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Akademický článek

A Mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado–Joseph disease-like transgenic mice

Autor: Veronica F. Colomer Gould, Daniel Goti, Donna Pearce, Guillermo A. Gonzalez, Hong Gao, Mario Bermudez de Leon, Nancy A. Jenkins, Neal G. Copeland, Christopher A. Ross, Dale R. Brown

Publikováno v: Neurobiology of Disease, Vol 27, Iss 3, Pp 362-369 (2007)

Machado–Joseph disease also called spinocerebellar ataxia type 3 (MJD/SCA3) is a hereditary and neurodegenerative movement disorder caused by ataxin-3 with a polyglutamine expansion (mutant ataxin-3). Neuronal loss in MJD/SCA3 is associated with a

Externí odkaz: https://doaj.org/article/195a5ddb356a403a9dced3088e8de034

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A Mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado–Joseph disease-like transgenic mice

Autor: Dale R. Brown, Veronica F. Colomer Gould, Daniel Goti, Donna Pearce, Neal G. Copeland, Christopher A. Ross, Guillermo A. Gonzalez, Nancy A. Jenkins, Mario Bermúdez de León, Hong Gao

Publikováno v: Neurobiology of Disease, Vol 27, Iss 3, Pp 362-369 (2007)

Machado-Joseph disease also called spinocerebellar ataxia type 3 (MJD/SCA3) is a hereditary and neurodegenerative movement disorder caused by ataxin-3 with a polyglutamine expansion (mutant ataxin-3). Neuronal loss in MJD/SCA3 is associated with a mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058b15997af0f605b041c5d46f82e6c9
http://www.sciencedirect.com/science/article/pii/S0969996107001167

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37-kDa Laminin Receptor Precursor Modulates Cytotoxic Necrotizing Factor 1–mediated RhoA Activation and Bacterial Uptake

Autor: Suk Jin Hong, Sooan Shin, Ted M. Dawson, Monique F. Stins, Kee Jun Kim, Daniel Goti, Valina L. Dawson, Kwang Sik Kim, Jin Woong Chung

Publikováno v: Journal of Biological Chemistry. 278:16857-16862

Cytotoxic necrotizing factor 1 (CNF1) is a bacterial toxin known to activate Rho GTPases and induce host cell cytoskeleton rearrangements. The constitutive activation of Rho GTPases by CNF1 is shown to enhance bacterial uptake in epithelial cells and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab66698a767796bc6082cf08a6c3f23
https://doi.org/10.1074/jbc.m301028200

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Effects of Lipoprotein Lipase on Uptake and Transcytosis of Low Density Lipoprotein (LDL) and LDL-associated α-Tocopherol in a Porcine in Vitro Blood-Brain Barrier Model

Autor: Andelko Hrzenjak, Ernst Malle, Helga Reicher, Elke M. Wagner, Wolfgang Sattler, Ute Panzenboeck, Rudolf Zechner, Zoltan Balazs, Daniel Goti

Publikováno v: Journal of Biological Chemistry. 277:28537-28544

During the present study the contribution of lipoprotein lipase (LPL) to low density lipoprotein (LDL) holoparticle and LDL-lipid (alpha-tocopherol (alphaTocH)) turnover in primary porcine brain capillary endothelial cells (BCECs) was investigated. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0e78ddfd9c2c1089c145cb4fb08388
https://doi.org/10.1074/jbc.m203989200

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Uptake of Lipoprotein-Associated α-Tocopherol by Primary Porcine Brain Capillary Endothelial Cells

Autor: Hans-Joachim Galla, Astrid Hammer, Ernst Malle, Wolfgang Sattler, Daniel Goti

Publikováno v: Journal of Neurochemistry. 74:1374-1383

From the severe neurological syndromes resulting from vitamin E deficiency, it is evident that an adequate supply of the brain with alpha-tocopherol (alphaTocH), the biologically most active member of the vitamin E family, is of utmost importance. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304cb9c0d87be091fa6cb29c7d1bf320
https://doi.org/10.1046/j.1471-4159.2000.0741374.x

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Modulation of microglial superoxide production by α-tocopherol in vitro: attenuation of p67phox translocation by a protein phosphatase-dependent pathway

Autor: Wolfgang Sattler, Tamara Egger, Daniel Goti, Andrea Wintersperger, Astrid Hammer, Ernst Malle

Publikováno v: Journal of Neurochemistry. 79:1169-1182

As in other phagocytic cells, the NADPH-oxidase system in microglia is thought to be primarily responsible for the production of superoxide anion radicals (O2−·), a potentially cytotoxic reactive oxygen species. The assembly of a functional NADPH-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::929af0d0d065278f29b145b38cf3c14c
https://doi.org/10.1046/j.1471-4159.2001.00641.x

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Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E

Autor: Daniel Goti, Deneys R. van der Westhuyzen, Andelko Hrzenjak, Wolfgang Sattler, Sanja Levak-Frank, Saša Frank, Ernst Malle

Publikováno v: Journal of Neurochemistry. 76:498-508

It is clearly established that an efficient supply to the brain of alpha-tocopherol (alphaTocH), the most biologically active member of the vitamin E family, is of the utmost importance for proper neurological functioning. Although the mechanism of u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6daccd1ba75dabb3e8e1a379f7b5ff
https://doi.org/10.1046/j.1471-4159.2001.00100.x

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A neuroendocrine dysfunction, not testicular mutant ataxin-3 cleavage fragment or aggregate, causes cell death in testes of transgenic mice

Autor: V F Colomer Gould, Daniel Goti, J Kiluk

Publikováno v: Cell Death & Differentiation. 13:524-526

A neuroendocrine dysfunction, not testicular mutant ataxin-3 cleavage fragment or aggregate, causes cell death in testes of transgenic mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29df639678054ec03a12cc79ff2f9c2
https://doi.org/10.1038/sj.cdd.4401800

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High-density lipoprotein (HDL3)-associated alpha-tocopherol is taken up by HepG2 cells via the selective uptake pathway and resecreted with endogenously synthesized apo-lipoprotein B-rich lipoprotein particles

Autor: Daniel Goti, Ernst Malle, Gerhard M. Kostner, Wolfgang Sattler, Helga Reicher, Ute Panzenboeck

Publikováno v: The Biochemical journal. 332

alpha-Tocopherol (alphaTocH) is transported in association with lipoproteins in the aqueous milieu of the plasma. Although up to 50% of circulating alphaTocH is transported by high-density lipoproteins (HDLs), little is known about the mechanisms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd295c8e50dd1fe082b4cce66e8b5f83
https://pubmed.ncbi.nlm.nih.gov/9576851

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