Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Daniel G Hurley"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80171 (2013)
BackgroundThe nucleic acid-binding protein YB-1, a member of the cold-shock domain protein family, has been implicated in the progression of breast cancer and is associated with poor patient survival. YB-1 has sequence similarity to LIN28, another co
Externí odkaz:
https://doaj.org/article/dedcf6812fea48ee9e8f342ffb35d28b
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72103 (2013)
We develop a new regression algorithm, cMIKANA, for inference of gene regulatory networks from combinations of steady-state and time-series gene expression data. Using simulated gene expression datasets to assess the accuracy of reconstructing gene r
Externí odkaz:
https://doaj.org/article/2907d24ed5544cb89a0ed9c33f33956e
Autor:
Li Wang, Daniel G Hurley, Wendy Watkins, Hiromitsu Araki, Yoshinori Tamada, Anita Muthukaruppan, Louis Ranjard, Eliane Derkac, Seiya Imoto, Satoru Miyano, Edmund J Crampin, Cristin G Print
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34247 (2012)
BackgroundOur understanding of the molecular pathways that underlie melanoma remains incomplete. Although several published microarray studies of clinical melanomas have provided valuable information, we found only limited concordance between these s
Externí odkaz:
https://doaj.org/article/569980040a424319b199786c83cca5d8
Autor:
Daniel G. Hurley, Jonathan Cebon, Joseph Cursons, Andreas Behren, Matthew Anaka, Miles C. Andrews, Edmund J. Crampin
Publikováno v:
Molecular Cancer
Background In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processes such as epithelial-mesenchymal plasticity. This can be driven by miRs targeting multiple mRNA transcripts, inducing reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb94476aa043e046d2932dea649e522
Autor:
Maria Rondon-Galeano, Cathy Pichol-Thievend, Benjamin W. Lindsey, Naoki Mochizuki, Jan Kaslin, Stephen J. Bent, Sungmin Baek, Cas Simons, Isaac Virshup, Neil I. Bower, Mathias Francois, Daniel G. Hurley, Christine A. Wells, Benjamin M. Hogan, Weili Wang, Katarzyna Koltowska, Anne K. Lagendijk, Scott Paterson
Publikováno v:
Nature Neuroscience. 20:774-783
Mural cells of the vertebrate brain maintain vascular integrity and function, play roles in stroke and are involved in maintenance of neural stem cells. However, the origins, diversity and roles of mural cells remain to be fully understood. Using tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a166c10ed68b10470be86a03448ebc9
https://doi.org/10.1038/nn.4558
https://doi.org/10.1038/nn.4558
Autor:
Annette Lasham, Cristin G. Print, Adele G. Woolley, Andrew N. Shelling, James I. Hearn, Sandra Fitzgerald, Michael Algie, Daniel G. Hurley, Sunali Mehta, Igor Ruza, Antony W. Braithwaite
Publikováno v:
International Journal of Cancer. 139:1157-1170
Chemotherapy with taxanes such as paclitaxel (PTX) is a key component of triple negative breast cancer (TNBC) treatment. PTX is used in combination with other drugs in both the adjuvant setting and in advanced breast cancer. Because a proportion of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98799239b43fc8f44028d5e66ea6f30f
https://doi.org/10.1002/ijc.30137
https://doi.org/10.1002/ijc.30137
Autor:
Kirankumar S. Mysore, Geoffrey Thomson, Jiangqi Wen, Mauren Jaudal, Lulu Zhang, Chong Che, Daniel G. Hurley, Joanna Putterill
Publikováno v:
The Plant Journal. 86:145-160
Optimising the timing of flowering contributes to successful sexual reproduction and yield in agricultural plants. FLOWERING LOCUS T (FT) genes, first identified in Arabidopsis thaliana (Arabidopsis), promote flowering universally, but the upstream f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ec00a369cffd7fff95806ee9ff1301a
https://doi.org/10.1111/tpj.13156
https://doi.org/10.1111/tpj.13156
Autor:
Daniel G. Hurley, Teena Gamage, Peter Tsai, Joanna L. James, Lawrence W. Chamley, Chandrakanth Bhoothpur, Robert J. Weeks, Jackie L. Ludgate, William Schierding, Erin C. Macaulay
Publikováno v:
Epigenetics. 13(12)
The placenta is a vital fetal exchange organ connecting mother and baby. Specialised placental epithelial cells, called trophoblasts, are essential for adequate placental function. Trophoblasts transform the maternal vasculature to allow efficient bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584741f8a86fa42452bbb23ec6583771
https://pubmed.ncbi.nlm.nih.gov/30475094
https://pubmed.ncbi.nlm.nih.gov/30475094
Isolation and characterisation of a novel trophoblast side-population from first trimester placentae
Autor:
Lawrence W. Chamley, Teena Gamage, Joanna L. James, Tony Zhang, Daniel G. Hurley, Padma Murthi, Priya Pantham, Ryash Vather
Publikováno v:
Europe PubMed Central
The placenta is responsible for all nutrient and gas exchange between mother and baby during pregnancy. The differentiation of specialised placental epithelial cells called trophoblasts is essential for placental function, but we understand little ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d5e2197d47f86b32fb7a79720d26a1
https://doi.org/10.1530/rep-14-0646
https://doi.org/10.1530/rep-14-0646
Autor:
Cristin G. Print, William R. Wilson, H. D. Sarath Liyanage, Daniel G. Hurley, Yongchuan Gu, Francis W. Hunter, Sarah P. McManaway, Moana Tercel, Jagdish K. Jaiswal, Frederik B. Pruijn, Jingli Wang, Susan Richter
Publikováno v:
Biochemical Pharmacology. 89:224-235
The nitro-chloromethylbenzindoline prodrug SN29428 has been rationally designed to target tumour hypoxia. SN29428 is metabolised to a DNA minor groove alkylator via oxygen-sensitive reductive activation initiated by unknown one-electron reductases. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0734d007abf7a4d4e26e2dddcb5e4525
https://doi.org/10.1016/j.bcp.2014.03.001
https://doi.org/10.1016/j.bcp.2014.03.001