Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Daniel G. Morgan"'
Autor:
Michael R Weed, Joseph Polino, Laura Signor, Mark Bookbinder, Deborah Keavy, Yulia Benitex, Daniel G Morgan, Dalton King, John E Macor, Robert Zaczek, Richard Olson, Linda J Bristow
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0187609 (2017)
Agonists at the nicotinic acetylcholine alpha 7 receptor (nAChR α7) subtype have the potential to treat cognitive deficits in patients with Alzheimer's disease (AD) or schizophrenia. Visuo-spatial paired associates learning (vsPAL) is a task that ha
Externí odkaz:
https://doaj.org/article/7092e6186ae346de8340928c86171e4b
Autor:
Regina Miller, Nicholas J. Lodge, John E. Macor, Wendy Clarke, Lizbeth Gallagher, Linda J. Bristow, Daniel G. Morgan, Christiana I. Iwuagwu, Ryan Westphal, Haiquan Fang, Kimberley A. Lentz, Debra J. Post-Munson, Amy Easton, Matthew D. Hill, Bei Wang, Robert A. Mate, Ivar M. McDonald, James H. Cook, Yulia Benitex, Dalton King, Thaddeus F. Molski, Ronald J. Knox, F. Christopher Zusi, Richard E. Olson, Rex Denton, Jingsong Fan, Rulin Zhao, Robert Zaczek
Publikováno v:
ACS Medicinal Chemistry Letters. 8:366-371
The therapeutic treatment of negative symptoms and cognitive dysfunction associated with schizophrenia is a significant unmet medical need. Preclinical literature indicates that α7 neuronal nicotinic acetylcholine (nACh) receptor agonists may provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4993c640b254a344e08c8bc412ffe3
https://doi.org/10.1021/acsmedchemlett.7b00032
https://doi.org/10.1021/acsmedchemlett.7b00032
Autor:
Lizbeth Gallagher, Yulia Benitex, Matthew D. Hill, Richard E. Olson, Nicholas J. Lodge, Francine L. Healy, Debra J. Post-Munson, John E. Macor, Sivarao V. Digavalli, Daniel G. Morgan, JoAnne E Natale, Linda J. Bristow, Ping Chen, Haiquan Fang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:578-581
We describe the synthesis of quinuclidine-containing spiroguanidines and their utility as α7 neuronal nicotinic acetylcholine receptor (nAChR) partial agonists. The convergent synthetic route developed for this study allowed for rapid SAR investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8433cb3c9e99c00f072508da79af27
https://doi.org/10.1016/j.bmcl.2016.12.014
https://doi.org/10.1016/j.bmcl.2016.12.014
Autor:
Kelly Krause, Andrew P. Degnan, George O. Tora, Yu-Wen Li, Daniel G. Morgan, Ramkumar Rajamani, Joanna Hu, Ying Han, Rudolph G. Krause, Joanne J. Bronson, Robert L. Bertekap, Sarah J. Taylor, Kevin W. Gillman, Nicholas J. Lodge, Matthew T. Taber, John E. Macor, Gail K. Mattson, Melissa A. Cunningham, Carl D. Davis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3039-3043
Depression is a serious illness that affects millions of patients. Current treatments are associated with a number of undesirable side effects. Neurokinin 1 receptor (NK1R) antagonists have recently been shown to potentiate the antidepressant effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85bad869a118e4a255bfbb6b6ebb60f
https://doi.org/10.1016/j.bmcl.2015.04.098
https://doi.org/10.1016/j.bmcl.2015.04.098
Autor:
Yulia Benitex, Michael R. Weed, Laura J. Signor, Richard E. Olson, Deborah Keavy, Robert Zaczek, Linda J. Bristow, Daniel G. Morgan, Joseph Polino, Mark Bookbinder, Dalton King, John E. Macor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0187609 (2017)
PLoS ONE, Vol 12, Iss 12, p e0187609 (2017)
Agonists at the nicotinic acetylcholine alpha 7 receptor (nAChR α7) subtype have the potential to treat cognitive deficits in patients with Alzheimer's disease (AD) or schizophrenia. Visuo-spatial paired associates learning (vsPAL) is a task that ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585b43b4db7b4e1142684dfbf105df16
https://pubmed.ncbi.nlm.nih.gov/29261656
https://pubmed.ncbi.nlm.nih.gov/29261656
Autor:
Daniel G. Morgan, Colleen A. McNaney, Fu-ni Luan, Yulia Benitex, Eric Shields, Timothy V Olah, Dieter M. Drexler
Publikováno v:
Bioanalysis. 6:1901-1905
Background: (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, also known as LY379268, a group II metabotropic glutamate receptor agonist, has been widely used in neuroscience as a model compound in studies evaluating antipsychoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e30a133487c5139e10c778be6d02bb7
https://doi.org/10.4155/bio.14.103
https://doi.org/10.4155/bio.14.103
Autor:
Richard E. Olson, Ivar M. McDonald, Kimberly Newberry, Linda J. Bristow, Thaddeus F. Molski, Nicholas J. Lodge, Kelli M. Jones, Rick L. Pieschl, John E. Macor, Debra J. Post-Munson, Ryan Westphal, Ping Chen, Yu-Wen Li, Amy Easton, Yulia Benitex, Robert Zaczek, Yukiko Asaka, James Herrington, Siva Digavalli, Regina Miller, Daniel G. Morgan
Publikováno v:
European journal of pharmacology. 807
The α7 nicotinic acetylcholine receptor is thought to play an important role in human cognition. Here we describe the in vivo effects of BMS-902483, a selective potent α7 nicotinic acetylcholine receptor partial agonist, in relationship to α7 nico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f575d42b7bec741272adfcfbfcd33b57
https://pubmed.ncbi.nlm.nih.gov/28438647
https://pubmed.ncbi.nlm.nih.gov/28438647
Autor:
Regina Miller, Michele Matchett, Nicholas J. Lodge, Yulia Benitex, Thaddeus F. Molski, Wendy Clarke, John E. Macor, Rulin Zhao, Robert Zaczek, Linda J. Bristow, Amy Easton, Christiana I. Iwuagwu, JoAnne E Natale, Haiquan Fang, Ronald J. Knox, Baoqing Ma, F. Christopher Zusi, Siva Digavalli, James H. Cook, Matthew D. Hill, Francine L. Healy, Debra J. Post-Munson, Jingfang Qian Cutrone, Daniel G. Morgan, Bei Wang, Richard E. Olson, Qi Gao, Rex Denton, Robert A. Mate, Ivar M. McDonald, Dalton King, Meredith Ferrante, Kimberley A. Lentz, Kelli M. Jones, Judith A. Siuciak, Lizbeth Gallagher
Publikováno v:
Journal of medicinal chemistry. 59(24)
The design and synthesis of a series of quinuclidine-containing spirooxazolidines (“spiroimidates”) and their utility as α7 nicotinic acetylcholine receptor partial agonists are described. Selected members of the series demonstrated excellent se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7168f463fa8dafe0bc3dd8512c11678
https://pubmed.ncbi.nlm.nih.gov/27958732
https://pubmed.ncbi.nlm.nih.gov/27958732
Autor:
Daniel G. Morgan, Wendy Clarke, Nicholas J. Lodge, Yulia Benitex, John E. Macor, Debra J. Post-Munson, Ivar M. McDonald, Richard E. Olson, Dalton King, Rex Denton, Amy Easton, Ronald J. Knox, Kimberley A. Lentz, Christiana I. Iwuagwu, Matthew D. Hill, F. Christopher Zusi, Haiquan Fang, Robert Zaczek, Linda J. Bristow, Robert A. Mate, James H. Cook, Regina Miller
We describe the synthesis of quinuclidine-containing spiroimidates and their utility as α7 nicotinic acetylcholine receptor (nAChR) partial agonists. A convergent synthetic route allowed for rapid SAR investigation and provided a diverse set of fuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c72cac8d11dcb33041f5390751e60f
https://europepmc.org/articles/PMC5238485/
https://europepmc.org/articles/PMC5238485/
Autor:
Colleen A. McNaney, Dieter M. Drexler, David Luchetti, Timothy V Olah, Daniel G. Morgan, Yulia Benitex, Eric Schaeffer
Publikováno v:
Rapid Communications in Mass Spectrometry. 27:1882-1886
RATIONALE: Research on disorders of the central nervous system (CNS) has shown that an imbalance in the levels of specific endogenous neurotransmitters may underlie certain CNS diseases. These alterations in neurotransmitter levels may provide insigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f03b198e273093a2eaad997e6f6470e
https://doi.org/10.1002/rcm.6639
https://doi.org/10.1002/rcm.6639