Výsledky vyhledávání - "Daniel H Fowler"

Akademický článek

Autologous, lentivirus‐modified, T‐rapa cell 'micropharmacies' for lysosomal storage disorders

Autor: Murtaza S Nagree, Tania C Felizardo, Mary L Faber, Jitka Rybova, C Anthony Rupar, S Ronan Foley, Maria Fuller, Daniel H Fowler, Jeffrey A Medin

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-13 (2022)

Abstract T cells are the current choice for many cell therapy applications. They are relatively easy to access, expand in culture, and genetically modify. Rapamycin‐conditioning ex vivo reprograms T cells, increasing their memory properties and cap

Externí odkaz: https://doaj.org/article/0079c95dea544963be14b09273e298e6

Zobrazit plný text záznamu

Akademický článek

Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity.

Autor: Courtney W Mangus, Paul R Massey, Daniel H Fowler, Shoba Amarnath

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72305 (2013)

The cytokine micro-environment can direct murine CD4(+) T cells towards various differentiation lineages such as Th1, Th2 and Tregs even in the presence of rapamycin, which results in T cells that mediate increased in vivo effects. Recently, a new li

Externí odkaz: https://doaj.org/article/c8312c52082d4f7497f31956e79dfbc2

Zobrazit plný text záznamu

Akademický článek

Host-based Th2 cell therapy for prolongation of cardiac allograft viability.

Autor: Shoba Amarnath, Hao Chen, Jason E Foley, Carliann M Costanzo, Joel D Sennesh, Michael A Solomon, Daniel H Fowler

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18885 (2011)

Donor T cell transfusion, which is a long-standing approach to prevent allograft rejection, operates indirectly by alteration of host T cell immunity. We therefore hypothesized that adoptive transfer of immune regulatory host Th2 cells would represen

Externí odkaz: https://doaj.org/article/e854f37823df4609ad897ed689ba5056

Zobrazit plný text záznamu

Akademický článek

Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

Autor: Shoba Amarnath, Carliann M Costanzo, Jacopo Mariotti, Jessica L Ullman, William G Telford, Veena Kapoor, James L Riley, Bruce L Levine, Carl H June, Timothy Fong, Noel L Warner, Daniel H Fowler

Publikováno v: PLoS Biology, Vol 8, Iss 2, p e1000302 (2010)

Immunotherapy using regulatory T cells (Treg) has been proposed, yet cellular and molecular mechanisms of human Tregs remain incompletely characterized. Here, we demonstrate that human Tregs promote the generation of myeloid dendritic cells (DC) with

Externí odkaz: https://doaj.org/article/51447135cf054e8d9db8f38373ff2954

Zobrazit plný text záznamu

Akademický článek

A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.

Autor: Courtney A Granville, Regan M Memmott, Andria Balogh, Jacopo Mariotti, Shigeru Kawabata, Wei Han, Jaclyn Lopiccolo, Jason Foley, David J Liewehr, Seth M Steinberg, Daniel H Fowler, M Christine Hollander, Phillip A Dennis

Publikováno v: PLoS ONE, Vol 4, Iss 3, p e5061 (2009)

K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarc

Externí odkaz: https://doaj.org/article/8db6ea945f494ba598f5f20f7720f5e3

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání