Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Daniel Grubaugh"'
Autor:
Daniel C Akuma, Kimberly A Wodzanowski, Ronit Schwartz Wertman, Patrick M Exconde, Víctor R Vázquez Marrero, Chukwuma E Odunze, Daniel Grubaugh, Sunny Shin, Cornelius Taabazuing, Igor E Brodsky
Publikováno v:
eLife, Vol 13 (2024)
Inflammatory caspases are cysteine protease zymogens whose activation following infection or cellular damage occurs within supramolecular organizing centers (SMOCs) known as inflammasomes. Inflammasomes recruit caspases to undergo proximity-induced a
Externí odkaz:
https://doaj.org/article/9a7de7c6836d438db9bfd14207873e03
Autor:
Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A DeLaney, Opher S Kornfeld, Bettina L Lee, Eric M Rodríguez López, Daniel Grubaugh, Meghan A Wynosky-Dolfi, Naomi H Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P Beiting, Jorge Henao-Mejia, Brian C Schaefer, Kaiwen W Chen, Petr Broz, Igor E Brodsky
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Externí odkaz:
https://doaj.org/article/8d9976e5a9e54adc98393333ee0b5aa5
Autor:
Yoelys Cruz-Leal, Daniel Grubaugh, Catarina V. Nogueira, Isbel Lopetegui-González, Anaixis del Valle, Felipe Escalona, Rady J. Laborde, Carlos Alvarez, Luis E. Fernández, Michael N. Starnbach, Darren E. Higgins, María E. Lanio
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cross-presentation is an important mechanism for the differentiation of effector cytotoxic T lymphocytes (CTL) from naïve CD8+ T-cells, a key response for the clearance of intracellular pathogens and tumors. The liposomal co-encapsulation of the por
Externí odkaz:
https://doaj.org/article/5a034972a0854573bde313803249050a
Autor:
Joseph A. Perry, Lindsey Shallberg, Joseph T. Clark, Jodi A. Gullicksrud, Jonathan H. DeLong, Bonnie B. Douglas, Andrew P. Hart, Zachary Lanzar, Keenan O’Dea, Christoph Konradt, Jeongho Park, Juhi R. Kuchroo, Daniel Grubaugh, Arielle Glatman Zaretsky, Igor E. Brodsky, Rene de Waal Malefyt, David A. Christian, Arlene H. Sharpe, Christopher A. Hunter
Publikováno v:
Nature Immunology. 23:743-756
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1360105b00b4e769847c9bcbc34f3710
https://doi.org/10.1038/s41590-022-01170-w
https://doi.org/10.1038/s41590-022-01170-w
Autor:
Erin M. Harberts, Daniel Grubaugh, Daniel C. Akuma, Sunny Shin, Robert K. Ernst, Igor E. Brodsky
Publikováno v:
Infect Immun
Immune sensing of the Gram-negative bacterial membrane glycolipid lipopolysaccharide (LPS) is both a critical component of host defense against Gram-negative bacterial infection, and a contributor to hyper-inflammatory response, leading to sepsis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ccdc16221fb127dbc0bfd60accf37a
https://pubmed.ncbi.nlm.nih.gov/35862717
https://pubmed.ncbi.nlm.nih.gov/35862717
Autor:
Jasmine Alexander-Floyd, Antonia R. Bass, Erin M. Harberts, Daniel Grubaugh, Joseph D. Buxbaum, Igor E. Brodsky, Robert K. Ernst, Sunny Shin
Publikováno v:
Infect Immun
Detection of Gram-negative bacterial lipid A by the extracellular sensor, myeloid differentiation 2 (MD2)/Toll-like receptor 4 (TLR4), or the intracellular inflammasome sensors, CASP4 and CASP5, induces robust inflammatory responses. The chemical str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8e590929650556dc6d5998e749dc08
https://pubmed.ncbi.nlm.nih.gov/35862709
https://pubmed.ncbi.nlm.nih.gov/35862709
Autor:
Daniel C. Akuma, Daniel Grubaugh, Chukwuma E. Odunze, Sunny Shin, Cornelius Y. Taabazuing, Igor E. Brodsky
Inflammatory caspases are cysteine protease zymogens whose activation following infection or cellular damage occurs within supramolecular organizing centers (SMOCs) known as inflammsasomes. Inflammasomes are large oligomeric complexes that recruit ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dec551e9de65c5f95510e3b8797450d
https://doi.org/10.1101/2022.09.21.508824
https://doi.org/10.1101/2022.09.21.508824
Autor:
Catarina V. Nogueira, Rady J. Laborde, Yoelys Cruz-Leal, M. C. Luzardo, Darren E. Higgins, Lianne Abreu-Butin, Daniel Grubaugh, Audry Fernández, Ieda Maria Longo-Maugéri, Circe Mesa, Fabiola Pazos, María E. Lanio, Luis E. Fernández, Michael N. Starnbach, Mayari Eika Ishimura, Carlos Alvarez, María E. Alonso
Publikováno v:
Molecular Immunology. 131:144-154
Sticholysins (Sts) I and II (StI and StII) are pore-forming proteins (PFPs), purified from the Caribbean Sea anemone Stichodactyla helianthus. StII encapsulated into liposomes induces a robust antigen-specific cytotoxic CD8+ T lymphocytes (CTL) respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc6e326aff264a56b8da67d237bc4da
https://doi.org/10.1016/j.molimm.2020.12.032
https://doi.org/10.1016/j.molimm.2020.12.032
Autor:
Jasmine Alexander-Floyd, Antonia R. Bass, Erin M. Harberts, Daniel Grubaugh, Joseph D. Buxbaum, Igor E. Brodsky, Robert K. Ernst, Sunny Shin
Detection of Gram-negative bacterial lipid A by the extracellular sensor, MD-2/TLR4 or the intracellular inflammasome sensors, CASP4 and CASP5, induces robust inflammatory responses. The chemical structure of lipid A, specifically the phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6af5f98a62e5a95be2b44df7d68a63e
https://doi.org/10.1101/2021.12.16.472937
https://doi.org/10.1101/2021.12.16.472937
Autor:
Alexandra DeLaney, Opher S. Kornfeld, Bettina L. Lee, Daniel P. Beiting, Eric M. Rodriguez Lopez, Petr Broz, Timothée Fettrelet, Jorge Henao-Mejia, Daniel Grubaugh, Elisabet Bjanes, Benjamin Demarco, Reyna Garcia Sillas, Elise Krespan, Kaiwen W. Chen, Igor E. Brodsky, Meghan A. Wynosky-Dolfi, Dorothy Tovar, Rina Matsuda, Naomi H. Philip, Leonel Joannas, Brian C. Schaefer
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)
PLoS Pathogens
Plos Pathogens
PLoS pathogens, vol. 17, no. 10, pp. e1009967
PLoS Pathogens
Plos Pathogens
PLoS pathogens, vol. 17, no. 10, pp. e1009967
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d171193d88ea0f866dc6e57f786e24d
https://doaj.org/article/8d9976e5a9e54adc98393333ee0b5aa5
https://doaj.org/article/8d9976e5a9e54adc98393333ee0b5aa5