Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Daniel H Arlow"'
Autor:
Joshua M Baughman, Roland Nilsson, Vishal M Gohil, Daniel H Arlow, Zareen Gauhar, Vamsi K Mootha
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000590 (2009)
The human oxidative phosphorylation (OxPhos) system consists of approximately 90 proteins encoded by nuclear and mitochondrial genomes and serves as the primary cellular pathway for ATP biosynthesis. While the core protein machinery for OxPhos is wel
Externí odkaz:
https://doaj.org/article/566fc7fd4a704dcd84fd1699d929f3a1
Autor:
Jake A. Smith, Bichlien H. Nguyen, Rob Carlson, Jeffrey G. Bertram, Sebastian Palluk, Daniel H. Arlow, Karin Strauss
Publikováno v:
ACS Synthetic Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6db8ef7b12e09842a92b112c63cbc6ad
https://doi.org/10.1021/acssynbio.3c00044
https://doi.org/10.1021/acssynbio.3c00044
Publikováno v:
Genes, Vol 11, Iss 1, p 102 (2020)
Genes, vol 11, iss 1
Genes
Genes, vol 11, iss 1
Genes
Enzymatic oligonucleotide synthesis methods based on the template-independent polymerase terminal deoxynucleotidyl transferase (TdT) promise to enable the de novo synthesis of long oligonucleotides under mild, aqueous conditions. Intermediates with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda6a576ab79f0080f484960493f328e
Autor:
Daniel H. Arlow, Zhongyu Yang, Aashish Manglik, David W. Borhani, Ansgar Philippsen, Thomas J. Mildorf, Michael T. Lerch, Brian K. Kobilka, Daniel Hilger, Wayne L. Hubbell, Roger K. Sunahara, Ron O. Dror, David E. Shaw, Nicolas Villanueva
Publikováno v:
Science. 348:1361-1365
How a receptor transmits a signal G protein–coupled receptors (GPCRs) transmit diverse external signals into the cell. When activated by an outside stimulus, they bind to a G protein inside the cell and accelerate exchange of a bound guanosine diph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7852d194960b30cbaad9f4b830f27dbe
https://doi.org/10.1126/science.aaa5264
https://doi.org/10.1126/science.aaa5264
Autor:
Anup K. Singh, Justine S Kang, Tristan de Rond, Peter W. Kim, Alisa N Truong, Hratch M. Baghdassarian, Nathan J. Hillson, Sebastian Barthel, Daniel H. Arlow, Sebastian Palluk, Rathin Bector, Jay D. Keasling
Publikováno v:
Nature biotechnology. 36(7)
Oligonucleotides are almost exclusively synthesized using the nucleoside phosphoramidite method, even though it is limited to the direct synthesis of ∼200 mers and produces hazardous waste. Here, we describe an oligonucleotide synthesis strategy th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27999dd386c0dbe362b26dbefb27478f
https://pubmed.ncbi.nlm.nih.gov/30804572
https://pubmed.ncbi.nlm.nih.gov/30804572
Autor:
Albert C. Pan, Celine Valant, Arthur Christopoulos, James R. Valcourt, Hillary F. Green, Raphaël Rahmani, Patrick M. Sexton, David E. Shaw, Jonathan B. Baell, Daniel H. Arlow, Meritxell Canals, Ron O. Dror, David W. Borhani, J. Robert Lane
Publikováno v:
Nature. 503:295-299
Binding modes and molecular mechanisms of several allosteric modulators of a prototypical G-protein-coupled receptor are revealed using atomic-level simulations and validated by the rational design of a modulator with substantially altered effects. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055fef834dac3bd1044dcc90354af25d
https://doi.org/10.1038/nature12595
https://doi.org/10.1038/nature12595
Autor:
Juan Jose Fung, Albert C. Pan, R. Scott Prosser, Yaozhong Zou, Corey W. Liu, Aashish Manglik, Tong Sun Kobilka, Michael P. Bokoch, Brian K. Kobilka, Rie Nygaard, David E. Shaw, Daniel H. Arlow, Foon Sun Thian, Ron O. Dror, Thomas J. Mildorf, Luciano Mueller
Publikováno v:
Cell, vol 152, iss 3
G-protein-coupled receptors (GPCRs) can modulate diverse signaling pathways, often in a ligand-specific manner. The full range of functionally relevant GPCR conformations is poorly understood. Here, we use NMR spectroscopy to characterize the conform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5575d1b4502aca2258749fcfe8939aa0
https://doi.org/10.1016/j.cell.2013.01.008
https://doi.org/10.1016/j.cell.2013.01.008
Autor:
Daniel Palmer, Cheng Zhang, Shaun R. Coughlin, Yoga Srinivasan, Anjali Pandey, Daniel H. Arlow, Ron O. Dror, Yaowu Zheng, David E. Shaw, Brian K. Kobilka, William I. Weis, Hillary F. Green, Juan Jose Fung
Publikováno v:
Nature. 492:387-392
Protease-activated receptor 1 (PAR1) is the prototypical member of a family of G-protein-coupled receptors that mediate cellular responses to thrombin and related proteases. Thrombin irreversibly activates PAR1 by cleaving the amino-terminal exodomai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef5554f8f97e7b451f06af06176c43ea
https://doi.org/10.1038/nature11701
https://doi.org/10.1038/nature11701
Autor:
Erica Rosemond, Pil Seok Chae, Hillary F. Green, William I. Weis, Jürgen Wess, Andrew C. Kruse, David E. Shaw, Daniel M. Rosenbaum, Ron O. Dror, Tong Liu, Daniel H. Arlow, Jianxin Hu, Brian K. Kobilka, Albert C. Pan
Publikováno v:
Nature
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77223405ac9cb6b269c2c7a705aa78d0
https://doi.org/10.1038/nature10867
https://doi.org/10.1038/nature10867
Autor:
Huafeng Xu, Thomas J. Mildorf, Daniel H. Arlow, Ron O. Dror, David E. Shaw, David W. Borhani, Paul Maragakis, Albert C. Pan
Publikováno v:
Proceedings of the National Academy of Sciences. 108:18684-18689
A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active and inactive functional states of GPCRs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c314b3198078386145d5de6e6e9fc310
https://doi.org/10.1073/pnas.1110499108
https://doi.org/10.1073/pnas.1110499108