Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Daniel García-Rincón"'
1
Akademický článek
Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration
Autor: José Aguareles, Juan Paraíso-Luna, Belén Palomares, Raquel Bajo-Grañeras, Carmen Navarrete, Andrea Ruiz-Calvo, Daniel García-Rincón, Elena García-Taboada, Manuel Guzmán, Eduardo Muñoz, Ismael Galve-Roperh
Publikováno v: Translational Neurodegeneration, Vol 8, Iss 1, Pp 1-15 (2019)
Abstract Background The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated b
Externí odkaz: https://doaj.org/article/06f670319187485080ac1fedb5b6f158
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2
Akademický článek
An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.
Autor: Alberto Sanchez-Aguilera, Diek W Wheeler, Teresa Jurado-Parras, Manuel Valero, Miriam S Nokia, Elena Cid, Ivan Fernandez-Lamo, Nate Sutton, Daniel García-Rincón, Liset M de la Prida, Giorgio A Ascoli
Publikováno v: PLoS Biology, Vol 19, Iss 5, p e3001213 (2021)
Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping
Externí odkaz: https://doaj.org/article/76c57f9ca8144904bfda741260d3b031
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3
Akademický článek
Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia
Autor: Daniel García-Rincón, Javier Díaz-Alonso, Juan Paraíso-Luna, Zaira Ortega, José Aguareles, Adán de Salas-Quiroga, Cristina Jou, Inmaculada de Prada, Verónica Martínez-Cerdeño, Eleonora Aronica, Manuel Guzmán, María Ángeles Pérez-Jiménez, Ismael Galve-Roperh
Publikováno v: Frontiers in Pharmacology, Vol 9 (2019)
Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly and meg
Externí odkaz: https://doaj.org/article/2a143246417649ae9526920cece207f1
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4
Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors
Autor: Javier Díaz-Alonso, Juan Paraíso-Luna, Samuel Simón-Sánchez, Ane Cristina Ayo-Martin, Silvia Cappello, José Sánchez-Prieto, Daniel García-Rincón, Ricardo Martín, José Aguareles, Carlos Costas-Insua, Isabel Liste, Adán de Salas-Quiroga, Ismael Galve-Roperh, Elena García-Taboada, Manuel Guzmán
Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
The endocannabinoid (eCB) system, via the cannabinoid CB1 receptor, regulates neurodevelopment by controlling neural progenitor proliferation and neurogenesis. CB1 receptor signalling in vivo drives corticofugal deep layer projection neuron developme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c15d2a5d13dc3bab0063eddac413a64
https://doi.org/10.1242/dev.192161
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5
An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo
Autor: Manuel Valero, Miriam S. Nokia, Teresa Jurado-Parras, Nate Sutton, Alberto Sanchez-Aguilera, Elena Cid, Diek W. Wheeler, Giorgio A. Ascoli, Daniel García-Rincón, Liset Menendez de la Prida, Ivan Fernandez-Lamo
Publikováno v: PLoS Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Biology, Vol 19, Iss 5, p e3001213 (2021)
Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e818067675218b2db71f1cebe991ea0
https://pubmed.ncbi.nlm.nih.gov/33956790
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7
Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration
Autor: Elena García-Taboada, Eduardo Muñoz, Carmen Navarrete, Raquel Bajo-Grañeras, José Aguareles, Juan Paraíso-Luna, Andrea Ruiz-Calvo, Manuel Guzmán, Daniel García-Rincón, Belén Palomares, Ismael Galve-Roperh
Publikováno v: E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Translational Neurodegeneration, Vol 8, Iss 1, Pp 1-15 (2019)
E-Prints Complutense. Archivo Institucional de la UCM
instname
Translational Neurodegeneration
Background The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated by CB1 rec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d231bc25d18b279a56c73d79e04f2150
https://eprints.ucm.es/id/eprint/57136/1/Aguareles-DBBM-Oral-administration-of-the-cannabigerol.pdf
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8
Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB 1 receptors on developing cortical neurons
Autor: Adán de Salas-Quiroga, Manuel Guzmán, Floortje Remmers, Daniel García-Rincón, D. S. de Vega, Javier Díaz-Alonso, Beat Lutz, Ismael Galve-Roperh, María Gómez-Cañas
Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
The CB1 cannabinoid receptor, the main target of Δ(9)-tetrahydrocannabinol (THC), the most prominent psychoactive compound of marijuana, plays a crucial regulatory role in brain development as evidenced by the neurodevelopmental consequences of its
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0da3e5795cd1765eeddaca427168d4a
https://doi.org/10.1073/pnas.1514962112
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9
The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway
Autor: P Pruunsild, Luigi Bellocchio, Michael Sendtner, Cristina Blázquez, Eva Resel, Anna Chiarlone, Daniel García-Rincón, Beat Lutz, T Timmusk, Manuel Guzmán, Ismael Galve-Roperh
Publikováno v: Cell Death & Differentiation. 22:1618-1629
The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain. In particular, the CB1 receptor is highly expressed in the basal gangl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab973ced9986a723321e2ddd17b05dc1
https://doi.org/10.1038/cdd.2015.11
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10
Loss of Cannabinoid CB1Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility
Autor: Ismael Galve-Roperh, Javier Díaz-Alonso, Patricia P. Garcez, Daniel García-Rincón, Juan Paraíso-Luna, Manuel Guzmán, Clara Andradas, Adán de Salas-Quiroga, Cristina Sánchez, Maddy Parsons, François Guillemot
Publikováno v: Cerebral Cortex.
Neuronal migration is a fundamental process of brain development, and its disruption underlies devastating neurodevelopmental disorders. The transcriptional programs governing this process are relatively well characterized. However, how environmental
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4d947c2c57bd1e50bab05fea92ef36
https://doi.org/10.1093/cercor/bhw309
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