Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Daniel Garcia-Santos"'
Publikováno v:
Haematologica, Vol 102, Iss 8 (2017)
Vertebrate heme synthesis requires three substrates: succinyl-CoA, which regenerates in the tricarboxylic acid cycle, iron and glycine. For each heme molecule synthesized, one atom of iron and eight molecules of glycine are needed. Inadequate deliver
Externí odkaz:
https://doaj.org/article/90d8420d81f04d06b022f462eedfc167
Autor:
Carine Fillebeen, Konstantinos Gkouvatsos, Gabriela Fragoso, Annie Calvé, Daniel Garcia-Santos, Marzell Buffler, Christiane Becker, Klaus Schümann, Prem Ponka, Manuela M. Santos, Kostas Pantopoulos
Publikováno v:
Haematologica, Vol 101, Iss 3 (2016)
Externí odkaz:
https://doaj.org/article/27266e6837eb42f0843cad7961335e41
Autor:
Carine Fillebeen, Konstantinos Gkouvatsos, Gabriela Fragoso, Annie Calvé, Daniel Garcia-Santos, Marzell Buffler, Christiane Becker, Klaus Schümann, Prem Ponka, Manuela M. Santos, Kostas Pantopoulos
Publikováno v:
Haematologica, Vol 100, Iss 9 (2015)
Externí odkaz:
https://doaj.org/article/0d90f44fdfc44da093db9c4443994e58
Autor:
Kostas Pantopoulos, John F. Presley, Hojatollah Vali, Daniel Garcia-Santos, Carine Fillebeen, Prem Ponka, Edouard Charlebois, John Wagner, Jeannie Mui, Angeliki Katsarou
Publikováno v:
Blood. 133:344-355
Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types. Its critical physiological function is highlighted by the embryonic lethal phenotype of Tfr1-knockout (Tfrc−/−
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48481c3b69b2e49b8a43360df09972e
https://doi.org/10.1182/blood-2018-05-850404
https://doi.org/10.1182/blood-2018-05-850404
Autor:
Prem Ponka, Zuzana Saxova, Monika Horvathova, Carine Fillebeen, Amel Hamdi, Kostas Pantopoulos, Daniel Garcia-Santos
Publikováno v:
Blood. 131:236-246
Thalassemias are a heterogeneous group of red blood cell disorders, considered a major cause of morbidity and mortality among genetic diseases. However, there is still no universally available cure for thalassemias. The underlying basis of thalassemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ebf64bd9f0d6a8f6d5b912b844bfe9
https://doi.org/10.1182/blood-2017-07-798728
https://doi.org/10.1182/blood-2017-07-798728
Publikováno v:
Trends in Biochemical Sciences. 42:395-406
Heme is a cofactor that is essential to almost all forms of life. The production of heme is a balancing act between the generation of the requisite levels of the end-product and protection of the cell and/or organism against any toxic substrates, int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb00d31760bb89f3f1815e9a34aa71c4
https://doi.org/10.1016/j.tibs.2017.01.006
https://doi.org/10.1016/j.tibs.2017.01.006
Autor:
Petra Pham, Tenzin Choesang, Jing Liu, Shuming Sun, Huihui Li, Jinghua Zhang, Weili Bao, Narla Mohandas, Maria Feola, Antonia Follenzi, Guiyuan Li, Prem Ponka, Robert E. Fleming, Huiyong Chen, Xiuli An, Yelena Ginzburg, Jie Li, Daniel Garcia-Santos, Stefano Rivella
Publikováno v:
Blood. 129:1514-1526
Iron availability for erythropoiesis and its dysregulation in β-thalassemia are incompletely understood. We previously demonstrated that exogenous apotransferrin leads to more effective erythropoiesis, decreasing erythroferrone (ERFE) and derepressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1bf7dfa110dfcabbc0f7fbf5998e10
https://doi.org/10.1182/blood-2016-09-742387
https://doi.org/10.1182/blood-2016-09-742387
Autor:
Prem Ponka, Abraham Bayer, Amel Hamdi, Sant-Rayn Pasricha, Jim R. Hughes, Alireza Morovat, Graça Porto, Tiago L. Duarte, Michael P. Murphy, Hal Drakesmith, Ana Gabriela Pires dos Santos, Jodie L. Babitt, Sarah Wideman, Elizabeth J. Soilleux, Pei Jin Lim, Hema Mehta, Andreia Santos-Gonçalves, Richard C. Hartley, Daniel Garcia-Santos, João Arezes, Paul Klenerman, Andrew E. Armitage, Christian B Willberg, Chia-Yu Wang
Publikováno v:
Nature Metabolism. 1(2019)
Iron is critical for life but toxic in excess because of iron-catalysed formation of pro-oxidants that cause tissue damage in a range of disorders. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) orchestrates cell-intrinsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9af55594d2d2fe580ff64c2ef27d98
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Medical Hypotheses. 74:807-813
Malaria affects thousands of people around the world representing a critical issue regarding health policies in tropical countries. Similarly, also haemolytic diseases such as sickle cell disease and thalassemias are a concern in different parts of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a399dbb7209646075dd37e1a0c691a0
https://doi.org/10.1016/j.mehy.2009.12.010
https://doi.org/10.1016/j.mehy.2009.12.010
Autor:
Renata Matuo, José Artur Bogo Chies, Fabrício Garmus Sousa, Alexandre E. Escargueil, Ivana Grivicich, João Antonio Pêgas Henriques, Annette K. Larsen, Daniel Garcia-Santos, Jenifer Saffi
Publikováno v:
Journal of Applied Toxicology. 29:308-316
5-Fluorouracil (5-FU) is an antineoplasic drug widely used to treat cancer. Its cytotoxic effect has been principally ascribed to the misincorporation of fluoronucleotides into DNA and RNA during their synthesis, and the inhibition of thymidylate syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0f0565c54e7907b2362c4d92716707
https://doi.org/10.1002/jat.1411
https://doi.org/10.1002/jat.1411