Výsledky vyhledávání - "Daniel G. Genov"

A Design of Experiments Approach to a Robust Final Deprotection and Reactive Crystallization of IPI-926, A Novel Hedgehog Pathway Inhibitor

Autor: Martin Trudeau, Louis Grenier, Kristopher M. Depew, Daniel G. Genov, Alexandre Côté, Brian C. Austad, Lin-Chen Yu, Andre Lescarbeau, Theodore A. Martinot, Priscilla L. White, Joseph Helble, Somarajan J. Nair

Publikováno v: Organic Process Research & Development. 19:1693-1702

A design of experiments (DoE) approach was taken to optimize purity and reaction yield of the final debenzylation and hydrochloride salt formation of IPI-926. The study involved a careful dissection of the different process steps to enable an indepen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::303b6bb1bcb0f53d2408fcb4957573f0
https://doi.org/10.1021/acs.oprd.5b00214

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A NEW EFFICIENT PROTOCOL FOR THE PREPARATION OF CHIRAL BISPHOSPHINES OF THE BICP FAMILY

Autor: Daniel G. Genov

Publikováno v: Phosphorus, Sulfur, and Silicon and the Related Elements. 179:1949-1958

A new procedure for the synthesis of chiral BICP ligands is described. The protocol involves the reaction of sodium diarylphosphide–borane complex with chiral 2,2′-bisbenzenesulfonyl-1,1′-dicyclopentane in toluene, followed by HBF4·OMe2-mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77b49315032a98b4ab48b3cff280c3dc
https://doi.org/10.1080/10426500490466977

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Synthesis of New Bicyclic P−N Ligands and Their Application in Asymmetric Pd-Catalyzed π-Allyl Alkylation and Heck Reaction

Autor: Daniel G. Genov, Arnold L. Rheingold, Scott R. Gilbertson

Publikováno v: Organic Letters. 2:2885-2888

[structure: see text] The synthesis of phosphine oxazoline ligands based on P-chiral 1-phosphanorbornadienes is reported. The use of these ligands in palladium catalyzed asymmetric allylation and Heck reaction is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bdd1ff674ddea8a3334db8a299236b
https://doi.org/10.1021/ol006323h

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CONFORMATIONAL ANALYSIS OF 2-SUBSTITUTED ALKYLPHOSPHORYL COMPOUNDS. PART 2. 1H NMR, IR AND MOLECULAR MECHANICS MODELLING STUDIES OF THE SOLVATION OF 2-HYDROXYPENTYLPHOSPHONATES

Autor: John C. Tebby, Daniel G. Genov

Publikováno v: Phosphorus, Sulfur, and Silicon and the Related Elements. 114:91-98

IR, molecular weight and molecular mechanics modelling studies of 2-hydroxypentylphosphonates indicate that intramolecular hydrogen bonding has a significant influence on the position of the confor...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58b4788fdcb229445fab4014b099225f
https://doi.org/10.1080/10426509608046414

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Conformational Analysis of (2-Substituted-alkyl)phosphoryl Compounds. 1. NMR Spectroscopic Studies of Dialkyl (2-Hydroxyalkyl)phosphonates and Their Carboxylic Esters

Autor: Daniel G. Genov, John C. Tebby

Publikováno v: The Journal of Organic Chemistry. 61:2454-2459

Twelve (2-substituted-alkyl)phosphonates (2, 3) were synthesized and conformational analyses carried out by NMR spectroscopy. The conformational populations in six solvents with different polarities and in the presence of metal ions (Li+, Na+, Zn2+),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c71dc9c0d8fc937b386b4f73b519ea52
https://doi.org/10.1021/jo950364n

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