Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Daniel G W, Alanine"'
Autor:
Barnabas G. Williams, Lloyd D. W. King, David Pulido, Doris Quinkert, Amelia M. Lias, Sarah E. Silk, Robert J. Ragotte, Hannah Davies, Jordan R. Barrett, Kirsty McHugh, Cassandra A. Rigby, Daniel G. W. Alanine, Lea Barfod, Michael W. Shea, Li An Cowley, Rebecca A. Dabbs, David J. Pattinson, Alexander D. Douglas, Oliver R. Lyth, Joseph J. Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M. Christen, Amy R. Noe, Randall S. MacGill, C. Richter King, Ashley J. Birkett, Lorraine A. Soisson, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeri
Externí odkaz:
https://doaj.org/article/c0357f954cd04ff984155d03439a386e
Autor:
Robert J. Ragotte, David Pulido, Amelia M. Lias, Doris Quinkert, Daniel G. W. Alanine, Abhishek Jamwal, Hannah Davies, Adéla Nacer, Edward D. Lowe, Geoffrey W. Grime, Joseph J. Illingworth, Robert F. Donat, Elspeth F. Garman, Paul W. Bowyer, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Antibodies can have synergistic effects, but mechanisms are not well understood. Here, Ragotte et al. identify three antibodies that bind neighbouring epitopes on CyRPA, a malaria vaccine candidate, and show that lateral interactions between the anti
Externí odkaz:
https://doaj.org/article/311198660694450bbebda7b48bd4d1b2
Autor:
Alexander D. Douglas, G. Christian Baldeviano, Jing Jin, Kazutoyo Miura, Ababacar Diouf, Zenon A. Zenonos, Julio A. Ventocilla, Sarah E. Silk, Jennifer M. Marshall, Daniel G. W. Alanine, Chuan Wang, Nick J. Edwards, Karina P. Leiva, Luis A. Gomez-Puerta, Carmen M. Lucas, Gavin J. Wright, Carole A. Long, Joseph M. Royal, Simon J. Draper
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Proof of protection against blood-stage P. falciparum malaria by a single immunological mechanism has been elusive. Here, using engineered anti-PfRH5 chimeric monoclonal antibodies in non-human primates, the authors show that high levels of merozoite
Externí odkaz:
https://doaj.org/article/3b9dfa5270d844208baf55b37a0ad4bc
Autor:
Eman Ali Ali, Marina Kalli, Daniel Wan, Ryosuke Nakamura, David Onion, Daniel G W Alanine, Marcos J C Alcocer, Franco H Falcone
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221034 (2019)
Several laboratories have created rat basophil leukemia (RBL) cell lines stably transfected with the human high affinity IgE receptor (FcεRIH). More recently, humanized RBL cell lines saw the introduction of reporter genes such as luciferase (RS-ATL
Externí odkaz:
https://doaj.org/article/586da42ea64b480ab6df1dd86c2d6a4f
Autor:
Lander Foquet, Carola Schafer, Nana K. Minkah, Daniel G. W. Alanine, Erika L. Flannery, Ryan W. J. Steel, Brandon K. Sack, Nelly Camargo, Matthew Fishbaugher, Will Betz, Thao Nguyen, Zachary P. Billman, Elizabeth M. Wilson, John Bial, Sean C. Murphy, Simon J. Draper, Sebastian A. Mikolajczak, Stefan H. I. Kappe
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The invention of liver-humanized mouse models has made it possible to directly study the preerythrocytic stages of Plasmodium falciparum. In contrast, the current models to directly study blood stage infection in vivo are extremely limited. Humanizat
Externí odkaz:
https://doaj.org/article/c64469f54c4448cfa0dcb7e11dccc724
Autor:
Daria Nikolaeva, Sumi Biswas, Iona J. Brian, Daniel G. W. Alanine, Kazutoyo Miura, Simon J. Draper, Carole A. Long, Alex Fyfe, Yuanyuan Li, Dari F. Da, Anna Cohuet, Joseph J. Illingworth
Publikováno v:
Molecular & Cellular Proteomics : MCP
The malaria agent Plasmodium falciparum continues to evade control efforts. Despite multiple datasets for the Plasmodium sexual-stage transcriptome and proteome, there have been no rational screens to identify candidate antigens for transmission-bloc
Autor:
Robert J, Ragotte, David, Pulido, Amelia M, Lias, Doris, Quinkert, Daniel G W, Alanine, Abhishek, Jamwal, Hannah, Davies, Adéla, Nacer, Edward D, Lowe, Geoffrey W, Grime, Joseph J, Illingworth, Robert F, Donat, Elspeth F, Garman, Paul W, Bowyer, Matthew K, Higgins, Simon J, Draper
Publikováno v:
Nature communications. 13(1)
Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. Examples of synergy between antibodies are well-documented, but the mechanisms underlying these relationships often remain poorly understo
Autor:
Kazutoyo Miura, David Pulido, Alex S. Huber, Simon J. Draper, Alexandra C. Willcox, Angela M. Minassian, Mahamadou Diakite, Lloyd D.W. King, Daniel G. W. Alanine, Jordan R. Barrett, Carole A. Long, Ababacar Diouf, Sarah E. Silk
Publikováno v:
Cell Reports Medicine
Summary Reticulocyte-binding protein homolog 5 (RH5) is a leading Plasmodium falciparum blood-stage vaccine candidate. Another possible candidate, apical membrane antigen 1 (AMA1), was not efficacious in malaria-endemic populations, likely due to pre
Autor:
Robert W. Moon, Geneviève M. Labbé, Franziska Mohring, Simon J. Draper, Sarah E. Silk, Jee Sun Cho, Natalie M. Barber, Doris Quinkert, François Nosten, Bruce Russell, Thomas A. Rawlinson, Jennifer M. Marshall, Samuel F. Gérard, Varakorn Kosaisavee, Laurent Rénia, Ruth O. Payne, Angela M. Minassian, Jing Jin, Daniel G. W. Alanine, Sean C. Elias, Matthew K. Higgins
Publikováno v:
Nature microbiology
Nature Microbiology
Nature Microbiology
Summary The most widespread form of malaria is caused by Plasmodium vivax. To replicate, this parasite must invade immature red blood cells, through a process which requires interaction of the Plasmodium vivax Duffy binding protein, PvDBP with its hu
Autor:
Daniel Wan, Fernanda Ludolf, Daniel G W Alanine, Owen Stretton, Eman Ali Ali, Nafal Al-Barwary, Xiaowei Wang, Michael J Doenhoff, Adriano Mari, Colin M Fitzsimmons, David W Dunne, Ryosuke Nakamura, Guilherme C Oliveira, Marcos J C Alcocer, Franco H Falcone
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3124 (2014)
Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of the IgE response in S. mansoni infection have been characterised. A better insight into the basic mec
Externí odkaz:
https://doaj.org/article/6f1a2532c35a4c3c967e91d826f512e9