Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Daniel H, Doherty"'
Publikováno v:
The Protein Journal. 39:160-173
Previously we reported that site-specific modification of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) A3C analog with polyethylene glycol (PEG) dramatically improved the pharmacokinetic properties of the protein in rats. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b702e948f61c5439a879e090e1b2f888
https://doi.org/10.1007/s10930-020-09894-0
https://doi.org/10.1007/s10930-020-09894-0
Autor:
George N Cox, Elizabeth A Chlipala, Darin J Smith, Sharon J Carlson, Stacie J Bell, Daniel H Doherty
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91990 (2014)
Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino acid linker to an immunoglobulin-1 (IgG1)-Fc domain and that the G-CSF/IgG1-Fc fusion protein
Externí odkaz:
https://doaj.org/article/22e8833ab57e4fdb9941cddc793de4eb
Publikováno v:
Multifunctional Proteins: Catalytic/Structural and Regulatory ISBN: 9780429277009
The product of gene 32 has been shows to be involve in T4 Deoxyribonucleic acid (DNA) replication, molecular and genetic recombination, and the repair of ultraviolet light induced damage in T4 DNA. The protein might simply bind to and protect regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3773a4d500b86b30db7bb7adb31b6c74
https://doi.org/10.1201/9780429277009-4
https://doi.org/10.1201/9780429277009-4
Publikováno v:
BioProcess international. 3(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::921711fa19d73e7db742ff60b4c2f374
https://pubmed.ncbi.nlm.nih.gov/29899681
https://pubmed.ncbi.nlm.nih.gov/29899681
Autor:
Christine M. Fam, Ji I Lee, Mary S. Rosendahl, Daniel H. Doherty, George N. Cox, Stacie J. Bell, Elizabeth A. Chlipala, Sharon J. Carlson
Publikováno v:
Bioconjugate Chemistry. 19:299-305
Recombinant interferon alpha-2 (IFN-alpha2) has proven useful for treating a variety of human cancers and viral diseases. IFN-alpha2 has a short circulating half-life in vivo, which necessitates daily or thrice weekly administration to patients. It i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5934f660ce29217defa4f1a64fcc1a8d
https://doi.org/10.1021/bc070131q
https://doi.org/10.1021/bc070131q
Autor:
Elizabeth A. Chlipala, Sharon J. Carlson, Mary S. Rosendahl, Darin J. Smith, George N. Cox, Daniel H. Doherty
Publikováno v:
Endocrinology. 148:1590-1597
Recombinant human Growth Hormone (GH) is used to treat growth hormone deficiency in children and adults, and wasting in AIDS patients. GH has a circulating half-life of only a few hours in humans and must be administered to patients by daily injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c1d9f464d3a5d5f7940d07c353d894
https://doi.org/10.1210/en.2006-1170
https://doi.org/10.1210/en.2006-1170
Autor:
Elizabeth A. Chlipala, Kurt Christensen, Mary S. Rosendahl, Daniel H. Doherty, Dean P. Edwards, George N. Cox, Dana L. Long, Darin J. Smith, Stephen P. Eisenberg
Publikováno v:
Experimental Hematology. 34:697-704
Objective Erythropoietin (Epo) bioactivity is significantly reduced by modification of lysine residues with amine-reactive reagents, which are the most commonly used reagents for attaching polyethylene glycols (PEGs) to proteins to improve protein ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b274e3397eaaa9f4a3ac06ffaf51fc8e
https://doi.org/10.1016/j.exphem.2006.02.011
https://doi.org/10.1016/j.exphem.2006.02.011
Autor:
George N. Cox, Alison M. Bendele, Elizabeth A. Chlipala, Sharon J. Carlson, Daniel H. Doherty, Darin J. Smith
Publikováno v:
Experimental Hematology. 32:441-449
Objective The aim of this study was to determine whether fusion proteins comprising human granulocyte colony-stimulating factor (G-CSF) joined to human immunoglobulin G1 and G4 (IgG1 and IgG4) Fc and C H domains are biologically active and have impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389083bb982b2e558f5a84cfed5b0921
https://doi.org/10.1016/j.exphem.2004.01.012
https://doi.org/10.1016/j.exphem.2004.01.012
Autor:
Michael P. Doyle, John S. Olson, Douglas D. Lemon, Timothy J. Fattor, Daniel H. Doherty, Shawn R. Curry, Rita J. Vali
Publikováno v:
Nature Biotechnology. 16:672-676
Administration of extracellular hemoglobin-based oxygen carriers often induces mild increases in blood pressure. In order to test whether nitric oxide (NO) scavenging is responsible for the hypertensive effect, we constructed and tested a set of reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6ab61955e6b23fba341efe70b8266ef
https://doi.org/10.1038/nbt0798-672
https://doi.org/10.1038/nbt0798-672
Autor:
Elizabeth A. Chlipala, George N. Cox, Stacie J. Bell, Sharon J. Carlson, Daniel H. Doherty, Darin J. Smith
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91990 (2014)
PLoS ONE
PLoS ONE
Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino acid linker to an immunoglobulin-1 (IgG1)-Fc domain and that the G-CSF/IgG1-Fc fusion protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b08e6e1dd847082f2b495767d6c0333
http://europepmc.org/articles/PMC3956888?pdf=render
http://europepmc.org/articles/PMC3956888?pdf=render