Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury

Autor: Daniel Garcia-Ovejero, Evelyn Beyerer, Orpheus Mach, Iris Leister, Martin Strowitzki, Christof Wutte, Doris Maier, John LK Kramer, Ludwig Aigner, Angel Arevalo-Martin, Lukas Grassner

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)

Abstract Background The discovery of new prognostic biomarkers following spinal cord injury (SCI) is a rapidly growing field that could help uncover the underlying pathological mechanisms of SCI and aid in the development of new therapies. To date, t

Externí odkaz: https://doaj.org/article/774e8d415fbb4a3a8581b08cc9251e7a

The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals

Autor: Alejandro Torrillas de la Cal, Beatriz Paniagua-Torija, Angel Arevalo-Martin, Christopher Guy Faulkes, Antonio Jesús Jiménez, Isidre Ferrer, Eduardo Molina-Holgado, Daniel Garcia-Ovejero

Publikováno v: Cells, Vol 10, Iss 9, p 2235 (2021)

In species that regenerate the injured spinal cord, the ependymal region is a source of new cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal region proliferate in normal conditions and react after injury, but in h

Externí odkaz: https://doaj.org/article/c0e58ef6a77b4434b17d86ffc2813cc5

The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury

Autor: Angel Arevalo-Martin, Daniel Garcia-Ovejero, Eduardo Molina-Holgado

Publikováno v: Neurobiology of Disease, Vol 38, Iss 2, Pp 304-312 (2010)

A series of pathological events secondary to spinal cord injury (SCI) contribute to the spread of the damage, which aggravates neurological deficits. Here we report that a single dose of the neuroprotective endocannabinoid 2-arachidonoyl glycerol (2-

Externí odkaz: https://doaj.org/article/fd1703c1cb55450ab00c5c2fb907f44f

Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery.

Autor: Angel Arevalo-Martin, Daniel Garcia-Ovejero, Yolanda Sierra-Palomares, Beatriz Paniagua-Torija, Ines Gonzalez-Gil, Silvia Ortega-Gutierrez, Eduardo Molina-Holgado

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49057 (2012)

Spinal cord injury (SCI) induces a cascade of processes that may further expand the damage (secondary injury) or, alternatively, may be part of a safeguard response. Here we show that after a moderate-severe contusive SCI in rats there is a significa

Externí odkaz: https://doaj.org/article/344bb135cc804e69a00299347a630684

A New Score Based on the International Standards for Neurological Classification of Spinal Cord Injury for Integrative Evaluation of Changes in Sensorimotor Functions

Autor: Lukas Grassner, Daniel Garcia-Ovejero, Orpheus Mach, Elisa Lopez-Dolado, Eduardo Vargas-Baquero, Monica Alcobendas-Maestro, Ana Esclarin, Ludwig Sanktjohaneser, Christof Wutte, Johannes Becker, Sara Lener, Sebastian Hartmann, Pierre-Pascal Girod, Nikolaus Kögl, Christoph J. Griessenauer, Marios Papadopoulus, Fred Geisler, Claudius Thome, Eduardo Molina-Holgado, Joan Vidal, Armin Curt, Giorgio Scivoletto, James Guest, Doris Maier, Norbert Weidner, Rüdiger Rupp, John L.K. Kramer, Angel Arevalo-Martin

Publikováno v: Journal of Neurotrauma
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Sensorimotor function of patients with spinal cord injury (SCI) is commonly assessed according to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI). From the ISNCSCI segmental motor and sensory assessments, u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23008b80a1af6c0c8239180a0ef0d321
https://doi.org/10.1089/neu.2021.0368