell, Lorna Taylor, Adrian Sherman, Salik Nazki, Jason S. Long, Michael A. Skinner, Holly Shelton, Helen M. Sang, Wendy S. Barclay, Mike J. McGrew
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chickens genetically resistant to avian influenza could prevent future outbreaks. In chickens, influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to generate homozygous gene edited (GE) chickens containing two ANP
Externí odkaz:
https://doaj.org/article/7998dd1a4f034f389765c3544b67d16a
Levels of Influenza A Virus Defective Viral Genomes Determine Pathogenesis in the BALB/c Mouse Model
Autor:
Rebecca Penn, John S. Tregoning, Katie E. Flight, Laury Baillon, Rebecca Frise, Daniel H. Goldhill, Cecilia Johansson, Wendy S. Barclay
Publikováno v:
Journal of Virology. 96
Defective viral genomes (DVGs), which are generated by the viral polymerase in error during RNA replication, can trigger innate immunity and are implicated in altering the clinical outcome of infection. Here, we investigated the impact of DVGs on inn
Autor:
Daniel H. Goldhill, Wendy S. Barclay
Publikováno v:
Evolution; International Journal of Organic Evolution
Autor:
Laury Baillon, Rebecca Frise, Jack A. Hassard, Thomas P. Peacock, Mauro Giacca, Brian Hanley, Wendy S. Barclay, Jonathan Brown, Olivia C. Swann, Raul Y. Sanchez-David, David A. Matthews, Rebecca Penn, Luca Braga, Michael Osborn, Ruthiran Kugathasan, Ecco Staller, Andrew D. Davidson, Maia Kavanagh Williamson, Jie Zhou, Daniel H. Goldhill
Publikováno v:
Peacock, T P, Kavanagh Williamson, M, Davidson, A D, Matthews, D A, Barclay, W S & al., E 2021, ' The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets ', Nature Microbiology, vol. 6, no. 7, pp. 899-909 . https://doi.org/10.1038/s41564-021-00908-w
SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2' cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (PRRAR) at the S1/S2 cleavage site that can be cleaved by furin. Using le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e0ee5684faaff04732d4036d11db63
http://hdl.handle.net/10044/1/98544
http://hdl.handle.net/10044/1/98544
Autor:
Paul F. McKay, Maya Moshe, Jonathan C Brown, Thomas Burgoyne, Thomas P. Peacock, Jie Zhou, Andreia Lucia Pinto, Wendy S. Barclay, Ruthiran Kugathasan, Daniel H. Goldhill, Jack A. Hassard, Niluka Goonawardane, Aran Singanayagam, Laury Baillon, Rebecca Frise
Lineage B.1.1.7 (Variant of Concern 202012/01) is a new SARS-CoV-2 variant which was first sequenced in the UK in September 2020 before becoming the majority strain in the UK and spreading worldwide. The rapid spread of the B.1.1.7 variant results fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a28834676a95b52e2bdedd776eda666
https://doi.org/10.1101/2021.02.24.432576
https://doi.org/10.1101/2021.02.24.432576
Autor:
Hashim Ali, Ilaria Secco, Daniel H. Goldhill, Jose M. Jimenez-Guardeño, Luca Braga, Juan Burrone, Giorgia Rizzari, Guilherme Neves, Antonio Cannatà, Edoardo Schneider, Chiara Collesi, Mauro Giacca, Ajay M. Shah, Michael H. Malim, Rebecca Penn, Wendy S. Barclay, Elena Chiavacci, Daniele Arosio, Rossana Bussani, Ana Maria Ortega-Prieto
Publikováno v:
Nature
Nature (Lond.) 594 (2021): 88–93. doi:10.1038/s41586-021-03491-6
info:cnr-pdr/source/autori:Braga L.; Ali H.; Secco I.; Chiavacci E.; Neves G.; Goldhill D.; Penn R.; Jimenez-Guardeno J.M.; Ortega-Prieto A.M.; Bussani R.; Cannata A.; Rizzari G.; Collesi C.; Schneider E.; Arosio D.; Shah A.M.; Barclay W.S.; Malim M.H.; Burrone J.; Giacca M./titolo:Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia/doi:10.1038%2Fs41586-021-03491-6/rivista:Nature (Lond.)/anno:2021/pagina_da:88/pagina_a:93/intervallo_pagine:88–93/volume:594
Nature (Lond.) 594 (2021): 88–93. doi:10.1038/s41586-021-03491-6
info:cnr-pdr/source/autori:Braga L.; Ali H.; Secco I.; Chiavacci E.; Neves G.; Goldhill D.; Penn R.; Jimenez-Guardeno J.M.; Ortega-Prieto A.M.; Bussani R.; Cannata A.; Rizzari G.; Collesi C.; Schneider E.; Arosio D.; Shah A.M.; Barclay W.S.; Malim M.H.; Burrone J.; Giacca M./titolo:Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia/doi:10.1038%2Fs41586-021-03491-6/rivista:Nature (Lond.)/anno:2021/pagina_da:88/pagina_a:93/intervallo_pagine:88–93/volume:594
COVID-19 is a disease with unique characteristics that include lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar oedema4. The pathological substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee8ef2a9edf1c3b1df8e8a7186d90cf
http://hdl.handle.net/11368/2993737
http://hdl.handle.net/11368/2993737