Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Daniel G. Fraser"'
Autor:
Jennifer L. Rowsey, Joshua N. Farr, Daniel G. Fraser, Sundeep Khosla, Brittany A. Eckhardt, Ruben Aquino-Martinez, David G. Monroe
Publikováno v:
J Periodontol
Background Coinciding with other chronic comorbidities, the prevalence of periodontal disease increases with aging. Mounting evidence has established that senescent cells accumulate at sites of age-related pathologies, where they promote "non-microbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69119a6ff110451bd46c5ceb6edea4ae
https://doi.org/10.1002/jper.20-0529
https://doi.org/10.1002/jper.20-0529
Autor:
Brittany A. Eckhardt, Tamar Tchkonia, Jennifer L. Rowsey, Daniel G. Fraser, David G. Monroe, Joshua N. Farr, James L. Kirkland, Brianne S Thicke, Sundeep Khosla
Publikováno v:
J Bone Miner Res
Estrogen deficiency is a seminal mechanism in the pathogenesis of osteoporosis. Mounting evidence, however, establishes that cellular senescence, a fundamental mechanism that drives multiple age-related diseases, also causes osteoporosis. Recently, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2652d7d3d33f8359d1d3fe99521780
https://doi.org/10.1002/jbmr.3729
https://doi.org/10.1002/jbmr.3729
Autor:
Sundeep Khosla, Ruben Aquino-Martinez, Brittany A. Eckhardt, David G. Monroe, Daniel G. Fraser, Joshua N. Farr, Jennifer L. Rowsey
Publikováno v:
Bone
Cellular senescence is associated with inflammation and extracellular matrix tissue remodeling through the secretion of proteins termed the senescence-associated secretory phenotype (SASP). Although osteocyte senescence in older individuals in the sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d29e3645ee6ba4f67c626ae04ab3b2
https://europepmc.org/articles/PMC6990876/
https://europepmc.org/articles/PMC6990876/
Autor:
Brittany A Negley, McKenzie M Fulcer, Jennifer L Onken, David G. Monroe, Daniel G. Fraser, Joshua N. Farr, Brianne S Thicke, Andre J. Van Wijnen, Megan M. Weivoda, Ruben Aquino-Martinez, Sundeep Khosla
Publikováno v:
Journal of Bone and Mineral Research. 34:135-144
Developing novel approaches to treat skeletal disorders requires an understanding of how critical molecular factors regulate osteoblast differentiation and bone remodeling. We have reported that (1) retinoic acid receptor-related orphan receptor beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c9332b10e22cbe5d2f1a09ad392b04
https://doi.org/10.1002/jbmr.3586
https://doi.org/10.1002/jbmr.3586
Autor:
Ming Ruan, Joshua N. Farr, Douglas Forrest, Brianne S Thicke, Megan M. Weivoda, Hong Liu, Kristy M. Nicks, John R. Hawse, Jennifer L Onken, Daniel G. Fraser, Sundeep Khosla, David G. Monroe, Brittany A Negley
Publikováno v:
Journal of Bone and Mineral Research. 33:720-731
There is a clinical need to identify new molecular targets for the treatment of osteoporosis, particularly those that simultaneously inhibit bone resorption while stimulating bone formation. We have previously shown in overexpression studies that ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8419fd767db37b8aa47fc82d9a0a5d
https://doi.org/10.1002/jbmr.3351
https://doi.org/10.1002/jbmr.3351
Autor:
Sundeep Khosla, Ming Xu, Merry Jo Oursler, David G. Monroe, Tamara Tchkonia, Brittany A Negley, Megan M. Weivoda, Tamar Pirtskhalava, Joshua N. Farr, Daniel G. Fraser, Mikolaj Ogrodnik, Christine M Hachfeld, Robert J. Pignolo, Matthew T. Drake, Jennifer L Onken, Nathan K. LeBrasseur, James L. Kirkland, Jad G Sfeir
Publikováno v:
Nature medicine
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple co-morbidities1. Here, we investigate a role for senescent cells in age-related bone loss by multiple approaches. In particula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063e8b3eb86010ac777721890e2feba3
https://doi.org/10.1038/nm.4385
https://doi.org/10.1038/nm.4385
Autor:
Katherine L O'Grady, Brianne S Thicke, João F. Passos, Jennifer L. Rowsey, Olga P. Bondar, Aleksey V. Matveyenko, Brittany A. Eckhardt, David G. Monroe, Anthony B. Lagnado, Ravinder J. Singh, Sundeep Khosla, Daniel G. Fraser, Adrian Vella, Jolaine M. Hines, Joshua N. Farr, Andrew R. Thoreson, Kuntol Rakshit
Publikováno v:
JCI Insight
The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part, from poor bone quality. Advanced glycation endproducts (AGEs) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50ab98e6bb0ee524200ad12628652ac
https://pubmed.ncbi.nlm.nih.gov/32267250
https://pubmed.ncbi.nlm.nih.gov/32267250
Autor:
Tamara Tchkonia, Sundeep Khosla, Daniel G. Fraser, Mikolaj Ogrodnik, Nathan K. LeBrasseur, Lynda F. Bonewald, David G. Monroe, Matthew T. Drake, Katharina Jaehn, James L. Kirkland, Haitao Wang, Megan M. Weivoda, Joshua N. Farr, Robert J. Pignolo
Publikováno v:
Journal of Bone and Mineral Research. 31:1920-1929
Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic alterations, including upregulation of p16Ink4a , profound secretome changes, telomere shortening, and decond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94c45e32f05805fc3325ac9e465f47d6
https://doi.org/10.1002/jbmr.2892
https://doi.org/10.1002/jbmr.2892
Autor:
Kristy M. Nicks, Meghan E. McGee-Lawrence, Jennifer J. Westendorf, David G. Monroe, Koji Fujita, Daniel G. Fraser, Ulrike McGregor, Matthew T. Drake, Sundeep Khosla
Publikováno v:
Journal of Bone and Mineral Research. 31:606-614
Although the role of ERα in regulating bone metabolism has been extensively studied, ERβ has been largely dismissed as a relevant modulator of bone mass. Previous studies examining ERβ utilized a germline knockout mouse expressing transcript varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d66f34c60d92b93342c12e35604a82c5
https://doi.org/10.1002/jbmr.2723
https://doi.org/10.1002/jbmr.2723
Autor:
Bettina M. Weigand, Christine M Hachfeld, Ming Xu, Joshua N. Farr, Xiaonan Hou, Vesna D. Garovic, Jennifer L Onken, Larissa G.P. Langhi, Tamar Pirtskhalava, Hajrunisa Cubro, Ravinder J. Singh, S. John Weroha, Megan M. Weivoda, Mikolaj Ogrodnik, Kurt O. Johnson, Keisuke Ejima, Gene B. Hubbard, Laura J. Niedernhofer, Grace C Verzosa, Diana Jurk, James L. Kirkland, Paul D. Robbins, Moritz Weigl, Christina L. Inman, Jordan D. Miller, Daniel G. Fraser, David B. Allison, Nino Giorgadze, Sundeep Khosla, Yuji Ikeno, Allyson K. Palmer, Tamara Tchkonia, Nathan K. LeBrasseur
Publikováno v:
Nature medicine
Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02db7172651264fd5240a5fe961df9ae
https://pubmed.ncbi.nlm.nih.gov/30292430
https://pubmed.ncbi.nlm.nih.gov/30292430