Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Daniel Häußinger"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-6 (2023)
Abstract A monumental diversity of catalytic methods imparts the ability to select one of two configurations of tetravalent stereocentres. Conversely, catalyst control over pentavalent stereocentres, where a fifth moiety bound to the central atom enc
Externí odkaz:
https://doaj.org/article/a90c889dcfad45208c0d3f7831de771e
Autor:
Stefano Cucuzza, Malgorzata Sitnik, Simon Jurt, Erich Michel, Wenzhao Dai, Thomas Müntener, Patrick Ernst, Daniel Häussinger, Andreas Plückthun, Oliver Zerbe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Ultra-tight binding is usually observed for proteins associating with rigidified molecules. Previously, we demonstrated that femtomolar binders derived from the Armadillo repeat proteins (ArmRPs) can be designed to interact very tightly with
Externí odkaz:
https://doaj.org/article/6ecd578ebede4e9a9fc2b3220ddf5f61
Publikováno v:
JACS Au, Vol 2, Iss 7, Pp 1616-1626 (2022)
Externí odkaz:
https://doaj.org/article/2e0be2b05998456e9cd4f441d152cdb5
Autor:
Michela Consonni, Claudio Garavaglia, Andrea Grilli, Claudia de Lalla, Alessandra Mancino, Lucia Mori, Gennaro De Libero, Daniela Montagna, Monica Casucci, Marta Serafini, Chiara Bonini, Daniel Häussinger, Fabio Ciceri, Massimo Bernardi, Sara Mastaglio, Silvio Bicciato, Paolo Dellabona, Giulia Casorati
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Leukaemia therapy may benefit from the use of antigens that are less restricted to individual donors. Here the authors engineered T cells with a TCR specific for a CD1c restricted lipid leukaemia antigen and show that they can protect against disease
Externí odkaz:
https://doaj.org/article/a21e6ce293244d2e824f24fa9452ea8d
Publikováno v:
Frontiers in Chemistry, Vol 6 (2019)
Alkyl fluorides are generally regarded as chemically inert. However, several literature examples describe the activation of alkyl (sp3)C-F bonds via strong Brønsted or Lewis acids under harsh conditions. We here report that catalytic amounts of the
Externí odkaz:
https://doaj.org/article/d2deec9c80954e7db2ad8667f818643a
Autor:
Daniel Häussinger, Thomas Pfohl
Publikováno v:
CHIMIA, Vol 64, Iss 12 (2010)
Biophysical chemistry at the Department of Chemistry, University of Basel, covers the NMR analysis of protein–protein interaction using paramagnetic tags and sophisticated microscopy techniques investigating the dynamics of biological matter.
Externí odkaz:
https://doaj.org/article/3a78b4c1af4544acbb474982bf9bc527
Autor:
John B. Stiller, Renee Otten, Daniel Häussinger, Pascal S. Rieder, Douglas L. Theobald, Dorothee Kern
Publikováno v:
Nature
Macromolecular function frequently requires that proteins change conformation into high-energy states(1–4). However, methods for solving the structures of these functionally essential, lowly populated states are lacking. Here we develop a method fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37c8b99e2a5ffd55e0f89002f5d8b4a
https://doi.org/10.1038/s41586-022-04468-9
https://doi.org/10.1038/s41586-022-04468-9
Publikováno v:
Chemical Reviews. 122:9422-9467
Paramagnetic centers in biomolecules, such as specific metal ions that are bound to a protein, affect the nuclei in their surrounding in various ways. One of these effects is the pseudocontact shift (PCS), which leads to strong chemical shift perturb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38830a20b081ae9c531536b0e73b9cbc
https://doi.org/10.1021/acs.chemrev.1c00796
https://doi.org/10.1021/acs.chemrev.1c00796
Publikováno v:
Chem. 7:3144-3156
Summary Lanthanoid chelating tags (LCTs) are widely used for advanced paramagnetic NMR of biomacromolecules. The magnitude of their induced pseudocontact shifts (PCSs) and residual dipolar couplings (RDCs) depends critically on the anisotropy of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc93fa1823031a9ec1aa4773335ba5f
https://doi.org/10.1016/j.chempr.2021.08.011
https://doi.org/10.1016/j.chempr.2021.08.011
Autor:
Philip Rößler, Stephan Grzesiek, Layara Abiko, Feng-Jie Wu, Daniel Häussinger, Pascal Rieder, Alvar Gossert
Publikováno v:
Journal of the American Chemical Society, 144 (47)
NMR chemical shift changes can report on the functional dynamics of biomacromolecules in solution with sizes >1 MDa. However, their interpretation requires chemical shift assignments to individual nuclei, which for large molecules often can only be o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2fbaac12926fa0e9a91a05303c77a3
https://pubmed.ncbi.nlm.nih.gov/36394272
https://pubmed.ncbi.nlm.nih.gov/36394272